Cited by 849Gut microbiota and healthParkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, Eamonn M. M.·2017·Current Neurology and Neuroscience Reports

DOI 10.1007/s11910-017-0802-6

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Abstract

Purpose of review The purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies.Recent findings Work on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges. Animal and translational models have incriminated a disturbed gut microbiota in a number of CNS disorders, including Parkinson's disease; data from human studies is scanty. While a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders, support is yet to come from high-quality clinical trials. In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited.

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Authors: Quigley, E. M. M.
Affiliations: Houston Methodist (US)
Corresponding author: Quigley, Eamonn M. M.
ORCID: Quigley, Eamonn M. M.
Venue: Current Neurology and Neuroscience Reports
Publisher: Springer Science and Business Media LLC
Published: 2017-10-17
Volume: 17
Issue: 12
Pages: 94-94
ISSN: 1528-4042 (ISSN-L)
1534-6293
DOI: 10.1007/s11910-017-0802-6
OpenAlex: W2766853085
Cited by: 804
References: 219
Citations by year: 2026: 46 · 2025: 86 · 2024: 111 · 2023: 150 · 2022: 126 · 2021: 130 · 2020: 80 · 2019: 46 · 2018: 29
FWCI: 4.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Current Neurology and Neuroscience Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: microbiota-gut-brain axis, gut microbiota, neurodegenerative diseases, Parkinson's disease, microbiota-targeted therapy, central nervous system disorders, animal models of neurodegeneration, translational model
MeSH terms: Gastrointestinal Microbiome, Animals, Brain, Humans, Neurodegenerative Diseases, Molecular Targeted Therapy

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