Cited by 309Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerHepatocellular Carcinoma Treatment and Prognosis

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HIF Inhibitors: Status of Current Clinical Development

Fallah, Jaleh, Rini, Brian I.·2019·Current Oncology Reports

DOI 10.1007/s11912-019-0752-z

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Abstract

Purpose of review In this review, the importance of the hypoxia inducible factor (HIF) pathway in tumorigenesis and cancer treatment outcomes will be discussed. The outcomes of phase II and III clinical trials of direct HIF inhibitors in the treatment of cancer will be reviewed.Recent findings The HIF signaling pathway is activated by tumor-induced hypoxia or by inactivating mutations of the VHL gene. HIF is a transcription factor which regulates the expression of genes involved in adjusting mechanisms to hypoxia such as angiogenesis or apoptosis as well as tumor growth, invasion, and metastasis. The HIF pathway has a key role in development of resistance to different treatment modalities and higher expression of the HIF molecule is associated with poor prognosis. Clinical studies of the HIF inhibitors in patients with advanced/refractory cancers suggest benefit and warrant further studies of the HIF inhibitors either as a single agent or in combination with other therapeutic agents.

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Authors: Fallah, J., & Rini, B. I.
Affiliations: Cleveland Clinic (US)
Corresponding author: Rini, Brian I.
ORCID: Fallah, Jaleh
Rini, Brian I.
Venue: Current Oncology Reports
Publisher: Springer Science and Business Media LLC
Published: 2019-01
Volume: 21
Issue: 1
Pages: 6-6
ISSN: 1523-3790 (ISSN-L)
1534-6269
DOI: 10.1007/s11912-019-0752-z
OpenAlex: W2913218828
Cited by: 308
References: 62
Citations by year: 2026: 10 · 2025: 20 · 2024: 43 · 2023: 52 · 2022: 68 · 2021: 64 · 2020: 45 · 2019: 5
FWCI: 4.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Oncology Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords: hypoxia-inducible factor, HIF inhibitors, tumor hypoxia, VHL mutation, angiogenesis, apoptosis, metastasis, treatment resistance, advanced cancer, clinical trials, combination therapy
MeSH terms: Antineoplastic Agents, Carcinoma, Renal Cell, Clinical Trials as Topic, Humans, Kidney Neoplasms, Prognosis, Research Design, Hypoxia-Inducible Factor 1, alpha Subunit

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