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Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists
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“With oral ingestion, after first-pass metabolism, tadalafil is approximately 80% bioavailable, compared to 40% and 15% with sildenafil and vardenafil, respectively (Francis and Corbin 2003).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Francis and Corbin 2003
In the citing paper
“The half-life of tadalafil is 17.5 hours in normal healthy men and 21.6 hours in elderly men, while the half-lives of sildenafil and vardenafil are similar at 4 hours (Francis and Corbin 2003).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Francis and Corbin 2003
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“the absorption of tadalafil is unaffected by fatty meals or alcohol consumption (Francis and Corbin 2003).”
From Tadalafil in the treatment of erectile dysfunction (2008) · cites this paper as Francis and Corbin 2003
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Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006 · cited 2×
“This process occurs selectively in the penile corpora cavernosa after sexual arousal because of the increased release of NO from the nonadrenergic, noncholinergic nerve endings in the penis and from the arterial endothelial cells of the penile vasculature [36, 37 ].”
BackgroundSildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke in Rats
Zhang, R., Wang, Y., Zhang, L., Zhang, Z., Tsang, W., Lu, M., Zhang, L., & Chopp, M. (2002) · Stroke · doi:10.1161/01.str.0000034399.95249.59 · Cited by 383
PHARMACOLOGY OF PHOSPHODIESTERASE‐5 INHIBITORS
Corbin, J., & Francis, S. (2002) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2002.tb11296.x · Cited by 260
Self-citation
Research works printed but not linked: 48
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Cited by
Tadalafil pharmacokinetics in healthy subjects
Forgue, S. T., Patterson, B. E., Bedding, A. W., Payne, C. D., Phillips, D. L., Wrishko, R. E., & Mitchell, M. I. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2005.02553.x · Cited by 284
Tucker, J., Fischer, T., Upjohn, L., Mazzera, D., & Kumar, M. (2018) · JAMA Network Open · doi:10.1001/jamanetworkopen.2018.3337 · Cited by 251
Tadalafil in the treatment of erectile dysfunction
Coward, R., & Carson, C. (2008) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s3336 · Cited by 138
Metadata
- Authors
- Francis, S. H., & Corbin, J. D.
- Venue
- Current Urology Reports
- Published
- 2003-11
- Volume
- 4
- Issue
- 6
- Pages
- 457-465
- ISSN
- 1527-2737
- 1534-6285
- Cited by
- 68
- References
- 3
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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