Cited by 219Pain Mechanisms and TreatmentsFibromyalgia and Chronic Fatigue Syndrome ResearchPain Management and Treatment

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Central sensitization in fibromyalgia and other musculoskeletal disorders

Arendt-Nielsen, Lars, Graven-Nielsen, Thomas·2003·Current Pain and Headache Reports

DOI 10.1007/s11916-003-0034-0

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Abstract

Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by nociceptive stimuli (hyperalgesia), or increased referred pain areas with associated somatosensory changes. Some manifestations of sensitization, such as expanded referred muscle pain areas in patients with chronic musculoskeletal pain, can be explained from animal experiments showing extrasegmental spread of sensitization. An important part of the pain manifestations (eg, tenderness and referred pain) related to chronic musculoskeletal disorders may result from peripheral and central sensitization, which may play a role in the transition from acute to chronic pain.

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Authors: Arendt-Nielsen, L., & Graven-Nielsen, T.
Venue: Current Pain and Headache Reports
Publisher: Springer Science and Business Media LLC
Published: 2003-10
Volume: 7
Issue: 5
Pages: 355-361
ISSN: 1531-3433 (ISSN-L)
1534-3081
DOI: 10.1007/s11916-003-0034-0
OpenAlex: W2161320464
Cited by: 219
References: 80
Citations by year: 2026: 5 · 2025: 6 · 2024: 16 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 10
FWCI: 1.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Pain and Headache Reports (publishedVersion)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders: Danmarks Grundforskningsfond
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: central sensitization, fibromyalgia, chronic musculoskeletal pain, muscle hyperalgesia, referred pain, allodynia, transition from acute to chronic pain
MeSH terms: Fibromyalgia, Humans, Musculoskeletal Diseases, Nerve Endings, Neuropeptides, Nociceptors, Pain

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Central sensitization in fibromyalgia and other musculoskeletal disorders

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