Cited by 128Polysaccharides Composition and ApplicationsWound Healing and TreatmentsSeaweed-derived Bioactive Compounds

Evaluation of Dermal Wound Healing Activity and in Vitro Antibacterial and Antioxidant Activities of a New Exopolysaccharide Produced by Lactobacillus sp.Ca6

Trabelsi, Imen, Ktari, Naourez, Ben Slima, Sirine, Triki, Mehdi, Bardaa, Sana, Mnif, Hela, Ben Salah, Riadh·2017·International Journal of Biological Macromolecules

Abstract

The present study aimed to evaluate the in vitro antibacterial and antioxidant activities and the in vivo wound healing performance of a noval exopolysaccharides (EPS-Ca 6) produced by Lactobacillus sp.Ca 6 strain. The results showed that EPS-Ca 6 had a potential antioxidant activity determined through four different assays: DPPH scavenging activity, reducing power, β-carotene bleaching by linoleic acid assay, and Metal chelating activities. It also exhibited significant antibacterial activity against pathogenic bacteria Salmonella enterica and Micrococcus luteus. The wound healing activity of the EPS-Ca 6, using excision wound model in rats, showed that this novel EPS accelerated significantly wound healing activity as compared to the control group, and a total closure was achieved after 14days of wound induction. Furthermore, histological examination of biopsies showed fully re-epithelialized wound with a complete epidermal regeneration. Overall the finding indicates that the EPS-Ca 6 might be useful as a wound healing agent in modern medicine.

Integrity signals

Registry

Crossref · 10.1016/j.ijbiomac.2017.05.017

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38 of 38 references verified0 citation errors · 0 not checkable

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  • Mechanisms by which bacterial EPS can exert antioxidant activity may include degradation of superoxide anion and hydrogen peroxide through ROS scavenging activity, inhibition of lipid peroxidation, reduction of metal ion chelating activity, and up-regulation of enzymatic and non-enzymatic antioxidant activities.

    “the mechanisms by which bacterial EPS can exert antioxidant activity may include degradation of superoxide anion and hydrogen peroxide through ROS scavenging activity, inhibition of lipid peroxidation, reduction of metal ion chelating activity as well as up-regulation of enzymatic and non-enzymatic antioxidant activities [115,116,117].”
  • Salmonella enterica ATCC 43972 and Micrococcus luteus were effectively inhibited by EPS-Ca6 isolated from Lactobacillus sp. Ca6.

    “Salmonella enterica ATCC 43972 and Micrococcus luteus were effectively inhibited by EPS-Ca6 isolated from Lactobacillus sp. Ca6 [117].”

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Authors
Trabelsi, I., Ktari, N., Ben Slima, S., Triki, M., Bardaa, S., Mnif, H., & Ben Salah, R.
Affiliations
  • Centre of Biotechnology of Sfax (TN)
  • University of Sfax (TN)
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2017-10
Volume
103
Pages
194-201
ISSN
0141-8130 (ISSN-L)
OpenAlex
W2612545042
Cited by
128
References
38
Citations by year
2026: 16 · 2025: 20 · 2024: 18 · 2023: 15 · 2022: 27 · 2021: 14 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 2
FWCI
5.53
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Biological Macromolecules (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Higher Education and Scientific Research, Tunisia
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords
exopolysaccharides, Lactobacillus, wound healing, antibacterial activity, antioxidant activity, Salmonella enterica, Micrococcus luteus, excision wound, re-epithelialization, epidermal regeneration, DPPH radical scavenging, metal chelating activity, reducing power, β-carotene bleaching
MeSH terms
Animals, Anti-Bacterial Agents, Antioxidants, Body Weight, Chelating Agents, Hydroxyproline, Lactobacillus, Male, Polysaccharides, Bacterial, Skin, Wound Healing, Rats, Wistar, Rats

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