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Antioxidants from a heated histidine‐glucose model system. I: Investigation of the antioxidant role of histidine and isolation of antioxidants by high‐performance liquid chromatography
Abstract
The radical‐combining activity of Maillard reaction products [MRP(aq)], produced by heating d‐glucose and l‐histidine (3:1) in a 0.1 M phosphate buffer for 10 h at 105°C (final pH 6.53), was estimated directly by means of a diphenylpicrylhydrazyl radical (DPPH·) method. Additionally, the indirect methods of peroxide values changes (oven test), hexanal formation, and protection factors (Rancimat method) were determined on a lipid model system that consisted of sunflower seed oil/water (1:2), emulsified with 3% (w/w) Tween 40. Results from the DPPH· method showed a potential antioxidant activity of MRP(aq), which was confirmed by the indirect methods. Surprisingly, histidine in solution alone (heated or not) exhibited an antioxidant activity greater than or similar to the MRP(aq) activity in the indirect methods with the lipid model system, in contrast to the results from the DPPH· method. The suitability of various solvents for extraction of potential antioxidant compounds from freeze‐dried MRP(aq) was examined, and ethanol extracts showed the greatest activity by the DPPH· method. Consequently, the ethanol extract of freeze‐dried MRP(aq) was separated by means of preparative reverse‐phase high‐performance liquid chromatography (HPLC) with a 0.05 M phosphate buffer (pH 4.4)/water/acetonitrile gradient system. The antioxidant activity of the eluate was measured through the DPPH· method, and a fraction (Fraction A) with antiradical activity was further purified by preparative HPLC. Fraction B was collected, and its freeze‐dried residue exhibited potent antiradical activity, significantly greater than that of the same level of n‐propyl gallate.
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Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.
Kohen, R., Yamamoto, Y., Cundy, K. C., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3175 · Cited by 794
Cited by
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Younes, I., Hajji, S., Frachet, V., Rinaudo, M., Jellouli, K., & Nasri, M. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.06.013 · Cited by 324
Barkallah, M., Dammak, M., Louati, I., Hentati, F., Hadrich, B., Mechichi, T., Ayadi, M. A., Fendri, I., Attia, H., & Abdelkafi, S. (2017) · LWT · doi:10.1016/j.lwt.2017.05.071 · Cited by 274
Kallel, F., Driss, D., Chaari, F., Belghith, L., Bouaziz, F., Ghorbel, R., & Chaabouni, S. E. (2014) · Industrial Crops and Products · doi:10.1016/j.indcrop.2014.07.047 · Cited by 181
Trabelsi, I., Ktari, N., Ben Slima, S., Triki, M., Bardaa, S., Mnif, H., & Ben Salah, R. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.05.017 · Cited by 128
Metadata
- Authors
- Bersuder, P., Hole, M., & Smith, G.
- Venue
- Journal of the American Oil Chemists' Society
- Publisher
- Wiley
- Published
- 1998-02
- Volume
- 75
- Issue
- 2
- Pages
- 181-187
- ISSN
- 0003-021X (ISSN-L)
- 1558-9331
- OpenAlex
- W2028579939
- Cited by
- 490
- References
- 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bersuder, P., Hole, M., & Smith, G. (1998). Antioxidants from a heated histidine‐glucose model system. I: Investigation of the antioxidant role of histidine and isolation of antioxidants by high‐performance liquid chromatography. Journal of the American Oil Chemists' Society. https://doi.org/10.1007/s11746-998-0030-y
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