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Cited by 283

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Bone–cartilage crosstalk: a conversation for understanding osteoarthritis

Open access
Findlay, David M, Kuliwaba, Julia S·2016·Bone Research

Abstract

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction (crosstalk) between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well-described progressive destructive changes in the articular cartilage, which parallel characteristic changes in the underlying bone. This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.

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Metadata

Authors
Findlay, D. M., & Kuliwaba, J. S.
Venue
Bone Research
Published
2016-09-20
Volume
4
Issue
1
Pages
16028-16028
ISSN
  • 2095-4700 (ISSN-L)
  • 2095-6231
OpenAlex
W2522849079
Cited by
283
References
87
FWCI
19.86
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Bone–cartilage crosstalk: a conversation for understanding osteoarthritis. https://app.cochat.ai/papers/10.1038/boneres.2016.28
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Findlay, D. M., & Kuliwaba, J. S. (2016). Bone–cartilage crosstalk: a conversation for understanding osteoarthritis. Bone Research. https://doi.org/10.1038/boneres.2016.28

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.