The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: Beyond Vasospasm and Towards a Multifactorial Pathophysiology
Open accessAbstract
Purpose of ReviewDelayed cerebral ischemia (DCI) is common after subarachnoid hemorrhage (SAH) and represents a significant cause of poor functional outcome. DCI was mainly thought to be caused by cerebral vasospasm; however, recent clinical trials have been unable to confirm this hypothesis. Studies in humans and animal models have since supported the notion of a multifactorial pathophysiology of DCI. This review summarizes some of the main mechanisms under investigation including cerebral vascular dysregulation, microthrombosis, cortical spreading depolarizations, and neuroinflammation.Recent FindingsRecent guidelines have differentiated between DCI and angiographic vasospasm and have highlighted roles of the microvasculature, coagulation and fibrinolytic systems, cortical spreading depressions, and the contribution of the immune system to DCI. Many therapeutic interventions are underway in both preclinical and clinical studies to target these novel mechanisms as well as studies connecting these mechanisms to one another.SummaryClinical trials to date have been largely unsuccessful at preventing or treating DCI after SAH. The only successful pharmacologic intervention is the calcium channel antagonist, nimodipine. Recent studies have provided evidence that cerebral vasospasm is not the sole contributor to DCI and that additional mechanisms may play equal if not more important roles.
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Cited by
Spontaneous subarachnoid haemorrhage
Claassen, J., & Park, S. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00938-2 · Cited by 587
Metadata
- Authors
- Geraghty, J. R., & Testai, F. D.
- Venue
- Current Atherosclerosis Reports
- Published
- 2017-10-23
- Volume
- 19
- Issue
- 12
- Pages
- 50-50
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- OpenAlex
- W2766783053
- Cited by
- 304
- References
- 93
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Geraghty, J. R., & Testai, F. D. (2017). Delayed Cerebral Ischemia after Subarachnoid Hemorrhage: Beyond Vasospasm and Towards a Multifactorial Pathophysiology. Current Atherosclerosis Reports. https://doi.org/10.1007/s11883-017-0690-x
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