HIF Inhibitors: Status of Current Clinical Development

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation

Noman, M. Z., Desantis, G., Janji, B., Hasmim, M., Karray, S., Dessen, P., Bronte, V., & Chouaib, S. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20131916 · Cited by 2,166

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,166

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990

Hypoxia-Inducible Factor 1 (HIF-1) Pathway

Semenza, G. L. (2007) · Science s STKE · doi:10.1126/stke.4072007cm8 · Cited by 970

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma

Raval, R. R., Lau, K. W., Tran, M. G. B., Sowter, H. M., Mandriota, S. J., Li, J.-L., Pugh, C. W., Maxwell, P. H., Harris, A. L., & Ratcliffe, P. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5675-5686.2005 · Cited by 940

Phase I Study of an Oral Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid, in Patients With Advanced Cancer

Kelly, W. K., O’Connor, O. A., Krug, L. M., Chiao, J. H., Heaney, M. L., Curley, T., MacGregor‐Cortelli, B., Tong, W. P., Secrist, J. P., Schwartz, L. B., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.14.167 · Cited by 906

Regulation of the HIF switch in human endothelial and cancer cells

Slawski, J., Jaśkiewicz, M., Barton, A., Kozioł, S., Collawn, J. F., & Bartoszewski, R. (2024) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2024.151386 · Cited by 26

The β3 adrenoceptor in proliferative retinopathies: “Cinderella” steps out of its family shadow

Cammalleri, M., Amato, R., Monte, M. D., Filippi, L., & Bagnoli, P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106713 · Cited by 30

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

Chelakkot, V. S., Liu, K., Yoshioka, E., Saha, S., Xu, D., Licursi, M., Dorward, A. M., & Hirasawa, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-79144-x · Cited by 26

Engineering Metabolism of Chimeric Antigen Receptor (CAR) Cells for Developing Efficient Immunotherapies

Mangal, J. L., Handlos, J. L., Esrafili, A., Inamdar, S., Mcmillian, S., Wankhede, M., Gottardi, R., & Acharya, A. P. (2021) · Cancers · doi:10.3390/cancers13051123 · Cited by 26

PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma

Phillips, E. S., Balß, J., Bethke, F., Pusch, S., Christen, S., Hielscher, T., Schnölzer, M., Fletcher, M. N. C., Habel, A., Tessmer, C., et al. (2022) · Oncogenesis · doi:10.1038/s41389-022-00433-3 · Cited by 26

Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis

Wang, X., Song, J., Yuan, Y., Li, L., Abu-Taha, I., Heijman, J., Sun, L. T., Dobrev, S., Kamler, M., Xie, L., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322213 · Cited by 31

Cellular adaptation to oxygen deficiency beyond the Nobel award

López‐Barneo, J., & Simon, M. C. (2020) · Nature Communications · doi:10.1038/s41467-020-14469-9 · Cited by 26

The Role of Metabolic Plasticity in Blood and Brain Stem Cell Pathophysiology

Libby, C. J., McConathy, J., Darley-Usmar, V. M., & Hjelmeland, A. B. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1169 · Cited by 25

Discoveries of how cells sense oxygen win the 2019 Nobel Prize in Physiology or medicine

Lee, C., Wu, C., & Yang, H. (2020) · Biomedical Journal · doi:10.1016/j.bj.2020.05.019 · Cited by 26

Oxygen Sensing and Viral Replication: Implications for Tropism and Pathogenesis

Liu, P. J., Balfe, P., McKeating, J. A., & Schilling, M. (2020) · Viruses · doi:10.3390/v12111213 · Cited by 23

Hypoxia inducible factor signaling in breast tumors controls spontaneous tumor dissemination in a site-specific manner

Todd, V. M., Vecchi, L. A., Clements, M. E., Snow, K. P., Ontko, C. D., Himmel, L. E., Pinelli, C. J., Rafat, M., & Johnson, R. W. (2021) · Communications Biology · doi:10.1038/s42003-021-02648-3 · Cited by 26

HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease

Little, A. J., Chen, P.-M., Vesely, M. D., Khan, R. N., Fiedler, J., Garritano, J., Maisha, F. I., McNiff, J. M., & Craft, J. E. (2023) · JCI Insight · doi:10.1172/jci.insight.166076 · Cited by 27

HIF-1α-Mediated Disruption of Cellular Junctions: The Impact of Hypoxia on the Tumor Microenvironment and Invasion

Domukhovska, A., Burakgazi, Z. A., Springer, M., Nafchi, B., Beary, M. C., Acquisto, A., Acquisto, J., Komarov, V., Jensen, M., Gulledge, B., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115101 · Cited by 26

PX478-loaded silk fibroin nanoparticles reverse multidrug resistance by inhibiting the hypoxia-inducible factor

Li, Z., Cheng, G., Zhang, Q., Wu, W., Zhang, Y., Wu, B., Liu, Z., Tong, X., Xiao, B., Cheng, L., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.018 · Cited by 24

Physiological and Pathological Remodeling of Cerebral Microvessels

Tregub, P. P., Сергеевич, А. А., Baranich, T. I., Ryazanova, M. V., & Salmina, A. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012683 · Cited by 25

The pathogenesis and regulatory role of HIF-1 in rheumatoid arthritis

Li, H., Wu, Q.-Y., Teng, X.-H., Li, Z.-P., Zhu, M., Gu, C.-J., Chen, B.-J., Xie, Q.-Q., & Luo, X.-J. (2024) · Central European Journal of Immunology · doi:10.5114/ceji.2023.134217 · Cited by 26

Suppression of HIF-1α accumulation by betulinic acid through proteasome activation in hypoxic cervical cancer

Kim, H.-J., Cho, H., Ban, H. S., & Nakamura, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.01.031 · Cited by 23

Analyses of the 2019 Nobel Prize in Physiology or Medicine: Molecular Machinery for Cellular Oxygen Level Response

Gilman, N. (2020) · Science & Technology Libraries · doi:10.1080/0194262x.2019.1703875 · Cited by 22

Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells

Zichittella, C., Barreca, M. M., Cordaro, A., Corrado, C., Alessandro, R., & Conigliaro, A. (2022) · BMC Cancer · doi:10.1186/s12885-022-09666-2 · Cited by 22

Inhibition of Hypoxia-Inducible Transcription Factor (HIF-1α) Signaling with Sulfonyl-γ-AApeptide Helices

Jiang, W., Abdulkadir, S., Zhao, X., Sang, P., Τοματσίδου, Α., Zhang, X., Chen, Y., Calcul, L., Sun, X., Cheng, F., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c06694 · Cited by 24

Computational Prediction of Antiangiogenesis Synergistic Mechanisms of Total Saponins of Panax japonicus Against Rheumatoid Arthritis

Guo, X., Ji, J., Sreena, G. S. J. K., Hou, X., Luo, Y., Fu, X., Mei, Z., & Feng, Z. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.566129 · Cited by 21

Anti-hypoxia nanosized drug delivery systems improving cancer therapy

Yan, W., Lang, T., Zhu, R., Zhu, X. G., Yu, H., Wu, T., Yin, Q., & Li, Y. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101376 · Cited by 21

Network pharmacology and metabolomics elucidate the underlying mechanisms of Venenum Bufonis in the treatment of colorectal cancer

Tao, C., Wang, J., Gu, Z., Ni, H., Luo, Y., Ling, J., Chen, Y., Wu, Y., Liu, X., Zhou, Y., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116695 · Cited by 21

The journey from erythropoietin to 2019 Nobel Prize: Focus on hypoxia-inducible factors in the kidney

Pan, S., Chiang, W., & Chen, Y. (2020) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2020.06.006 · Cited by 24

Role of hyperoxic treatment in cancer

Kim, S. W., Kim, I. K., & Lee, S. H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220921547 · Cited by 20

Myelodysplastic Syndromes and Metabolism

Balaian, E., Wobus, M., Bornhäuser, M., Chavakis, T., & Sockel, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011250 · Cited by 23

Cancer-specific cytotoxicity of pyridinium-based ionic liquids by regulating hypoxia-inducible factor-1α-centric cancer metabolism

Han, T.-H., Lee, J., Seo, B.-C., Jeon, W.-H., Yang, H.-A., Kim, S., Haam, K., Park, M. K., Park, J., Han, T., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114334 · Cited by 21

Total Synthesis of (+)‐Discorhabdin V**

Derstine, B. C., Cook, A. J., Collings, J. D., Gair, J. J., Saurí, J., Kwan, E. E., & Burns, N. Z. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202315284 · Cited by 20

PX-478, an HIF-1α inhibitor, impairs mesoCAR T cell antitumor function in cervical cancer

Meymandi, A. R. P., Akbari, B., Soltantoyeh, T., Shahosseini, Z., Hosseini, M., Hadjati, J., & Mirzaei, H. R. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1357801 · Cited by 21

The Roles of Hypoxia-Inducible Factors and Non-Coding RNAs in Gastrointestinal Cancer

Cho, H., Han, T., Hur, K., & Ban, H. S. (2019) · Genes · doi:10.3390/genes10121008 · Cited by 20

TGF-β protects osteosarcoma cells from chemotherapeutic cytotoxicity in a SDH/HIF1α dependent manner

Xu, Y., Li, Y., Chen, X., Xiang, F., Deng, Y., Zhong, L., & Wei, D. (2021) · BMC Cancer · doi:10.1186/s12885-021-08954-7 · Cited by 20

Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α

Ortega‐Sáenz, P., Moreno‐Domínguez, A., Gao, L., & López‐Barneo, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.614893 · Cited by 21

Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum

Evans, H. M., Schultz, D. F., Boiman, A. J., McKell, M. C., Qualls, J. E., & Deepe, G. S. (2021) · mBio · doi:10.1128/mbio.02710-21 · Cited by 19

Downregulation of both mismatch repair and non-homologous end-joining pathways in hypoxic brain tumour cell lines

Cowman, S. J., Pizer, B. L., & Sée, V. (2021) · PeerJ · doi:10.7717/peerj.11275 · Cited by 19

Obesity, dysbiosis and inflammation: interactions that modulate the efficacy of immunotherapy

Yende, A. S., & Sharma, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1444589 · Cited by 19

Can Targeting Hypoxia-Mediated Acidification of the Bone Marrow Microenvironment Kill Myeloma Tumor Cells?

Gastelum, G., Veena, M. S., Lyons, K., Lamb, C. J., Jacobs, N. M., Yamada, A., Baibussinov, A., Sarafyan, M., Shamis, R., Kraut, J., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.703878 · Cited by 18

Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology

Chen, S., Jiang, J., Shen, A., Miao, Y., Cao, Y., Zhang, Y., Cong, P., & Gao, P. (2022) · Metabolites · doi:10.3390/metabo12100918 · Cited by 17

VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α

Yue, Y., Tang, Y., Huang, H., Zheng, D., Liu, C., Zhang, H., Liu, Y., Li, Y., Sun, X., & Lu, L. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104829 · Cited by 18

Identifying Hypoxia Characteristics to Stratify Prognosis and Assess the Tumor Immune Microenvironment in Renal Cell Carcinoma

Zhang, Z., Li, Q., Wang, F., Ma, B., Meng, Y., & Zhang, Q. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.606816 · Cited by 17

Targeting Hypoxia: Revival of Old Remedies

Vilaplana‐Lopera, N., Besh, M., & Moon, E. J. (2021) · Biomolecules · doi:10.3390/biom11111604 · Cited by 17

Belzutifan: A Narrative Drug Review

Visweswaran, V., & Pavithran, K. (2022) · Current Drug Research Reviews · doi:10.2174/2589977514666220401094724 · Cited by 17

Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast Cancer

Jehanno, C., Goff, P. L., Habauzit, D., Page, Y. L., Lecomte, S., Lecluze, E., Percevault, F., Avner, S., Métivier, R., Michel, D., et al. (2022) · Cancers · doi:10.3390/cancers14194934 · Cited by 16

Discovery of novel direct small-molecule inhibitors targeting HIF-2α using structure-based virtual screening, molecular dynamics simulation, and MM-GBSA calculations

Yazdani, B., Sirous, H., Enguita, F. J., Brogi, S., Wing, P. A. C., & Fassihi, A. (2023) · Molecular Diversity · doi:10.1007/s11030-023-10650-6 · Cited by 16

The disubstituted adamantyl derivative LW1564 inhibits the growth of cancer cells by targeting mitochondrial respiration and reducing hypoxia-inducible factor (HIF)-1α accumulation

Kim, I., Kim, M., Park, M. K., Naik, R., Park, J. H., Kim, B., Choi, Y., Chang, K. Y., Won, M., Ban, H. S., et al. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00523-5 · Cited by 16

HIF in Nephrotoxicity during Cisplatin Chemotherapy: Regulation, Function and Therapeutic Potential

Li, S., Wen, L., Hu, X., Wei, Q., & Dong, Z. (2021) · Cancers · doi:10.3390/cancers13020180 · Cited by 17

Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies

Polania, J. W., Lerner, E., Wilkinson, D. S., Hoyt-Miggelbrink, A. M., & Fecci, P. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.777073 · Cited by 17

Personalized Systemic Therapies in Hereditary Cancer Syndromes

Mastrodomenico, L., Piombino, C., Riccò, B., Barbieri, E., Venturelli, M., Piacentini, F., Dominici, M., Cortesi, L., & Toss, A. (2023) · Genes · doi:10.3390/genes14030684 · Cited by 17

Clinical significance and in vitro cellular regulation of hypoxia mimicry on HIF-1α and downstream genes in canine appendicular osteosarcoma

Gola, C., Iussich, S., Noury, S., Martano, M., Gattino, F., Morello, E. M., Martignani, E., Maniscalco, L., Accornero, P., Buracco, P., et al. (2020) · The Veterinary Journal · doi:10.1016/j.tvjl.2020.105538 · Cited by 16

Turning Fluvastatin into a supramolecular immuno-sensitizer towards augmented tumor immunotherapy

Ma, F., Liu, T., Yang, W., You, W., He, W., Yan, J., & Liu, W. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.135310 · Cited by 15

Novel Hypoxia-Related Gene Signature for Risk Stratification and Prognosis in Hepatocellular Carcinoma

Li, Q., Jin, L., & Jin, M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.613890 · Cited by 15

Conducive target range of breast cancer: Hypoxic tumor microenvironment

Cheng, W., Xiao, X., Liao, Y., Cao, Q., Wang, C., Li, X., & Jia, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.978276 · Cited by 14

Glycolysis modulation: New therapeutic strategies to improve pulmonary hypertension (Review)

Chen, M., Li, H., Li, Y., Luo, Y., He, Y. Z., Shui, X., & Lei, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5439 · Cited by 15

Therapeutic sequencing in advanced renal cell carcinoma: How to choose considering clinical and biological factors

Delcuratolo, M. D., Tucci, M., Turco, F., Stefano, R. F. D., Ungaro, A., Audisio, M., Samuelly, A., Brusa, F., Audisio, A., Maïo, M. D., et al. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103881 · Cited by 13

Associations between HIFs and tumor immune checkpoints: mechanism and therapy

Liu, J., Jiang, Y., Chen, L., Qian, Z., & Zhang, Y. (2024) · Discover Oncology · doi:10.1007/s12672-023-00836-7 · Cited by 13

Carotid Body Function in Tyrosine Hydroxylase Conditional Olfr78 Knockout Mice

Colinas, O., Mombaerts, P., López‐Barneo, J., & Ortega‐Sáenz, P. (2024) · Function · doi:10.1093/function/zqae010 · Cited by 14

Advancements in understanding the molecular mechanisms and clinical implications of Von Hippel-Lindau syndrome: A comprehensive review

Wang, Y., Song, J., Zheng, S., & Wang, S. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102193 · Cited by 13

Immunogenomic Profiling and Classification of Prostate Cancer Based on HIF-1 Signaling Pathway

Song, J., Chen, W., Zhu, G., Wang, W., Sun, F., & Zhu, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01374 · Cited by 13

Hypoxia stabilizes SETDB1 to maintain genome stability

Park, S., Cho, J. H., Kim, J.-H., Park, S., (18229615), S. P., Kim, S., Kim, S., Kim, K., Park, B. C., Park, B. C., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad796 · Cited by 11

Hypoxia-Targeted Responsive Delivery of Doxorubicin and Digoxin for Synergistic Treatment of Triple-Negative Breast Cancer

Weng, L., Zhao, M., Chen, Z., & Zhu, L. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c01325 · Cited by 12

Anemia management in cancer patients with chronic kidney disease

Latcha, S. (2019) · Seminars in Dialysis · doi:10.1111/sdi.12841 · Cited by 12

mRNA expression level of CDH2, LEP, POSTN, TIMP1 and VEGFC modulates 5‑fluorouracil resistance in colon cancer cells

Liu, T., Xia, R., Li, C., Chen, X., Cai, X., & Li, W. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10455 · Cited by 12

Gene expression and oxidative stress markers profile associated with toxic metals in patients with renal cell carcinoma

Tarabay, H. H., Abol‐Enein, H., Awadalla, A., Mortada, W. I., & Abdel-Aziz, A. F. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06944-3 · Cited by 12

Phyto-Immunotherapy, a Complementary Therapeutic Option to Decrease Metastasis and Attack Breast Cancer Stem Cells

Susana Fiorentino, G., Urueña, C. P., Lasso, P., Prieto, K., & Barreto, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01334 · Cited by 12

Prolonged hypoxia switched on cancer stem cell-like plasticity in HepG2 tumourspheres cultured in serum-free media

Ayob, A. Z., & Ramasamy, T. S. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-021-00625-y · Cited by 13

Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review

Kong, W., Liao, Y., Zhao, L., Hall, N., Zhou, H., Liu, R., Persson, P. B., & Lai, E. (2023) · Biomedicines · doi:10.3390/biomedicines11112984 · Cited by 11

β-Caryophyllene Inhibits Endothelial Tube Formation by Modulating the Secretome of Hypoxic Lung Cancer Cells—Possible Role of VEGF Downregulation

Wittig, F., Koch, F., Pannenberg, L., Bekeschus, S., Ramer, R., & Hinz, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020810 · Cited by 11

HIF1A/PCDH7 axis mediates fatty acid synthesis and metabolism to inhibit lung adenocarcinoma anoikis

Yang, X., Zhang, Q., Wei, L., & Liu, K. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70001 · Cited by 11

Novel anticancer drug discovery strategies targeting hypoxia-inducible factors

Mustafa, M., Rashed, M., & Winum, J. (2024) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2024.2442739 · Cited by 11

Involvement of hypoxia‐inducible factor activity in inevitable air‐exposure treatment upon differentiation in a three‐dimensional keratinocyte culture

Teshima, H., Endo, M., Furuyama, Y., Takama, H., Akiyama, M., Tsuji, T., Tatsukawa, H., & Hitomi, K. (2022) · FEBS Journal · doi:10.1111/febs.16707 · Cited by 12

Lymphatic Vessel Regression and Its Therapeutic Applications: Learning From Principles of Blood Vessel Regression

Masood, F., Bhattaram, R., Rosenblatt, M. I., Kazlauskas, A., Chang, J., & Azar, D. T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.846936 · Cited by 11

Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia

Caballero‐Eraso, C., Colinas, O., Sobrino, V., González‐Montelongo, R., Cabeza, J. M., Gao, L., Pardal, R., López‐Barneo, J., & Ortega‐Sáenz, P. (2023) · The Journal of Physiology · doi:10.1113/jp283897 · Cited by 11

Druggable Biomarkers Altered in Clear Cell Renal Cell Carcinoma: Strategy for the Development of Mechanism-Based Combination Therapy

Rustum, Y. M., Reis, R. J., & Rustum, T. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020902 · Cited by 11

Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

Li, W., Chen, Y.-C., Lin, Y., Zou, Y.-Q., Hu, G.-S., Yang, J.-J., Nie, X. Y., Li, M.-Y., Wang, Y., He, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115487 · Cited by 12

Dual Roles of Hypoxia-Inducible Factor 1 in Acute Lung Injury: Tissue-Specific Mechanisms and Therapeutic Modulation

Jia, J., Zhang, Y., Lu, Q., Tian, S., Zhao, Y., & Fan, H. (2025) · Cells · doi:10.3390/cells14141089 · Cited by 12

Microenvironmental Factors Modulating Tumor Lipid Metabolism: Paving the Way to Better Antitumoral Therapy

Cai, L., Ying, M., & Wu, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.777273 · Cited by 9

Improving the synergistic combination of programmed death‐1/programmed death ligand‐1 blockade and radiotherapy by targeting the hypoxic tumour microenvironment

Mudassar, F., Shen, H. M., Cook, K. M., & Hau, E. K. C. (2022) · Journal of Medical Imaging and Radiation Oncology · doi:10.1111/1754-9485.13416 · Cited by 10

Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells

Joe, N. S., Wang, Y., Oza, H. H., Godet, I., Milki, N., Riggins, G. J., & Gilkes, D. M. (2023) · Cancers · doi:10.3390/cancers15041330 · Cited by 9

EPAS1 resistance to miRNA-based regulation contributes to prolonged expression of HIF-2 during hypoxia in human endothelial cells

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