The genetics of ADHD: A literature review of 2005
Abstract
Investigations into the genetic basis of attention-deficit/hyperactivity disorder (ADHD) continue to yield compelling results as candidate gene studies reveal more information about this elusive disorder. Family, twin, and adoption studies further the notion that ADHD is a highly heritable disorder with direct genetic and environmental influence. The year 2005 saw many ADHD candidate gene studies, with most focused on the catecholaminergic candidates. Although many genes were studied in 2005, a large portion of findings has been supportive of the roles of dopaminergic genes' relationship to clinical phenotypes and drug response. These studies often require replication. Clinical implications continue to be speculative, as larger sample sizes are needed to validate findings to the general population. Further understanding of endophenotypes and the impact of comorbidities also is necessary for proper clinical intervention. Forthwith, we provide a summary of ADHD genetic studies published in 2005.
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Recent meta-analyses of candidate gene association studies found consistent evidence of significant associations between ADHD and polymorphisms in several candidate genes almost exclusively involved in the regulation of dopaminergic and serotonergic transmission, including DAT1, DRD4, DRD5, 5-HTT, HTR1B, and SNAP25.
“Recent meta-analyses of candidate gene association studies have found consistent evidence of significant associations between ADHD and polymorphisms in several candidate genes that are almost exclusively involved in the regulation of dopaminergic and serotonergic transmission (including the dopamine transporter (DAT1) gene, the dopamine D4 receptor (DRD4) gene, the dopamine D5 receptor (DRD5) gene”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [441]
Cites
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Self-citationGeneral hospital psychiatry: the Italian experience.
Faraone, S. V., Sergeant, J. A., Gillberg, C., & Biederman, J. (2003) · Europe PMC (PubMed Central) · Cited by 1,277 · see citing works
Self-citationNeurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948 · see citing works
A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
Fisher, S. E., Francks, C., McCracken, J. T., McGough, J. J., Marlow, A., MacPhie, I. L., Newbury, D., Crawford, L., Palmer, C. G. S., Woodward, J., et al. (2002) · American Journal of Human Genetics · doi:10.1086/340112 · Cited by 318 · see citing works
Which treatment for whom for ADHD? Moderators of treatment response in the MTA.
Owens, E. B., Hinshaw, S. P., KRAEMER, H. C., Arnold, L. E., Abikoff, H., Cantwell, D. P., Conners, C. K., Elliott, G. R., Greenhill, L. L., Hechtman, L. T., et al. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.3.540 · Cited by 275 · see citing works
Bakker, S. C., Meulen, E. M. V. D., Buitelaar, J. K., Sandkuijl, L. A., Pauls, D. L., Monsuur, A. J., Slot, R. V. ‘., Minderaa, R. B., Gunning, W. B., Pearson, P. L., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/375143 · Cited by 257 · see citing works
Association of the Dopamine Transporter Gene (DAT1) With Poor Methylphenidate Response
Winsberg, B. G., & Comings, D. E. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199912000-00006 · Cited by 245 · see citing works
Smalley, S. L., Kustanovich, V., Minassian, S. L., Stone, J. L., Ogdie, M. N., McGough, J. J., McCracken, J. T., MacPhie, I. L., Francks, C., Fisher, S. E., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342732 · Cited by 240 · see citing works
Attention-Deficit/Hyperactivity Disorder Endophenotypes
Doyle, A. E., Willcutt, E. G., Seidman, L. J., Biederman, J., Chouinard, V., Silva, J. A., & Faraone, S. V. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.015 · Cited by 225 · see citing works
Self-citationSupport for association between ADHD and two candidate genes: NET1 and DRD1
Bobb, A. J., Addington, A. M., Sidransky, E., Gornick, M. C., Lerch, J. P., GREENSTEIN, D. K., CLASEN, L. S., Sharp, W. S., Inoff‐Germain, G., Vrièze, F. W., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30142 · Cited by 223 · see citing works
COMT Polymorphisms and Anxiety-Related Personality Traits
Stein, M. B., Fallin, M. D., Schork, N. J., & Gelernter, J. E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300787 · Cited by 222 · see citing works
Cornish, K. M., Manly, T., Savage, R., Swanson, J., Morisano, D., Butler, N., Grant, C., Cross, G., Bentley, L., & Hollis, C. P. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001641 · Cited by 220 · see citing works
Arcos‐Burgos, M., Castellanos, F. X., Pineda, D. A., Lopera, F. J., Palacio, J. D., Palacio, L. G., Rapoport, J. L., Berg, K. A., Wilson, J., & Muenke, M. (2004) · The American Journal of Human Genetics · doi:10.1086/426154 · Cited by 211 · see citing works
Functional Effects of the DAT1 Polymorphism on EEG Measures in ADHD
Loo, S. K., SPECTER, E., Smolen, A., Hopfer, C. J., Teale, P. D., & Reite, M. L. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046890.27264.88 · Cited by 169 · see citing works
Candidate gene studies of attention-deficit/hyperactivity disorder.
Faraone, S. V., & Khan, S. (2006) · PubMed · Cited by 165 · see citing works
Self-citationA genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs
Hebebrand, J., Dempfle, A., Saar, K., Thiele, H., Herpertz-Dahlmann, B., Linder, M., Kiefl, H., Remschmidt, H., Hemminger, U., Warnke, A., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001761 · Cited by 159 · see citing works
Dopamine Transporter Genotype and Methylphenidate Dose Response in Children with ADHD
Stein, M. A., Waldman, I. D., Sarampote, C. S., Seymour, K. E., Robb, A. S., Conlon, C. J., Kim, S., & Cook, E. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300718 · Cited by 144 · see citing works
Hamarman, S., Fossella, J., Ülger, C., Brimacombe, M. B., & Dermody, J. J. (2004) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2004.14.564 · Cited by 118 · see citing works
Román, T., Schmitz, M., Polanczyk, G. V., Eizirik, M., Rohde, L., & Hutz, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20018 · Cited by 94 · see citing works
The serotonin transporter gene as a QTL for ADHD
Curran, S., Purcell, S., Craig, I., Asherson, P., & Sham, P. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30118 · Cited by 91 · see citing works
Domschke, K., Sheehan, K., Lowe, N., Kirley, A., Mullins, C., O’Sullivan, R. J., Freitag, C., Becker, T., Conroy, J., Fitzgerald, M., et al. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30158 · Cited by 89 · see citing works
A Systematic Evaluation of ADHD and Comorbid Psychopathology in a Population-Based Twin Sample
Volk, H. E., Neuman, R. J., & Todd, R. D. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000166173.72815.83 · Cited by 88 · see citing works
Leung, P. W. L., Lee, C., Hung, S. F., Ho, T. P., Tang, C. P., Kwong, S., Leung, S. Y., Yuen, S. T., Lieh‐Mak, F., Oosterlaan, J., et al. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30129 · Cited by 85 · see citing works
Kirley, A., Lowe, N., Mullins, C., McCarron, M., Daly, G., Waldman, I. D., Fitzgerald, M., Gill, M., & Hawi, Z. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30072 · Cited by 79 · see citing works
Lowe, N., Kirley, A., Mullins, C., Fitzgerald, M., Gill, M., & Hawi, Z. (2004) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30071 · Cited by 52 · see citing works
Serotonin 5‐HT1B receptor gene and attention deficit hyperactivity disorder in Chinese Han subjects
Li, J., Wang, Y.-F., Zhou, R., Zhang, H.-B., Yang, L., Wang, B., Khan, S., & Faraone, S. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30075 · Cited by 46 · see citing works
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DENNIS, M., FRANCIS, D. J., CIRINO, P. T., SCHACHAR, R., BARNES, M. A., & FLETCHER, J. M. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709090481 · Cited by 875 · see citing works
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Waite, R. (2010) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2010.00254.x · Cited by 43 · see citing works
Braun, C. M. J. (2007) · Laterality: Asymmetries of Body, Brain and Cognition · doi:10.1080/13576500701458875 · Cited by 24 · see citing works
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- Authors
- Khan, S. A., & Faraone, S. V.
- Affiliations
- SUNY Upstate Medical University (US)
- Corresponding author
- Faraone, Stephen V.
- Venue
- Current Psychiatry Reports
- Published
- 2006-10
- Volume
- 8
- Issue
- 5
- Pages
- 393-397
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2063720382
- Cited by
- 89
- References
- 26
- Citations by year
- 2024: 1 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 4
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- attention deficit hyperactivity disorder, ADHD genetics, heritability, candidate gene association, dopaminergic genes, twin and family studies, adoption studies, endophenotypes, comorbidities, drug response
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Catecholamines, Humans
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