CoChat
Sign Up
Cited by 328Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians

Open access
Yabe, Daisuke, Seino, Yutaka, Fukushima, Mitsuo, Seino, Susumu·2015·Current Diabetes Reports
DOI 10.1007/s11892-015-0602-9PMC PMC4420838
Open this paper in CoChat — free accountOpen PDF

Abstract

Type 2 diabetes (T2DM) is one of the most serious global health problems and is mainly a result of the drastic increase in East Asia, which includes over a fourth of the global diabetes population. Lifestyle factors and ethnicity are two determinants in the etiology of T2DM, and lifestyle changes such as higher fat intake and less physical activity link readily to T2DM in East Asians. It is widely recognized that T2DM in East Asians is characterized primarily by β cell dysfunction, which is evident immediately after ingestion of glucose or meal, and less adiposity compared to the disease in Caucasians. These pathophysiological differences have an important impact on therapeutic approaches. Here, we revisit the pathogenesis of T2DM in light of β cell dysfunction versus insulin resistance in East Asians and discuss ethnic differences in the contributions of insulin secretion and insulin resistance, together with incretin secretin and action, to glucose intolerance.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s11892-015-0602-9

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 90

  1. [1]IDF Diabetes Atlas 2014 Update Sixth Edition. Brussels: International Diabetes Federation; 2014.
  2. [3]Chan JC Malik V Jia W Kadowaki T Yajnik CS Diabetes in Asia: epidemiology, risk factors, and pathophysiology JAMA 2009 301 2129 2140 10.1001/jama.2009.726 19470990 · DOI · Paper page
  3. [4]Abate N Chandalia M The impact of ethnicity on type 2 diabetes J Diabet Complicat 2003 17 39 58 10.1016/S1056-8727(02)00190-3 12505756 · DOI
  4. [6]Nakanishi S Okubo M Yoneda M Jitsuiki K Yamane K A comparison between Japanese-Americans living in Hawaii and Los Angeles and native Japanese: the impact of lifestyle westernization on diabetes mellitus Biomed Pharmacother 2004 58 571 577 10.1016/j.biopha.2004.10.001 15589065 · DOI
  5. Fujimoto WY Boyko EJ Hayashi T Kahn SE Leonetti DL Risk factors for type 2 diabetes: lessons learned from Japanese Americans in Seattle J Diabetes Investig 2012 3 212 224 10.1111/j.2040-1124.2012.00195.x 22798980 PMC3393109 · DOI
  6. Moller JB Dalla Man C Overgaard RV Ingwersen SH Tornoe CW Ethnic differences in insulin sensitivity, beta-cell function, and hepatic extraction between Japanese and Caucasians: a minimal model analysis J Clin Endocrinol Metab 2014 99 4273 4280 10.1210/jc.2014-1724 25119313 · DOI
  7. Moller JB Pedersen M Tanaka H Ohsugi M Overgaard RV Body composition is the main determinant for the difference in type 2 diabetes pathophysiology between Japanese and Caucasians Diabetes Care 2014 37 796 804 10.2337/dc13-0598 24130359 · DOI
  8. [10]Fukushima M Suzuki H Seino Y Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes Diabetes Res Clin Pract 2004 66S S37 S44 10.1016/j.diabres.2003.11.024 15563978 · DOI
  9. [11]Sloan R Ethnic distribution of diabetes mellitus in Hawaii JAMA 1963 183 419 424 10.1001/jama.1963.03700060061008 13989245 · DOI
  10. [12]Kagan A Harris BR Winkelstein W Jr Johnson KG Kato H Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics J Chron Dis 1974 27 345 364 10.1016/0021-9681(74)90014-9 4436426 · DOI
  11. [13]West KM Diabetes in American Indians and other native populations of the New World Diabetes 1974 23 841 855 10.2337/diab.23.10.841 4213890 · DOI
  12. [14]Olefsky JM LIlly lecture 1980. Insulin resistance and insulin action. An in vitro and in vivo perspective Diabetes 1981 30 148 162 10.2337/diab.30.2.148 7009267 · DOI
  13. [15]McNeely MJ Boyko EJ Type 2 diabetes prevalence in Asian Americans: results of a national health survey Diabetes Care 2004 27 66 69 10.2337/diacare.27.1.66 14693968 · DOI
  14. [16]Fujimoto WY Hershon K Kinyoun J Stolov W Weinberg C Type II diabetes mellitus in Seattle and Tokyo Tohoku J Exp Med 1983 141 Suppl 133 139 10.1620/tjem.141.Suppl_133 6680481 · DOI
  15. [17]Lyssenko V Almgren P Anevski D Perfekt R Lahti K Predictors of and longitudinal changes in insulin sensitivity and secretion preceding onset of type 2 diabetes Diabetes 2005 54 166 174 10.2337/diabetes.54.1.166 15616025 · DOI
  16. [18]Ogihara T Mirmira RG An islet in distress: beta cell failure in type 2 diabetes J Diabetes Investig 2010 1 123 133 24843420 PMC4008003
  17. [20]Fukushima M Usami M Ikeda M Nakai Y Taniguchi A Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes Metabolism 2004 53 831 835 10.1016/j.metabol.2004.02.012 15254872 · DOI
  18. [21]Kadowaki T Miyake Y Hagura R Akanuma Y Kajinuma H Risk factors for worsening to diabetes in subjects with impaired glucose tolerance Diabetologia 1984 26 44 49 10.1007/BF00252262 6368299 · DOI
  19. [22]Iwahashi H Okauchi Y Ryo M Noguchi M Morita S Insulin-secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese patients J Diabetes Investig 2012 3 271 275 10.1111/j.2040-1124.2011.00180.x 24843576 PMC4014949 · DOI
  20. [23]Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, et al. Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients. J Diabet Complicat. 2015;29(3):413–21. 25613093
  21. [24]Seino Y Taminato T Goto Y Ikeda M Imura H Comparative insulinogenic effect of glucose, arginine and glucagon in patients with diabetes mellitus, endocrine disorders and liver disease Acta Diabetol 1975 12 2 89 99 10.1007/BF02624728 769464 · DOI
  22. [25]Kosaka K Kuzuya T Akanuma Y Hagura R Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment Diabetologia 1980 18 23 28 10.1007/BF01228297 6988263 · DOI
  23. [26]Seino Y Goto Y Kurahachi H Sakurai H Ikeda M Alteration of plasma glucagon response to arginine after treatment in patients with diabetes mellitus, Cushing’s syndrome and hypothyroidism Horm Metab Res 1977 9 28 32 10.1055/s-0028-1093578 844789 · DOI
  24. [27]Seino Y Ikeda M Kurahachi H Taminato T Sakurai H Failure of suppress plasma glucagon concentrations by orally administered glucose in diabetic patients after treatment Diabetes 1978 27 1145 1150 10.2337/diab.27.12.1145 363490 · DOI
  25. [28]Tripathy D Carlsson M Almgren P Isomaa B Taskinen MR Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study Diabetes 2000 49 975 980 10.2337/diabetes.49.6.975 10866050 · DOI
  26. [29]Kim DJ Lee MS Kim KW Lee MK Insulin secretory dysfunction and insulin resistance in the pathogenesis of Korean type 2 diabetes mellitus Metabolism 2001 50 590 593 10.1053/meta.2001.22558 11319722 · DOI
  27. [30]Choi YH Ahn YB Yoon KH Kang MI Cha BY New ADA criteria in the Korean population: fasting blood glucose is not enough for diagnosis of mild diabetes especially in the elderly Korean J Intern Med 2000 15 211 217 10.3346/jkms.2000.15.2.211 11242809 PMC4531770 · DOI
  28. [31]Qian L Xu L Wang X Fu X Gu Y Early insulin secretion failure leads to diabetes in Chinese subjects with impaired glucose regulation Diabetes Metab Res Rev 2009 25 144 149 10.1002/dmrr.922 19116942 · DOI
  29. [32]Pang C Bao YQ Wang C Lu JX Jia WP Relationship between the level of fasting plasma glucose and beta cell functions in Chinese with or without diabetes Chin Med J (Engl) 2008 121 2119 2123 19080169
  30. [33]Taniguchi A Nakai Y Fukushima M Kawamura H Imura H Pathogenic factors responsible for glucose intolerance in patients with NIDDM Diabetes 1992 41 1540 1546 10.2337/diab.41.12.1540 1446794 · DOI
  31. [34]Welch S Gebhart SS Bergman RN Phillips LS Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects J Clin Endocrinol Metab 1990 71 1508 1518 10.1210/jcem-71-6-1508 2229309 · DOI
  32. [36]Tanaka S Horimai C Katsukawa F Ethnic differences in abdominal visceral fat accumulation between Japanese, African-Americans, and Caucasians: a meta-analysis Acta Diabetol 2003 40 Suppl 1 S302 S304 10.1007/s00592-003-0093-z 14618500 · DOI
  33. [37]DECODE Study Group on behalf of the European Diabetes Epidemiology Study Group. Will new diagnostic criteria for diabetes mellitus change phenotype of patients with diabetes? Reanalysis of European epidemiological data. BMJ 1998;317:371–75. PMC28629 9694750
  34. [38]Qiao Q Nakagami T Tuomilehto J Borch-Johnsen K Balkau B Comparison of the fasting and the 2-h glucose criteria for diabetes in different Asian cohorts Diabetologia 2000 43 1470 1475 10.1007/s001250051557 11151755 · DOI
  35. [39]Suzuki H Fukushima M Usami M Ikeda M Taniguchi A Factors responsible for development from normal glucose tolerance to isolated postchallenge hyperglycemia Diabetes Care 2003 26 1211 1215 10.2337/diacare.26.4.1211 12663599 · DOI
  36. [40]Mitsui R Fukushima M Taniguchi A Nakai Y Aoyama S Insulin secretory capacity and insulin sensitivity in impaired fasting glucose in Japanese J Diabetes Investig 2012 3 377 383 10.1111/j.2040-1124.2012.00201.x 24843593 PMC4019258 · DOI
  37. [41]Nishi Y Fukushima M Suzuki H Mitsui R Ueda N Insulin secretion and insulin sensitivity in Japanese subjects with impaired fasting glucose and isolated fasting hyperglycemia Diabetes Res Clin Pract 2005 70 46 52 10.1016/j.diabres.2005.02.015 16126123 · DOI
  38. [42]Nakagami T Qiao Q Carstensen B Nhr-Hansen C Hu G Age, body mass index and type 2 diabetes-associations modified by ethnicity Diabetologia 2003 46 1063 1070 10.1007/s00125-003-1158-9 12827246 · DOI · Paper page
  39. [43]Fujimoto WY Leonetti DL Kinyoun JL Shuman WP Stolov WC Prevalence of complications among second-generation Japanese-American men with diabetes, impaired glucose tolerance, or normal glucose tolerance Diabetes 1987 36 730 739 10.2337/diab.36.6.730 3569672 · DOI
  40. [44]Fujimoto WY Leonetti DL Kinyoun JL Newell-Morris L Shuman WP Prevalence of diabetes mellitus and impaired glucose tolerance among second-generation Japanese-American men Diabetes 1987 36 721 729 10.2337/diab.36.6.721 3569671 · DOI
  41. [45]Matsubara T Mita A Minami K Hosooka T Kitazawa S PGRN is a key adipokine mediating high fat diet-induced insulin resistance and obesity through IL-6 in adipose tissue Cell Metab 2012 15 38 50 10.1016/j.cmet.2011.12.002 22225875 · DOI
  42. [46]Yasuda K Miyake K Horikawa Y Hara K Osawa H Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus Nat Genet 2008 40 1092 1097 10.1038/ng.207 18711367 · DOI · Paper page
  43. [47]Unoki H Takahashi A Kawaguchi T Hara K Horikoshi M SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations Nat Genet 2008 40 1098 1102 10.1038/ng.208 18711366 · DOI · Paper page
  44. [48]Ullrich S Su J Ranta F Wittekindt OH Ris F Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells Pflugers Arch 2005 451 428 436 10.1007/s00424-005-1479-2 16133261 · DOI
  45. [49]Yamauchi T Hara K Maeda S Yasuda K Takahashi A A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B Nat Genet 2010 42 864 868 10.1038/ng.660 20818381 · DOI
  46. [50]Kimura M Hattori T Matsuda Y Yoshioka T Sumi N cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme Cytogenet Cell Genet 1997 78 107 111 10.1159/000134639 9371400 · DOI
  47. [51]Tsai FJ Yang CF Chen CC Chuang LM Lu CH A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese PLoS Genet 2010 6 e1000847 10.1371/journal.pgen.1000847 20174558 PMC2824763 · DOI
  48. [52]Shu XO Long J Cai Q Qi L Xiang YB Identification of new genetic risk variants for type 2 diabetes PLoS Genet 2010 6 e1001127 10.1371/journal.pgen.1001127 20862305 PMC2940731 · DOI
  49. [53]Wolosker H Blackshaw S Snyder SH Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission Proc Natl Acad Sci U S A 1999 96 13409 13414 10.1073/pnas.96.23.13409 10557334 PMC23961 · DOI · Paper page
  50. [54]Gonoi T Mizuno N Inagaki N Kuromi H Seino Y Functional neuronal ionotropic glutamate receptors are expressed in the non-neuronal cell line MIN6 J Biol Chem 1994 269 16989 16992 8006003
  51. [55]Cho YS Chen CH Hu C Long J Ong RT Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in East Asians Nat Genet 2012 44 67 72 10.1038/ng.1019 22158537 PMC3582398 · DOI
  52. [56]Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, et al. Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes. 2015;64(1):291–8. PMC4274808 25187374
  53. [57]Neel JV Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 1962 14 353 362 13937884 PMC1932342
  54. [59]Cho YS Lee JY Park KS Nho CW Genetics of type 2 diabetes in East Asian populations Curr Diabetes Rep 2012 12 686 696 10.1007/s11892-012-0326-z 22993124 · DOI
  55. [60]Nauck MA Homberger E Siegel EG Allen RC Eaton RP Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses J Clin Endocrinol Metab 1986 63 492 498 10.1210/jcem-63-2-492 3522621 · DOI · Paper page
  56. [61]Knop FK Vilsboll T Hojberg PV Larsen S Madsbad S Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state? Diabetes 2007 56 1951 1959 10.2337/db07-0100 17513701 · DOI · Paper page
  57. [63]Seino Y Fukushima M Yabe D GIP and GLP-1, the two incretin hormones: similarities and differences J Diabetes Investig 2010 1 9 23 PMC4020673 24843404
  58. [64]Yabe D Seino Y Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and beta cell preservation Prog Biophys Mol Biol 2011 107 248 256 10.1016/j.pbiomolbio.2011.07.010 21820006 · DOI
  59. [65]Holst JJ The physiology of glucagon-like peptide 1 Physiol Rev 2007 87 1409 1439 10.1152/physrev.00034.2006 17928588 · DOI · Paper page
  60. [67]Seino Y Yabe D GIP and GLP-1: incretin actions beyond pancreas J Diabetes Investig 2013 4 108 130 10.1111/jdi.12065 24843641 PMC4019264 · DOI
  61. Calanna S Christensen M Holst JJ Laferrere B Gluud LL Secretion of glucagon-like peptide-1 in patients with type 2 diabetes mellitus: systematic review and meta-analyses of clinical studies Diabetologia 2013 56 965 972 10.1007/s00125-013-2841-0 23377698 PMC3687347 · DOI · Paper page
  62. Calanna S Christensen M Holst JJ Laferrere B Gluud LL Secretion of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes: systematic review and meta-analysis of clinical studies Diabetes Care 2013 36 3346 3352 10.2337/dc13-0465 24065842 PMC3781498 · DOI · Paper page
  63. [70]Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia. 2011;54(1):10–8. 20871975
  64. [71]Yabe D Kuroe A Lee S Watanabe K Hyo T Little enhancement of meal-induced GLP-1 secretion in Japanese: comparison of type 2 diabetes and healthy controls J Diabetes Investig 2010 1 56 59 10.1111/j.2040-1124.2010.00010.x 24843409 PMC4020678 · DOI
  65. [72]Kozawa J Okita K Imagawa A Iwahashi H Holst JJ Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes Biochem Biophys Res Commun 2010 393 410 413 10.1016/j.bbrc.2010.01.134 20138827 · DOI
  66. [73]Lee S Yabe D Nohtomi K Takada M Morita R Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes Endocr J 2010 57 119 126 10.1507/endocrj.K09E-269 19881250 · DOI
  67. [74]Oh TJ, Park KS, Cho YM. Correlation of the incretin effect with first- and second-phase insulin secretions in Koreans with various glucose tolerance statuses. Clin Endocrinol (Oxf). 2014. doi:10.1111/cen.12623. 25267549 · DOI
  68. [75]Oh TJ Kim MY Shin JY Lee JC Kim S The incretin effect in Korean subjects with normal glucose tolerance or type 2 diabetes Clin Endocrinol (Oxf) 2014 80 221 227 10.1111/cen.12167 23405851 · DOI
  69. [76]Yabe D Watanabe K Sugawara K Kuwata H Kitamoto Y Comparison of incretin immunoassays with or without plasma extraction: incretin secretion in Japanese patients with type 2 diabetes J Diabetes Investig 2012 3 70 79 10.1111/j.2040-1124.2011.00141.x 24843548 PMC4014935 · DOI
  70. [77]Vollmer K Holst JJ Baller B Ellrichmann M Nauck MA Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance Diabetes 2008 57 678 687 10.2337/db07-1124 18057091 · DOI
  71. [78]Vilsboll T Krarup T Madsbad S Holst JJ Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients Diabetologia 2002 45 1111 1119 10.1007/s00125-002-0878-6 12189441 · DOI · Paper page
  72. [79]Saxena R Hivert MF Langenberg C Tanaka T Pankow JS Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat Genet 2010 42 142 148 10.1038/ng.521 20081857 PMC2922003 · DOI
  73. [81]Gheni G Ogura M Iwasaki M Yokoi N Minami K Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion Cell Rep 2014 9 661 673 10.1016/j.celrep.2014.09.030 25373904 PMC4536302 · DOI · Paper page
  74. [82]Park H Park C Kim Y Rascati KL Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis Ann Pharmacother 2012 46 1453 1469 10.1345/aph.1R041 23136353 · DOI
  75. Kim YG Hahn S Oh TJ Kwak SH Park KS Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and Non-Asians: a systematic review and meta-analysis Diabetologia 2013 56 696 708 10.1007/s00125-012-2827-3 23344728 · DOI
  76. Kim YG, Hahn S, Oh TJ, Park KS, Cho YM. Differences in the HbA1c-lowering efficacy of glucagon-like peptide-1 analogues between Asians and non-Asians: a systematic review and meta-analysis. Diabetes Obes Metab. 2014;16(10):900–9.An important systematic review and meta-analysis comparing glucose-lowering effects of glucagon-like peptide-1 between Asians and non-Asians. 24655583
  77. [85]Kubota A Matsuba I Saito T Nabe K Seino Y Secretory units of islets in transplantation index is a useful clinical marker to evaluate the efficacy of sitagliptin in treatment of type 2 diabetes mellitus J Diabetes Investig 2011 2 377 380 10.1111/j.2040-1124.2011.00109.x 24843517 PMC4019306 · DOI
  78. [86]Seino Y Rasmussen MF Clauson P Kaku K The once-daily human glucagon-like peptide-1 analog, liraglutide, improves β-cell function in Japanese patients with type 2 diabetes J Diabetes Investig 2012 3 388 395 10.1111/j.2040-1124.2012.00193.x 24843595 PMC4019260 · DOI
  79. Iwasaki M Hoshian F Tsuji T Hirose N Matsumoto T Predicting efficacy of DPP-4 inhibitors in patients with type 2 diabetes: association of HbA1c reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels J Diabetes Investig 2012 3 464 467 10.1111/j.2040-1124.2012.00214.x 24843607 PMC4019247 · DOI
  80. [88]Senmaru T Fukui M Kobayashi K Iwase H Inada S Dipeptidyl-peptidase IV inhibitor is effective in patients with type 2 diabetes with high serum eicosapentaenoic acid concentrations J Diabetes Investig 2012 3 498 502 10.1111/j.2040-1124.2012.00220.x 24843614 PMC4015428 · DOI
  81. [90]Kubota A Yabe D Kanamori A Kuroe A Takahashi N Factors influencing the durability of the glucose-lowering effect of sitagliptin combined with a sulfonylurea J Diabetes Investig 2014 5 445 448 10.1111/jdi.12182 25411605 PMC4210074 · DOI
  82. [91]Kanamori A Matsuba I Factors associated with reduced efficacy of sitagliptin therapy: analysis of 93 patients with type 2 diabetes treated for 1.5 years or longer J Clin Med Res 2013 5 217 221 23671547 PMC3651072
  83. [92]Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, et al. Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: comparison of DPP-4 inhibitors with other oral antidiabetic drugs. Diabetes Obes Metab. 2015;17(4):430–34. PMC4409841 25146418
  84. [93]Kohro T Yamazaki T Sato H Harada K Ohe K Trends in antidiabetic prescription patterns in Japan from 2005 to 2011 Int Heart J 2013 54 93 97 10.1536/ihj.54.93 23676369 · DOI
  85. [95]Inzucchi SE Bergenstal RM Buse JB Diamant M Ferrannini E Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) Diabetes Care 2012 35 1364 1379 10.2337/dc12-0413 22517736 PMC3357214 · DOI · Paper page
  86. Yabe D Seino Y Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: friend or foe? J Diabetes Investig 2014 5 475 477 10.1111/jdi.12229 25411611 PMC4188101 · DOI
  87. [97]Takahashi H, Shibasaki T, Park JH, Hidaka S, Takahashi T, et al. Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion. Diabetes. 2015;64(4):1262–72. 25315008
  88. [98]Shibasaki T Takahashi T Takahashi H Seino S Cooperation between cAMP signalling and sulfonylurea in insulin secretion Diabetes Obes Metab 2014 16 Suppl 1 118 125 10.1111/dom.12343 25200305 · DOI
  89. [99]Takahashi T Shibasaki T Takahashi H Sugawara K Ono A Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A Sci Signal 2013 6 ra94 24150255
  90. [100]Mukai E Fujimoto S Sato H Oneyama C Kominato R Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner Diabetes 2010 60 218 226 10.2337/db10-0021 20978090 PMC3012174 · DOI

Cited by

Sorted by citations

Authors
Yabe, D., Seino, Y., Fukushima, M., & Seino, S.
Affiliations
  • Kansai Electric Power (Japan) (JP)
  • Okayama Prefectural University (JP)
  • Kobe University (JP)
Corresponding author
Yabe, Daisuke
ORCID
Venue
Current Diabetes Reports
Publisher
Springer Science and Business Media LLC
Published
2015-05-06
Volume
15
Issue
6
Pages
602-602
ISSN
  • 1534-4827 (ISSN-L)
  • 1539-0829
DOI
10.1007/s11892-015-0602-9
PMC
PMC4420838
OpenAlex
W1944521216
Cited by
328
References
8
Citations by year
2026: 26 · 2025: 39 · 2024: 31 · 2023: 20 · 2022: 45 · 2021: 32 · 2020: 29 · 2019: 18 · 2018: 33 · 2017: 25 · 2016: 19 · 2015: 11
FWCI
29.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Diabetes Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (24229007, 25860748)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, beta-cell dysfunction, insulin resistance, East Asians, ethnic differences, insulin secretion, incretins, impaired glucose tolerance, pathogenesis, lifestyle factors, adiposity
MeSH terms
Insulin Secretion, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Asian People, Insulin-Secreting Cells, Incretins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review