Discontinuation of tirzepatide and semaglutide prior to gastric sleeve surgery: clinical considerations and guidelines
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Some effects, such as delayed gastric emptying, reverse quickly through restored antral motility, and central anorexigenic signaling may downregulate soon after GLP-1R stimulation ends.
“Some effects, such as delayed gastric emptying, reverse quickly through restored antral motility,31 and central anorexigenic signaling in the hypothalamus may downregulate soon after GLP-1R stimulation ends.32”
From Metabolic rebound after GLP-1 receptor agonist discontinuation: a systematic review and meta-analysis (2025) · cites this paper as [31]
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Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms
I˙meryüz, N., Yeğen, B. Ç., Bozkurt, A., Coşkun, T., Villanueva-Peñacarrillo, M. L., & Ulusoy, N. B. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.4.g920 · Cited by 432 · see citing works
Meloni, A. R., DeYoung, M. B., Lowe, C., & Parkes, D. G. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01663.x · Cited by 407 · see citing works
Halim, M. A., Degerblad, M., Sundbom, M., Karlbom, U., Holst, J. J., Webb, D., & Hellström, P. M. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02006 · Cited by 104 · see citing works
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Tzang, C.-C., Wu, P.-H., Luo, C.-A., Chen, Z.-T., Lee, Y.-T., Huang, E. S., Kang, Y.-F., Lin, W.-C., Tzang, B.-S., & Hsu, T.-C. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103680 · Cited by 73 · see citing works
- Authors
- Kassir, R., Ezzat, A., & Fakhro, J.
- Affiliations
- Qatar University (QA)
- Corresponding author
- Kassir, Radwan
- ORCID
- Kassir, Radwan
- Venue
- Obesity Surgery
- Published
- 2025-03-31
- Volume
- 35
- Issue
- 5
- Pages
- 1579-1580
- ISSN
- 0960-8923 (ISSN-L)
- 1708-0428
- OpenAlex
- W4408993513
- Cited by
- 1
- References
- 3
- Citations by year
- 2025: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Obesity Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- tirzepatide, semaglutide
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