Best Strategies for Hypertension Management in Type 2 Diabetes and Obesity
Abstract
Insulin resistance, dyslipidemia, hypertension, obesity, cardiovascular disease, and chronic kidney disease cluster together, and the incidence of all of these disease states is increasing throughout the world. Current strategies for hypertension management-including the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium antagonists, and thiazide diuretics-are effective for most patients. However, as the incidence of hypertension increases in this target population, so does that of resistant hypertension. As such, significant research and effort must be put forth to bring blood pressure to goal and delay or prevent target organ damage. Such efforts should frequently include a dihydropyridine calcium channel blocker such as amlodipine. Other agents that are currently underused in this population for the treatment of resistant hypertension include nebivolol, carvedilol, aliskiren, and aldosterone antagonists. Finally, significant potential is seen for darusentan, an endothelin antagonist, if it comes to market.
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ACE inhibitors, ARBs, beta-blockers, calcium channel blockers, and thiazide diuretics are all effective in lowering BP in most obese patients.
“Angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), b-blockers, calcium channel blockers (CCBs), and thiazide diuretics are all effective in lowering BP in most obese patients.167”
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- Authors
- Allcock, D. M., & Sowers, J. R.
- Affiliations
- University of Missouri (US)
- Corresponding author
- Allcock, Darren M.
- ORCID
- Sowers, James R.
- Venue
- Current Diabetes Reports
- Published
- 2010-03-02
- Volume
- 10
- Issue
- 2
- Pages
- 139-144
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- OpenAlex
- W2107416606
- Cited by
- 35
- References
- 34
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 6 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 5
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- antihypertensive therapy, type 2 diabetes, obesity, resistant hypertension, insulin resistance, dyslipidemia, cardiovascular disease, chronic kidney disease, amlodipine, dihydropyridine calcium channel blockers, nebivolol, carvedilol, aliskiren, mineralocorticoid receptor antagonists, darusentan, endothelin receptor antagonists, ACE inhibitors, angiotensin receptor blockers, thiazide diuretics, calcium channel blockers
- MeSH terms
- Antihypertensive Agents, Diabetes Mellitus, Type 2, Goals, Humans, Hypertension, Obesity
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