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Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy
Abstract
Purpose Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains.Methods Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months. Associations between neuropsychological and FACT-COG scores were explored: perceived cognitive impairment (PCI), perceived cognitive ability (PCA), impact of PCI on quality of life (CogQOL).Results Of 362 CRC subjects, 289 had loco-regional disease and 173 received chemotherapy (CTh+). At baseline, groups did not differ on total FACT-COG, PCI, or PCA scores. All scores, except PCA, were worse at 6 months in CTh+. CRC patients not receiving chemotherapy did not differ from controls on FACT-COG domains. PCA associated weakly (r = 0.28-0.34) with attention/executive function, visual memory, and global deficit score. There was no association between PCI and neuropsychological domains. Fatigue, anxiety/depression, and poorer quality of life were associated with PCI and CogQOL (r = 0.44-0.51) in CRC patients.Conclusions No association was seen between total FACT-COG or PCI, and neuropsychological domains. A weak-moderate association was found between PCA and attention/executive function and visual memory.Trial registration The study was registered with clinicaltrials.gov (trial registration: NCT00188331).Implications for cancer survivors Cognitive symptoms are associated with fatigue, anxiety/depression, and poorer quality of life, and do not appear to be related to actual cognitive performance. Rates were lower than that reported in breast cancer survivors. Cognitive symptoms were greatest in those who received chemotherapy, with no significant difference between the non-chemotherapy survivors and healthy controls.
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Cognitive impairment significantly impacts quality of life and interferes with daily functioning in cancer survivors.
“cognitive impairment has been found to significantly impact quality of life and to interfere with daily functioning (Dhillon et al., 2018).”
From The relationship between acceptance, fatigue, and subjective cognitive impairment in hematologic cancer survivors (2019) · cites this paper as Dhillon et al., 2018
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Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005
Wefel, J. S., Vardy, J. L., Ahles, T. A., & Schagen, S. B. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70294-1 · Cited by 1,004
Self-citationBoykoff, N., Moieni, M., & Subramanian, S. K. (2009) · Journal of Cancer Survivorship · doi:10.1007/s11764-009-0098-x · Cited by 523
Objective and subjective cognitive impairment following chemotherapy for cancer: A systematic review
Hutchinson, A. D., Hosking, J. R., Kichenadasse, G., Mattiske, J. K., & Wilson, C. J. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.05.002 · Cited by 467
Janelsins, M. C., Heckler, C. E., Peppone, L. J., Kamen, C. S., Mustian, K. M., Mohile, S. G., Magnuson, A. M., Kleckner, I. R., Guido, J. J., Young, K. L., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.68.5826 · Cited by 393
An Update on Cancer- and Chemotherapy-Related Cognitive Dysfunction: Current Status
Janelsins, M. C., Kohli, S., Mohile, S. G., Usuki, K. Y., Ahles, T. A., & Morrow, G. R. (2011) · Seminars in Oncology · doi:10.1053/j.seminoncol.2011.03.014 · Cited by 363
Vardy, J. L., Dhillon, H. M., Pond, G. R., Rourke, S. B., Bekele, T., Renton, C., Dodd, A., Zhang, H., Beale, P. J., Clarke, S. J., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.63.0905 · Cited by 271
Self-citationSelf-reported cognitive concerns and abilities: two sides of one coin?
Lai, J., Wagner, L. I., Jacobsen, P. B., & Cella, D. F. (2014) · Psycho-Oncology · doi:10.1002/pon.3522 · Cited by 235
Ganz, P. A., Kwan, L. C., Castellon, S. A., Oppenheim, A., Bower, J. E., Silverman, D. H. S., Cole, S. W., Irwin, M. R., Ancoli‐Israel, S., & Belin, T. R. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt073 · Cited by 221
Ah, D. M. V., & Tallman, E. F. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2014.08.012 · Cited by 145
Cognitive function and fatigue after diagnosis of colorectal cancer
Vardy, J. L., Dhillon, H. M., Pond, G. R., Rourke, S. B., Xu, W., Dodd, A., Renton, C., Park, A. M.-G., Bekele, T., Ringash, J. G., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu448 · Cited by 143
Self-citationDownie, F. P., Fan, H. M., Tchen, N., Yi, Q., & Tannock, I. F. (2006) · Psycho-Oncology · doi:10.1002/pon.1035 · Cited by 133
Self-citationEvaluating the Dimensionality of Perceived Cognitive Function
Lai, J., Butt, Z. A., Wagner, L. I., Sweet, J. J., Beaumont, J. L., Vardy, J. L., Jacobsen, P. B., Shapiro, P. J., Jacobs, S. R., & Cella, D. F. (2009) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2008.07.012 · Cited by 95
Self-citationMandelblatt, J. S., Clapp, J. D., Luta, G., Faul, L. A., Tallarico, M., McClendon, T. D., Whitley, J. A., Cai, L., Ahles, T. A., Stern, R. A., et al. (2016) · Cancer · doi:10.1002/cncr.30208 · Cited by 91
Vardy, J. L., Dhillon, H. M., Pond, G. R., Renton, C., Dodd, A., Zhang, H. A., Clarke, S. J., & Tannock, I. F. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw252 · Cited by 91
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Research works printed but not linked: 1
- Wagner L, Sweet J, Butt Z, et al. Measuring patient self-reported cognitive function: development of the Functional Assessment of Cancer Therapy - Cognitive Function instrument. J Support Oncol. 2009;7:W32–9.
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Kuba, K., Weißflog, G., Götze, H., García-Torres, F., Mehnert, A., & Esser, P. (2019) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2018.12.001 · Cited by 26
Metadata
- Authors
- Dhillon, H. M., Tannock, I. F., Pond, G. R., Renton, C., Rourke, S. B., & Vardy, J. L.
- Affiliations
- The University of Sydney (AU)
- University of Toronto (CA)
- Juravinski Cancer Centre (CA)
- St. Michael's Hospital (CA)
- Corresponding author
- Vardy, Janette L.
- Venue
- Journal of Cancer Survivorship
- Published
- 2017-10-27
- Volume
- 12
- Issue
- 2
- Pages
- 178-185
- ISSN
- 1932-2259 (ISSN-L)
- 1932-2267
- OpenAlex
- W2766974806
- Cited by
- 88
- References
- 15
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 12 · 2023: 8 · 2022: 22 · 2021: 12 · 2020: 8 · 2019: 7 · 2017: 1
- FWCI
- 3.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cancer Survivorship (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute of Canada (#15261)
- American Society of Clinical Oncology (Young Investigator Award)
- National Health and Medical Research Council (457386)
- Cancer Institute NSW (05/CRF/1-06, 09/RIG1-13)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- colorectal cancer, perceived cognitive impairment, chemotherapy, cognitive symptoms, neuropsychological assessment, FACT-Cog, quality of life, fatigue, anxiety and depression, attention and executive function, visual memory, cancer survivors
- MeSH terms
- Cancer Survivors, Adult, Aged, Antineoplastic Agents, Cognition, Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Perception, Quality of Life, Colorectal Neoplasms, Case-Control Studies, Young Adult, Cognitive Dysfunction
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