Cited by 35Blood Pressure and Hypertension StudiesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Best Strategies for Hypertension Management in Type 2 Diabetes and Obesity

Allcock, Darren M., Sowers, James R.·2010·Current Diabetes Reports

Abstract

Insulin resistance, dyslipidemia, hypertension, obesity, cardiovascular disease, and chronic kidney disease cluster together, and the incidence of all of these disease states is increasing throughout the world. Current strategies for hypertension management-including the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium antagonists, and thiazide diuretics-are effective for most patients. However, as the incidence of hypertension increases in this target population, so does that of resistant hypertension. As such, significant research and effort must be put forth to bring blood pressure to goal and delay or prevent target organ damage. Such efforts should frequently include a dihydropyridine calcium channel blocker such as amlodipine. Other agents that are currently underused in this population for the treatment of resistant hypertension include nebivolol, carvedilol, aliskiren, and aldosterone antagonists. Finally, significant potential is seen for darusentan, an endothelin antagonist, if it comes to market.

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Crossref · 10.1007/s11892-010-0100-z

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34 of 34 references verified0 citation errors · 0 not checkable

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Authors
Allcock, D. M., & Sowers, J. R.
Affiliations
University of Missouri (US)
Corresponding author
Allcock, Darren M.
Venue
Current Diabetes Reports
Published
2010-03-02
Volume
10
Issue
2
Pages
139-144
ISSN
  • 1534-4827 (ISSN-L)
  • 1539-0829
OpenAlex
W2107416606
Cited by
35
References
34
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 5
FWCI
0.65
Type
journal article
Language
en
Open access
closed
Locations
  • Current Diabetes Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
antihypertensive therapy, type 2 diabetes, obesity, resistant hypertension, insulin resistance, dyslipidemia, cardiovascular disease, chronic kidney disease, amlodipine, dihydropyridine calcium channel blockers, nebivolol, carvedilol, aliskiren, mineralocorticoid receptor antagonists, darusentan, endothelin receptor antagonists, ACE inhibitors, angiotensin receptor blockers, thiazide diuretics, calcium channel blockers
MeSH terms
Antihypertensive Agents, Diabetes Mellitus, Type 2, Goals, Humans, Hypertension, Obesity

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