Identification and expression of mammalian long‐chain PUFA elongation enzymes

Leonard, Amanda E.; Kelder, Bruce; Bobik, Emil G.; Chuang, Lu‐Te; Lewis, Christopher J.; Kopchick, John J.; Mukerji, Pradip; Huang, Yung‐Sheng

doi:10.1007/s11745-002-0955-6

Identification and expression of mammalian long‐chain PUFA elongation enzymes

In mammalian cells, Sprecher has proposed that the synthesis of long-chain PUFA from the 20-carbon substrates involves two consecutive elongation steps, a delta6-desaturation step followed by retroconversion (Sprecher, H., Biochim. Biophys. Acta 1486, 219-231, 2000). We searched the database usin…