Insights on pathogenesis of type 2 diabetes from MODY genetics

A haplotype map of the human genome

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The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M.-C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000) · Nature Genetics · doi:10.1038/79216 · Cited by 1,766 · see citing works

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R., Lathrop, M. G., Boriraj, V. V., et al. (1996) · Nature · doi:10.1038/384455a0 · Cited by 1,610 · see citing works

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

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Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Gloyn, A. L., Pearson, E. R., Antcliff, J. F., Proks, P., Bruining, G. J., Slingerland, A. S., Howard, N., Srinivasan, S., Silva, J. M. C. L., Molnes, J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032922 · Cited by 1,137 · see citing works

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)

Yamagata, K., Furuta, H., Oda, N., Kaisaki, P. J., Menzel, S., Cox, N. J., Fajans, S. S., Signorini, S. G., Stoffel, M., & Bell, G. I. (1996) · Nature · doi:10.1038/384458a0 · Cited by 975 · see citing works

Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1

Staffers, D. A., Ferrer, J. P., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng1097-138 · Cited by 880 · see citing works

Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY

Horikawa, Y., Iwasaki, N., Hara, M., Furuta, H., Hinokio, Y., Cockburn, B. N., Lindner, T. H., Yamagata, K., Ogata, M., Tomonaga, O., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-384 · Cited by 878 · see citing works

Guilt by association

Altshuler, D., Daly, M. J., & Kruglyak, L. (2000) · Nature Genetics · doi:10.1038/79839 · Cited by 762 · see citing works

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

Malecki, M. T., Jhala, U. S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M. F., Warram, J. H., Montminy, M., & Królewski, A. S. (1999) · Nature Genetics · doi:10.1038/15500 · Cited by 619 · see citing works

Genetic cause of hyperglycaemia and response to treatment in diabetes

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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

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Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy

Thomas, P. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.11.1809 · Cited by 443 · see citing works

Linkage of type 2 diabetes to the glucokinase gene

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Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families

Mahtani, M. M., Widén, E., Lehto, M. J., Thomas, J. D., McCarthy, M. I., Brayer, J., Bryant, B. M., Chan, G., Daly, M. J., Forsblom, C. M., et al. (1996) · Nature Genetics · doi:10.1038/ng0996-90 · Cited by 323 · see citing works

Haplotype Structure and Genotype-Phenotype Correlations of the Sulfonylurea Receptor and the Islet ATP-Sensitive Potassium Channel Gene Region

Florez, J. C., Burtt, N. P., de Bakker, P. I. W., Almgren, P., Tuomi, T., Holmkvist, J., Gaudet, D., Hudson, T. J., Schaffner, S. F., Daly, M. J., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1360 · Cited by 307 · see citing works

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

Matschinsky, F. M., Liang, Y. T., Kesavan, P., Wang, L., Froguel, P., Velho, G., Cohen, D., Permutt, M. A., Tanizawa, Y., & Jetton, T. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116809 · Cited by 287 · see citing works

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

Hani, E. H., Stoffers, D. A., Chèvre, J.-C., Durand, E., Stanojevic, V., Christian Dina, C., Habener, J. F., & Froguel, P. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7469 · Cited by 281 · see citing works

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.

Frayling, T. M., Evans, J., Bulman, M., Pearson, E. R., Allen, L. I. S., Owen, K. R., Bingham, C., Hannemann, M. M., Shepherd, M. H., Ellard, S., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s94 · Cited by 276 · see citing works

The genetic abnormality in the beta cell determines the response to an oral glucose load

Stride, A., Vaxillaire, M., Tuomi, T., Barbetti, F., Njølstad, P. R., Hansen, T. F., Costa, A., Conget, I., Pedersen, O. B., Søvik, O., et al. (2002) · Diabetologia · doi:10.1007/s00125-001-0770-9 · Cited by 275 · see citing works

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

Weedon, M. N., McCarthy, M. I., Hitman, G. A., Walker, M., Groves, C. J., Zeggini, E., Rayner, N. W., Shields, B. M., Owen, K. R., Hattersley, A. T., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030374 · Cited by 266 · see citing works

Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes

Silander, K., Mohlke, K. L., Scott, L. J., Peck, E. C., Hollstein, P. E., Skol, A. D., Jackson, A., Deloukas, P., Hunt, S. E., Stavrides, G., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1141 · Cited by 266 · see citing works

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Byrne, M. M., Sturis, J., Menzel, S., Yamagata, K., Fajans, S. S., Dronsfield, M. J., Bain, S. C., Hattersley, A. T., Velho, G., Froguel, P., et al. (1996) · Diabetes · doi:10.2337/diab.45.11.1503 · Cited by 259 · see citing works

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

Macfarlane, W. M., Frayling, T. M., Ellard, S., Evans, J., Allen, L. I. S., Bulman, M. P., Ayres, S., Shepherd, M. H., Clark, P. M. S., Millward, A. B., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7449 · Cited by 251 · see citing works

Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4α mutations in a large European collection

Pearson, E. R., Průhová, Š., Tack, C. J., Johansen, A., Castleden, H., Lumb, P. J., Wierzbicki, A. S., CLARK, P. M. S., Lebl, J., Pedersen, O. B., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1738-y · Cited by 231 · see citing works

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

Macfarlane, W. M., McKinnon, C. M., Felton-Edkins, Z. A., Cragg, H., James, R. F. L., & Docherty, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1011 · Cited by 219 · see citing works

A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated With Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population

Love-Gregory, L. D., Wasson, J. C., Ma, J., Jin, C. H., Gläser, B., Suarez, B. K., & Permutt, M. A. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1134 · Cited by 218 · see citing works

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

Thomas, H. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.19.2089 · Cited by 215 · see citing works

Localization of a Susceptibility Gene for Type 2 Diabetes to Chromosome 5q34–q35.2

Reynisdóttir, I., Þorleifsson, G., Benediktsson, R., Sigurdsson, G. T., Emilsson, V., Einarsdottir, A., Hjörleifsdóttir, E. E., Orlygsdottir, G., Bjornsdottir, G., Saemundsdottir, J., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/377139 · Cited by 198 · see citing works

Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the young

Ellard, S., & Colclough, K. (2006) · Human Mutation · doi:10.1002/humu.20357 · Cited by 191 · see citing works

The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells

Macfarlane, W. M., Smith, S. B., James, R. F. L., Clifton, A. D., Doza, Y. N., Cohen, P., & Docherty, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20936 · Cited by 176 · see citing works

Different genes, different diabetes: lessons from maturity-onset diabetes of the young

Stride, A., & Hattersley, A. T. (2002) · Annals of Medicine · doi:10.1080/ann.34.3.207.217 · Cited by 162 · see citing works

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

Owen, K. R., & Hattersley, A. T. (2001) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2001.0148 · Cited by 152 · see citing works

The Hepatic Nuclear Factor-1α G319S Variant Is Associated with Early-Onset Type 2 Diabetes in Canadian Oji-Cree1

Hegele, R. A., Cao, H., Harris, S. B., Hanley, A. J., & Zinman, B. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5528 · Cited by 144 · see citing works

Contrasting Diabetes Phenotypes Associated With Hepatocyte Nuclear Factor-1α and -1β Mutations

Pearson, E. R., Badman, M. K., Lockwood, C. R., CLARK, P. M. S., Ellard, S., Bingham, C., & Hattersley, A. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1102 · Cited by 132 · see citing works

A Common Haplotype of the Glucokinase Gene Alters Fasting Glucose and Birth Weight: Association in Six Studies and Population-Genetics Analyses

Weedon, M. N., Clark, V. J., Qian, Y., Ben‐Shlomo, Y., Timpson, N. J., Ebrahim, S. B. J., Lawlor, D. A., Pembrey, M. E., Ring, S. M., Wilkin, T. J., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/509517 · Cited by 125 · see citing works

Growing evidence for diabetes susceptibility genes from genome scan data

McCarthy, M. I. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0040-y · Cited by 119 · see citing works

HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community

Triggs‐Raine, B. L., Kirkpatrick, R. D., Kelly, S. L., Norquay, L., Cattini, P. A., Yamagata, K., Hanley, A. J., Zinman, B., Harris, S. B., Barrett, P. H. R., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062059799 · Cited by 118 · see citing works

MODY in Iceland is associated with mutations in HNF -1? and a novel mutation in NeuroD1

Kristinsson, S. Y., Talseth‐Palmer, B. A., Steingrı́msson, E., Þórsson, Á. V., Helgason, T., Hreidarsson, Á. B., Thorolfsdottir, E. T., & Arngrı́msson, R. (2001) · Diabetologia · doi:10.1007/s001250100016 · Cited by 110 · see citing works

Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene

Weedon, M. N., Frayling, T. M., Shields, B. M., Knight, B. A., Turner, T., Metcalf, B. S., Voss, L. D., Wilkin, T. J., McCarthy, A., Ben‐Shlomo, Y., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.576 · Cited by 106 · see citing works

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

Hansen, S. K., Párrizas, M., Jensen, M. L., Průhová, Š., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15085 · Cited by 104 · see citing works

Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated With Type 2 Diabetes in the U.K. Population

Weedon, M. N., Owen, K. R., Shields, B. M., Hitman, G. A., Walker, M., McCarthy, M. I., Love-Gregory, L. D., Permutt, M. A., Hattersley, A. T., & Frayling, T. M. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3002 · Cited by 95 · see citing works

The genetics of type 2 diabetes

Gloyn, A. L., & McCarthy, M. I. (2001) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2001.0147 · Cited by 82 · see citing works

Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns

Bonnycastle, L. L., Willer, C. J., Conneely, K. N., Jackson, A., Burrill, C. P., Watanabe, R. M., Chines, P. S., Narisu, N., Scott, L. J., Enloe, S. T., et al. (2006) · Diabetes · doi:10.2337/db06-0178 · Cited by 81 · see citing works

Association of Common Variation in the HNF1α Gene Region With Risk of Type 2 Diabetes

Winckler, W., Burtt, N. P., Holmkvist, J., Cervin, C., de Bakker, P. I. W., Sun, M. W., Almgren, P., Tuomi, T., Gaudet, D., Hudson, T. J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2336 · Cited by 78 · see citing works

Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12

Byrne, M. M., Sturis, J., Menzel, S., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.11.1503 · Cited by 78 · see citing works

Association Testing of Variants in the Hepatocyte Nuclear Factor 4α Gene With Risk of Type 2 Diabetes in 7,883 People

Winckler, W., Graham, R., de Bakker, P. I. W., Sun, M. W., Almgren, P., Tuomi, T., Gaudet, D., Hudson, T. J., Ardlie, K., Daly, M. J., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.886 · Cited by 75 · see citing works

Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY3 mutations

Weng, J., Macfarlane, W. M., Lehto, M. J., Gu, H. F., Shepherd, L. M. A., Ivarsson, S. A., Wibell, L. B., Smith, T., & Groop, L. (2001) · Diabetologia · doi:10.1007/s001250051608 · Cited by 60 · see citing works

The Hepatic Nuclear Factor-1 G319S Variant Is Associated with Early-Onset Type 2 Diabetes in Canadian Oji-Cree

Hegele, R. A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.3.1077 · Cited by 59 · see citing works

Variation near the hepatocyte nuclear factor (HNF)-4? gene associates with type 2 diabetes in the Danish population

Hansen, S. K., Rose, C. S., Gl�mer, C., Drivsholm, T., Borch‐Johnsen, K., J�rgensen, T., Pedersen, O. B., & Hansen, T. F. (2005) · Diabetologia · doi:10.1007/s00125-005-1671-0 · Cited by 57 · see citing works

A Large-Scale Association Analysis of Common Variation of the HNF1α Gene With Type 2 Diabetes in the U.K. Caucasian Population

Weedon, M. N., Owen, K. R., Shields, B. M., Hitman, G. A., Walker, M., McCarthy, M. I., Hattersley, A. T., & Frayling, T. M. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2487 · Cited by 56 · see citing works

A −30G>A Polymorphism of the β-Cell–Specific Glucokinase Promoter Associates With Hyperglycemia in the General Population of Whites

Rose, C. S., Ek, J., Urhammer, S. A., Glümer, C., Borch‐Johnsen, K., Jørgensen, T., Pedersen, O. B., & Hansen, T. F. (2005) · Diabetes · doi:10.2337/diabetes.54.10.3026 · Cited by 56 · see citing works

Genes, environment and Oji-Cree type 2 diabetes

Hegele, R. A., Zinman, B., Hanley, A. J., Harris, S. B., Barrett, P. H. R., & Cao, H. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(03)00004-3 · Cited by 55 · see citing works

Variants in Hepatocyte Nuclear Factor 4α Are Modestly Associated With Type 2 Diabetes in Pima Indians

Muller, Y. L., Infante, A. M., Hanson, R. L., Love-Gregory, L. D., Knowler, W. C., Bogardus, C., & Baier, L. J. (2005) · Diabetes · doi:10.2337/diabetes.54.10.3035 · Cited by 53 · see citing works

Missense Mutations in the Human Insulin Promoter Factor-1 Gene and Their Relation to Maturity-Onset Diabetes of the Young and Late-Onset Type 2 Diabetes Mellitus in Caucasians

Hansen, L., Urioste, S., Petersen, H. V., Jensen, J. N., Eiberg, H., Barbetti, F., Serup, P., Hansen, T. F., & Pedersen, O. B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6421 · Cited by 50 · see citing works

G(−30)A Polymorphism in the Pancreatic Promoter of the Glucokinase Gene Associated With Angiographic Coronary Artery Disease and Type 2 Diabetes Mellitus

März, W., Nauck, M., Hoffmann, M. M., Nagel, D. W., Boehm, B. O., Köenig, W., Rothenbacher, D., & Winkelmann, B. R. (2004) · Circulation · doi:10.1161/01.cir.0000129306.44085.c4 · Cited by 46 · see citing works

Genetic variation in the hepatocyte nuclear factor-1a gene in Danish Caucasians with late-onset NIDDM

Urhammer, S. A., Rasmussen, S. K., Kaisaki, P. J., Oda, N., Yamagata, K., Møller, A. M., Fridberg, M., Hansen, L., Hansen, T. F., Bell, G. I., et al. (1997) · Diabetologia · doi:10.1007/s001250050703 · Cited by 44 · see citing works

A Hepatocyte Nuclear Factor-4α Gene (HNF4A) P2 Promoter Haplotype Linked With Late-Onset Diabetes

Ræder, H., Bjørkhaug, L., Johansson, S., Mangseth, K., Sagen, J. V., Hunting, A., Følling, I., Johansen, O. E., Bjørgaas, M. R., Paus, P. N., et al. (2006) · Diabetes · doi:10.2337/db05-1677 · Cited by 36 · see citing works

The role of HNF4A variants in the risk of type 2 diabetes

Mohlke, K. L., & Boehnke, M. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0043-y · Cited by 35 · see citing works

Hepatocyte Nuclear Factor-4α P2 Promoter Haplotypes Are Associated With Type 2 Diabetes in the Japanese Population

Hara, K., Horikoshi, M., Kitazato, H., Ito, C., Noda, M., Ohashi, J., Froguel, P., Tokunaga, K., Tobe, K., Nagai, R., et al. (2006) · Diabetes · doi:10.2337/db05-0620 · Cited by 33 · see citing works

Mutations in the insulin promoter factor-1 gene in late-onset type 2 diabetes mellitus

Reis, A., Ye, W., Dubois‐Laforgue, D., Bellanné‐Chantelot, C., Timsit, J., & Velho, G. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430511 · Cited by 25 · see citing works

Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes

Vella, A. V., Howson, J. M. M., Barratt, B. J., Twells, R. C. J., Rance, H. E., Nutland, S. L., Tuomilehto‐Wolf, E., Tuomilehto, J., Undlien, D. E., Rønningen, K. S., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1158 · Cited by 23 · see citing works

Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis

Kavvoura, F. K., & Ioannidis, J. P. A. (2004) · Human Genetics · doi:10.1007/s00439-004-1224-5 · Cited by 17 · see citing works

Does the Aspartic Acid to Asparagine Substitution at Position 76 in the Pancreas Duodenum Homeobox Gene (PDX1) Cause Late-Onset Type 2 Diabetes?

Elbein, S. C., & Karim, M. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1968 · Cited by 15 · see citing works

Hepatocyte nuclear factor-1 a gene and non-insulin-dependent diabetes mellitus in the Japanese population

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Studies of the variability of the hepatocyte nuclear factor-1β (HNF-1β / TCF2) and the dimerization cofactor of HNF-1 (DcoH / PCBD) genes in relation to type 2 diabetes mellitus and β-cell function

Ek, J., Grarup, N., Urhammer, S. A., Gæde, P., Drivsholm, T., Borch‐Johnsen, K., Hansen, T., & Pedersen, O. B. (2001) · Human Mutation · doi:10.1002/humu.1201 · Cited by 9 · see citing works

IPF-1 Gene Variation and the Development of Type 2 Diabetes

Silver, K. D., & Shetty, A. (2002) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3291 · Cited by 8 · see citing works

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes

Owen, K. R., Evans, J., McCarthy, M. I., Walker, M., Hitman, G. A., Frayling, T. M., & Hattersley, A. T. (2004) · Diabetologia · doi:10.1007/s00125-004-1397-4 · Cited by 6 · see citing works

Genetic evidence that HNF-1α–dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function

Hansen, S. K., Párrizas, M., Jensen, M. L., Průhová, Š., Ek, J., Boj, S. F., Johansen, A., Maestro, M. A., Rivera, F., Eiberg, H., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215085 · Cited by 5 · see citing works

Chapter 1 Transcription factor genes in type 2 diabetes

Weedon, M. N., Hattersley, A. T., & Frayling, T. M. (2006) · Advances in molecular and cellular endocrinology · doi:10.1016/s1569-2566(06)05001-0 · Cited by 3 · see citing works

Missense mutations in the human insulin promoter factor-1 gene are not a common cause of Type 2 diabetes mellitus in Taiwan

Shiau, M., Huang, C., Liao, J.-H., & Chang, Y.-H. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345313 · Cited by 3 · see citing works

Rare and common variants: twenty arguments

Gibson, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3118 · Cited by 1,278 · see citing works

Glucokinase Gene Mutations: Structural and Genotype-Phenotype Analyses in MODY Children from South Italy

Tinto, N., Zagari, A., Capuano, M., Simone, A. D., Capobianco, V., Daniele, G., Giugliano, M., Spadaro, R., Franzese, A., & Sacchetti, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001870 · Cited by 52 · see citing works

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies

Pal, L. R., & Moult, J. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.04.014 · Cited by 49 · see citing works

Complete complement deficiency in a large cohort of familial systemic lupus erythematosus

Aggarwal, R., Sestak, A. L., D'Sousa, A., Dillon, S., Namjou, B., & Scofield, R. H. (2009) · Lupus · doi:10.1177/0961203309346508 · Cited by 41 · see citing works

Genome‐wide association studies (GWAS): impact on elucidating the aetiology of diabetes

Hakonarson, H. H., & Grant, S. F. A. (2011) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1221 · Cited by 33 · see citing works

Hepatic Gene Expression of the Insulin Signaling Pathway Is Altered by Administration of Persimmon Peel Extract: A DNA Microarray Study Using Type 2 Diabetic Goto-Kakizaki Rats

Izuchi, R., Nakai, Y., Takahashi, H., Ushiama, S., Okada, S., Misaka, T., & Abe, K. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102422z · Cited by 21 · see citing works

Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations

Sewell, M. F., Presley, L. H., Holland, S. H., & Catalano, P. M. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.944157 · Cited by 12 · see citing works

Genetics: how the UKPDS contributed to determining the genetic landscape of Type 2 diabetes

Gloyn, A. L., & McCarthy, M. I. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02500.x · Cited by 10 · see citing works

Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients

Khalil, R., Al-Sheyab, F., Khamaiseh, E., Abu-Halaweh, M. M., & Abder-Rahman, H. A. (2009) · Genetics and Molecular Research · doi:10.4238/vol8-2gmr597 · Cited by 9 · see citing works

The Hepatocyte nuclear factor-1 alpha (HNF1A) gene is associated with fatness and loin muscle area in the pig

Fan, B., Du, Z., & Rothschild, M. F. (2010) · animal · doi:10.1017/s175173111000087x · Cited by 9 · see citing works

Role of lipid droplets and FITM2 in beta-cell physiology and pathophysiology

Ho, C. Q. W. (2022) · doi:10.32657/10356/158047 · Cited by 1 · see citing works

ANALYSIS OF MICRORNA EXPRESSION PATTERN IN SMALL INTESTINE OF CELIAC PATIENTS

Capuano, M. (2010) · Università degli Studi di Napoli Federico II · doi:10.6092/unina/fedoa/7930

Current Perspectives in MODY Management—A Narrative Review

Deteșan, O., Custură, L. M., Kovács, B. I., Schmiedt, R. A., & Tilinca, M. C. (2021) · Timişoara Medical Journal · doi:10.35995/tmj20210204

Diabetes tipo MODY La contribución de la diabetes tipo MODY a nuestros conocimientos sobre los mecanismos moleculares que intervienen en la diabetes tipo 2

Weedon, M. N., Frayling, T. M., & Hattersley, A. T. (2016)

Maturity‐onset diabetes of the young as a model for elucidating the multifactorial origin of type 2 diabetes mellitus

Horikawa, Y. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12812 · Cited by 63 · see citing works

Research progress of association of MODY genes and type 2 diabetes

Nuli, R., Zulifeiya, S., & Mohemaiti, P. (2016) · 中国医师杂志 · doi:10.3760/cma.j.issn.1008-1372.2016.03.042

Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes

Vaxillaire, M., & Froguel, P. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0024 · Cited by 167 · see citing works

ORIGINAL ARTICLE Mutations in MODY Genes Are not Common Cause of Early-Onset Type 2 Diabetes in Mexican Families

Domínguez‐López, A., Miliar-garcía, Á., Segura-kato, Y. X., Riba, L., Esparza‐López, J., Ramı́rez-Jiménez, S., Rodríguez-torres, M., Canizales‐Quinteros, S., Cabrera-Vásquez, S., Fragoso‐Ontiveros, V., et al. (2015)