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Cited by 107Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesCognitive Functions and Memory

The DOI matches its Crossref record; 85 of the 86 references it cites were found in a registry or an index.

The cholinergic hypothesis of cognitive impairment caused by traumatic brain injury

Arciniegas, David B.·2003·Current Psychiatry Reports
DOI 10.1007/s11920-003-0074-5
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Abstract

Cognitive impairments are among the most common neuropsychiatric sequelae of traumatic brain injury at all levels of severity. Cerebral cholinergic neurons and their ascending projections are particularly vulnerable to acute and chronic traumatically mediated dysfunction. In light of the important role of acetylcholine in arousal, attention, memory, and other aspects of cognition, cerebral cholinergic systems contribute to and may also be a target for pharmacologic remediation among individuals with post-traumatic cognitive impairments. This article will review the evidence in support of this hypothesis. Evidence of relatively selective damage to cholinergic injury, the development of persistent anticholinergic sensitivity, and the effects of cholinergic augmentation on memory performance are presented first. Thereafter, neuropathologic, electrophysiologic, and pharmacologic evidence of cholinergic dysfunction after traumatic brain injury in humans is reviewed. Finally, future directions for investigation of the cholinergic hypothesis and possible clinical applications of this information are discussed.

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Crossref · 10.1007/s11920-003-0074-5

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85 of 85 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 86 references

Research works printed but not linked: 2

  1. Gronwall D: Cumulative and persisting effects of concussion on attention and cognition. In Mild Head Injury. Edited by Levin HS, Eisenberg HM, Benton AL. New York: Oxford University Press; 1989.
  2. Bickford-Wimer PC, Nagamoto H, Johnson R, et al.: Auditory sensory gating in hippocampal systems: a model system in the rat. Biol Psychiatry 1989, 27:183–192. · DOI

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Metadata

Authors
Arciniegas, D. B.
Affiliations
HealthONE Spalding Rehabilitation Hospital (US)
Corresponding author
Arciniegas, David B.
ORCID
Arciniegas, David B.
Venue
Current Psychiatry Reports
Publisher
Springer Science and Business Media LLC
Published
2003-09
Volume
5
Issue
5
Pages
391-399
ISSN
  • 1523-3812 (ISSN-L)
  • 1535-1645
DOI
10.1007/s11920-003-0074-5
OpenAlex
W2021978868
Cited by
107
References
86
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 10 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 7 · 2017: 2 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Psychiatry Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
traumatic brain injury, cognitive impairment, cholinergic hypothesis, acetylcholine, cholinergic neurons, memory, post-traumatic cognitive impairment, cholinergic dysfunction
MeSH terms
Acetylcholine, Animals, Brain, Brain Injuries, Cognition, Cognition Disorders, Electrophysiology, Humans, Receptors, Cholinergic

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