Suicidal Behavior in Mood Disorders: Response to Pharmacological Treatment
Abstract
Suicidal behavior is strongly associated with depression, especially if accompanied by behavioral activation, dysphoria, or agitation. It may respond to some treatments, but the design of scientifically sound, ethical trials to test for therapeutic effects on suicidal behavior is highly challenging. In bipolar disorder, and possibly also unipolar major depression, an underprescribed medical intervention with substantial evidence of preventive effects on suicidal behavior is long-term treatment with lithium. It is unclear whether this effect is specifically antisuicidal or reflects beneficial effects of lithium on depression, mood instability, and perhaps aggression and impulsivity. Antisuicidal effects of anticonvulsant mood stabilizers (carbamazepine, lamotrigine, valproate) appear to be less than with lithium. Further evaluation is needed for potential antisuicidal effects of atypical antipsychotics with growing evidence of efficacy in depression, particularly acute bipolar depression, while generally lacking risk of inducing agitation, mania, or mood instability. Short-term and long-term value and safety of antidepressants are relatively secure for unipolar depression but uncertain and poorly tested for bipolar depression; their effects on suicidal risk in unipolar depression may be age-dependent. Sedative anxiolytics are virtually unstudied as regards suicidal risks. Adequate management of suicidal risks in mood disorder patients requires comprehensive, clinically skillful monitoring and timely interventions.
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Current treatments, including pharmacological treatment of suicidal emerging adults, have limited effects.
“Current treatments, including pharmacological treatment of suicidal emerging adults, have limited effects [11, 12].”
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Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
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“Current treatments, including pharmacological treatment of suicidal emerging adults, have limited effects [11, 12].”
Background
- Authors
- Tondo, L., & Baldessarini, R. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Tondo, Leonardo
- Venue
- Current Psychiatry Reports
- Published
- 2016-08-20
- Volume
- 18
- Issue
- 9
- Pages
- 88-88
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2516851151
- Cited by
- 71
- References
- 124
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 12 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 22 · 2017: 8 · 2016: 2
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- suicidal behavior, mood disorders, depression, bipolar disorder, bipolar depression, lithium, antisuicidal effects, mood stabilizers, antiepileptic drugs, carbamazepine, lamotrigine, valproic acid, atypical antipsychotics, antidepressants, suicide risk, suicide prevention, treatment response
- MeSH terms
- Suicide Prevention, Behavioral Symptoms, Drug Therapy, Humans, Psychotropic Drugs, Suicide, Treatment Outcome, Mood Disorders, Risk Adjustment, Suicidal Ideation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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