The DOI matches its Crossref record; 218 of the 219 references it cites were found in a registry or an index.
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Abstract
Purpose of review The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies.Recent findings Work on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges. Animal and translational models have incriminated a disturbed gut microbiota in a number of CNS disorders, including Parkinson's disease; data from human studies is scanty. While a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders, support is yet to come from high-quality clinical trials. In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited.
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“Increasing evidence suggests there is bidirectional communication between the gut and the brain [6–8].”
From Neuroprotective Effect of Ceftriaxone on MPTP‐Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota (2021) · cites this paper as [7]
In the citing paper
“The gut microbiota, a diverse community of microorganisms inhabiting the gastrointestinal tract, begins to develop in the prenatal period, and disruptions in its composition during the first 2–3 years of life can negatively impact development and increase the risk of future diseases [15].”
From The Gut–Brain–Microbiota Connection and Its Role in Autism Spectrum Disorders (2025) · cites this paper as [15]
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Cites
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1 of the 219 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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The Controversial Role of Human Gut Lachnospiraceae
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Metadata
- Authors
- Quigley, E. M. M.
- Affiliations
- Houston Methodist (US)
- Corresponding author
- Quigley, Eamonn M. M.
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2017-10-17
- Volume
- 17
- Issue
- 12
- Pages
- 94-94
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2766853085
- Cited by
- 804
- References
- 219
- Citations by year
- 2026: 46 · 2025: 86 · 2024: 111 · 2023: 150 · 2022: 126 · 2021: 130 · 2020: 80 · 2019: 46 · 2018: 29
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- microbiota-gut-brain axis, gut microbiota, neurodegenerative diseases, Parkinson's disease, microbiota-targeted therapy, central nervous system disorders, animal models of neurodegeneration, translational model
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Humans, Neurodegenerative Diseases, Molecular Targeted Therapy
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