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The Role of Adverse Childhood Experiences in Cardiovascular Disease Risk: a Review with Emphasis on Plausible Mechanisms
Open accessAbstract
Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.
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“Emerging epidemiologic evidence strongly supports that ELS/CT is an independent albeit silent risk factor of future chronic cardiovascular risk through various systemic and molecular mechanisms (267–272)”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [271]
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Metadata
- Authors
- Su, S., Jimenez, M. P., Roberts, C. T. F., & Loucks, E. B.
- Affiliations
- Augusta University (US)
- Brown University (US)
- Corresponding author
- Su, Shaoyong
- Venue
- Current Cardiology Reports
- Published
- 2015-08-20
- Volume
- 17
- Issue
- 10
- Pages
- 88-88
- ISSN
- 1523-3782 (ISSN-L)
- 1534-3170
- PMC
- PMC4941633
- OpenAlex
- W1193057051
- Semantic Scholar
- 7f2d7686921b6c238a884894b1a2dfacd08c21fe
- Cited by
- 242
- References
- 120
- Citations by year
- 2026: 17 · 2025: 21 · 2024: 30 · 2023: 31 · 2022: 34 · 2021: 38 · 2020: 26 · 2019: 16 · 2018: 13 · 2017: 10 · 2016: 5
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Cardiology Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG048825, RC2AG036666)
- National Heart, Lung, and Blood Institute (R01HL125577)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007338)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Health › Intimate Partner and Family Violence
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- adverse childhood experiences, childhood abuse, child neglect, household dysfunction, cardiovascular risk, cardiovascular risk factors, biological pathways, epigenetics, developmental origins of health and disease, public health implications
- MeSH terms
- Adaptation, Physiological, Adaptation, Psychological, Adult, Cardiovascular Diseases, Child, Child Abuse, Depression, Diabetes Mellitus, Type 2, Humans, Life Change Events, Obesity, Risk Factors, Time Factors, Prevalence, Crime Victims, Substance-Related Disorders
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