The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Central sensitization in fibromyalgia and other musculoskeletal disorders
Abstract
Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by nociceptive stimuli (hyperalgesia), or increased referred pain areas with associated somatosensory changes. Some manifestations of sensitization, such as expanded referred muscle pain areas in patients with chronic musculoskeletal pain, can be explained from animal experiments showing extrasegmental spread of sensitization. An important part of the pain manifestations (eg, tenderness and referred pain) related to chronic musculoskeletal disorders may result from peripheral and central sensitization, which may play a role in the transition from acute to chronic pain.
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“Regarding the etiopathophysiology of FMS, while its etiology remains unknown, the pathophysiology of this chronic condition seems to be related to the sensitization of CNS processes, e.g., [5,22,23], which underlie the alterations in pain perception displayed by these patients, (e.g., allodynia and hyperalgesia) [24], deficient pain inhibition [25], temporal summation of pain [26] and other”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [24]
Citations
Cites
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Cited by
Sorted by citations
Sensitization in patients with painful knee osteoarthritis
Arendt‐Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven‐Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 992
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Self-citationAssessment of mechanisms in localized and widespread musculoskeletal pain
Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.107 · Cited by 547
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The effects of sleep deprivation on pain inhibition and spontaneous pain in women
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Metadata
- Authors
- Arendt-Nielsen, L., & Graven-Nielsen, T.
- Venue
- Current Pain and Headache Reports
- Published
- 2003-10
- Volume
- 7
- Issue
- 5
- Pages
- 355-361
- ISSN
- 1531-3433 (ISSN-L)
- 1534-3081
- OpenAlex
- W2161320464
- Cited by
- 219
- References
- 80
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 16 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 10
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Pain and Headache Reports (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- Danmarks Grundforskningsfond
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- central sensitization, fibromyalgia, chronic musculoskeletal pain, muscle hyperalgesia, referred pain, allodynia, transition from acute to chronic pain
- MeSH terms
- Fibromyalgia, Humans, Musculoskeletal Diseases, Nerve Endings, Neuropeptides, Nociceptors, Pain
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