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Spanish Experience with Latero-Lateral Duodeno-Ileostomy + Sleeve Gastrectomy with Magnet Anastomosis System
Abstract
Background The partial diversion of intestinal contents facilitates achieving and maintaining weight loss and improving glycemic control in patients with obesity and with or without T2DM. The purpose of this study is to report our experience and 1-year follow-up with novel modification of SADI-S. Methods This study is a part of a multicentric trial of patients that underwent primary side-to-side duodeno-ileostomy and sleeve gastrectomy (SG) with GT metabolic solutions magnetic anastomosis system. Feasibility, safety, and initial efficacy were evaluated. Results The mean age of the patients included was 48 ± 8.75 years and the preoperative BMI was 43.32 ± 2.82 kg/m 2. The complications were present in 30% of patients. The anastomosis patency was confirmed by the passage of radiological contrast under fluoroscopy at a mean of 17 days (17-29 days), and the mean expulsion time was 42 days (32-62). The mean diameter of the anastomosis after the magnet expulsion was 13.8 × 11.4 mm. The percentage of total weight lost at 1 year was 38.68 ± 8.48% (p < 0.001). The percentage of excess weight loss 82.5 ± 18.44% (p < 0.001) and improvements in glucose profiles were observed. Mean baseline HbA1c 5.77 ± 0.31% was reduced to 5.31 ± 0.26% (p < 0.024). Conclusions Latero-lateral duodeno-ileostomy + SG with magnetic duodenal bipartition is afeasible and reasonably safe technique and induces weight loss in patients with obesity and improvement of glycemic control. This modification could be considered as an option to standard SADI-S or as a first step in two stages procedure. However, larger studies are needed. Trial registration Clinicaltrials.gov Identifier: #NCT05322122.
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MAS significantly decreases BMI from 44.08 ± 3.29 kg/m2 to 28.69 ± 3.9 kg/m2 at one year in a 10-patient trial.
“A recently completed clinical trial involving 10 patients reported a significant decrease in BMI, from 44.08 ± 3.29 kg/m2 to 28.69 ± 3.9 kg/m2 at one year (p < 0.001).”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [109]
All patients discontinued antihypertensive, antidiabetic, and statin medications after MAS.
“Additionally, all patients discontinued their antihypertensive, antidiabetic, and statin medications post-procedure [109].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [109]
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Tasabehji, D., Saleh, S., & Mokadem, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124012 · Cited by 14
Metadata
- Authors
- Dziakova, J., Torres, A., Odovic, M., Esteban, J. M., Vázquez-Romero, M., Castillo, A., Sánchez-Pernaute, A., & Gagner, M.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Hospital Clínico San Carlos (ES)
- Hôpital du Sacré-Cœur de Montréal (CA)
- ORCID
- Venue
- Obesity Surgery
- Published
- 2024-08-02
- Volume
- 34
- Issue
- 9
- Pages
- 3569-3575
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W4401250605
- Cited by
- 13
- References
- 1
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 1
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- GT Metabolic Solutions
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Health Sciences › Medicine › Surgery › Body Contouring and Surgery
- Keywords
- sleeve gastrectomy
- MeSH terms
- Adult, Anastomosis, Surgical, Duodenum, Feasibility Studies, Female, Follow-Up Studies, Gastrectomy, Humans, Male, Middle Aged, Obesity, Morbid, Spain, Weight Loss, Treatment Outcome, Magnets
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