The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis
Open accessAbstract
Articular cartilage injuries and degenerative joint diseases are responsible for progressive pain and disability in millions of people worldwide, yet there is currently no treatment available to restore full joint functionality. As the tissue functions under mechanical load, an understanding of the physiologic or pathologic effects of biomechanical factors on cartilage physiology is of particular interest. Here, we highlight studies that have measured cartilage deformation at scales ranging from the macroscale to the microscale, as well as the responses of the resident cartilage cells, chondrocytes, to mechanical loading using in vitro and in vivo approaches. From these studies, it is clear that there exists a complex interplay among mechanical, inflammatory, and biochemical factors that can either support or inhibit cartilage matrix homeostasis under normal or pathologic conditions. Understanding these interactions is an important step toward developing tissue engineering approaches and therapeutic interventions for cartilage pathologies, such as osteoarthritis.
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Cites
Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,076
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
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Differential activation of transcription factors induced by Ca2+ response amplitude and duration
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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
Glasson, S. S., Askew, R., Sheppard, B., Carito, B., Blanchet, T., Ma, H.-L., Flannery, C. R., Peluso, D., Kanki, K., Yang, Z., et al. (2005) · Nature · doi:10.1038/nature03369 · Cited by 1,253
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Mauck, R. L., Soltz, M. A., Wang, C. C. B., Wong, D. D., Chao, P.-H. G., Valhmu, W. B., Hung, C. T., & Ateshian, G. A. (2000) · Journal of Biomechanical Engineering · doi:10.1115/1.429656 · Cited by 976
The role of the chondrocyte in osteoarthritis
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Self-citation
Cited by
He, Y., Li, Z., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 380
Collins, K. H., Herzog, W., MacDonald, G. Z., Reimer, R. A., Rios, J. L., Smith, I. C., Zernicke, R. F., & Hart, D. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00112 · Cited by 308
Bone–cartilage crosstalk: a conversation for understanding osteoarthritis
Findlay, D. M., & Kuliwaba, J. S. (2016) · Bone Research · doi:10.1038/boneres.2016.28 · Cited by 283
Metadata
- Authors
- Sanchez-Adams, J., Leddy, H. A., McNulty, A. L., O’Conor, C. J., & Guilak, F.
- Venue
- Current Rheumatology Reports
- Published
- 2014-09-03
- Volume
- 16
- Issue
- 10
- Pages
- 451-451
- ISSN
- 1523-3774 (ISSN-L)
- 1534-6307
- OpenAlex
- W2134949545
- Cited by
- 313
- References
- 82
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Sanchez-Adams, J., Leddy, H. A., McNulty, A. L., O’Conor, C. J., & Guilak, F. (2014). The Mechanobiology of Articular Cartilage: Bearing the Burden of Osteoarthritis. Current Rheumatology Reports. https://doi.org/10.1007/s11926-014-0451-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
