Cited by 242Child Abuse and TraumaIntimate Partner and Family ViolenceChild Welfare and Adoption

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The Role of Adverse Childhood Experiences in Cardiovascular Disease Risk: a Review with Emphasis on Plausible Mechanisms

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Su, Shaoyong, Jimenez, Marcia P., Roberts, Cole T. F., Loucks, Eric B.·2015·Current Cardiology Reports

DOI 10.1007/s11886-015-0645-1PMC PMC4941633

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Abstract

Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.

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Authors: Su, S., Jimenez, M. P., Roberts, C. T. F., & Loucks, E. B.
Affiliations: Augusta University (US)
Brown University (US)
Corresponding author: Su, Shaoyong
ORCID: Su, Shaoyong
Jimenez, Marcia P.
Loucks, Eric B.
Venue: Current Cardiology Reports
Publisher: Springer Science and Business Media LLC
Published: 2015-08-20
Volume: 17
Issue: 10
Pages: 88-88
ISSN: 1523-3782 (ISSN-L)
1534-3170
DOI: 10.1007/s11886-015-0645-1
PMC: PMC4941633
OpenAlex: W1193057051
Semantic Scholar: 7f2d7686921b6c238a884894b1a2dfacd08c21fe
Cited by: 242
References: 120
Citations by year: 2026: 17 · 2025: 21 · 2024: 30 · 2023: 31 · 2022: 34 · 2021: 38 · 2020: 26 · 2019: 16 · 2018: 13 · 2017: 10 · 2016: 5
FWCI: 1.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Cardiology Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG048825, RC2AG036666)
National Heart, Lung, and Blood Institute (R01HL125577)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007338)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Health › Intimate Partner and Family Violence
Social Sciences › Sociology and Political Science › Child Welfare and Adoption
Keywords: adverse childhood experiences, childhood abuse, child neglect, household dysfunction, cardiovascular risk, cardiovascular risk factors, biological pathways, epigenetics, developmental origins of health and disease, public health implications
MeSH terms: Adaptation, Physiological, Adaptation, Psychological, Adult, Cardiovascular Diseases, Child, Child Abuse, Depression, Diabetes Mellitus, Type 2, Humans, Life Change Events, Obesity, Risk Factors, Time Factors, Prevalence, Crime Victims, Substance-Related Disorders

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