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Cited by 37Aluminum toxicity and tolerance in plants and animalsImmunotoxicology and immune responsesHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Effects of Aluminum on Immune Functions of Cultured Splenic T and B Lymphocytes in Rats

She, Yue, Wang, Nan, Chen, Chongxiao, Zhu, Yanzhu, Xia, Shiliang, Hu, Chongwei, Li, Yanfei·2012·Biological Trace Element Research
DOI 10.1007/s12011-011-9307-3
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Abstract

The effects of Aluminum (Al) exposure on immune functions of cultured splenic T and B lymphocytes of rats were studied. The lymphocytes were isolated from spleen of healthy male Wistar rats weighing 110-120 g. The cultured cells in RPMI-1640 medium were exposed to 0 (control group), 0.035 (low-dose group), 0.07 (medial-dose group), and 0.14 (high-dose group) mg/mL Al(3+) as aluminum trichloride (AlCl(3)) in an incubator under 5% CO(2) at 37°C for 24 h. The T and B lymphocyte proliferation was measured with a tetrazolium dye colorimetric assay. The levels of interleukin (IL)-2, IL-6, and tumor necrosis factor (TNF)-α were determined by iodine [(125)I] IL-2, IL-6, and TNF-α radioimmunoassay kits, respectively. The proportions of CD3(+), CD4(+), and CD8(+) T lymphocytes were measured with a flow cytometer. The results showed that the T and B lymphocyte proliferation, the levels of IL-2, IL-6, TNF-α, the proportions of CD3(+) and CD4(+) T lymphocytes, and the ratio of CD4(+)/CD8(+) T lymphocytes were lowered by Al treatments, while the proportion of CD8(+) T lymphocytes was increased. These findings indicate that Al exposure can inhibit the immune functions of splenic T and B lymphocytes of rats in vitro.

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Crossref · 10.1007/s12011-011-9307-3

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  • Immune functions of splenic B- and T-lymphocytes were inhibited in vitro by reduction of lymphocyte proliferation, cytokine secretion and proportions of CD-3(+) and CD-4(+) lymphocytes.

    “Immune functions of splenic B- and T-lymphocytes were inhibited in vitro by reduction of lymphocyte proliferation, cytokine secretion and proportions of CD-3(+) and CD-4(+) lymphocytes (She et al., 2012).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as She et al., 2012

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Research works printed but not linked: 33

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Metadata

Authors
She, Y., Wang, N., Chen, C., Zhu, Y., Xia, S., Hu, C., & Li, Y.
Affiliations
  • Northeast Agricultural University (CN)
  • China Agricultural University (CN)
  • Chinese Academy of Agricultural Sciences (CN)
Corresponding author
Li, Yanfei
ORCID
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2011-12-29
Volume
147
Issue
1-3
Pages
246-250
ISSN
  • 0163-4984 (ISSN-L)
  • 1559-0720
DOI
10.1007/s12011-011-9307-3
OpenAlex
W2049174621
Cited by
37
References
3
Citations by year
2026: 1 · 2025: 5 · 2023: 4 · 2022: 1 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 7 · 2013: 3
FWCI
3.85
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Biological Trace Element Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
aluminum toxicity, aluminum chloride, splenic T cells, splenic B cells, lymphocyte proliferation, interleukin-2, interleukin-6, TNF-α, CD4/CD8 ratio, CD3+ T cells, immunosuppression, rats
MeSH terms
Aluminum Chloride, Aluminum, Animals, B-Lymphocytes, Cells, Cultured, Chlorides, Dose-Response Relationship, Drug, Interleukin-2, Male, Radioimmunoassay, Spleen, T-Lymphocytes, Tumor Necrosis Factor-alpha, CD4-Positive T-Lymphocytes, Interleukin-6, Rats, Wistar, CD3 Complex, Aluminum Compounds, CD8-Positive T-Lymphocytes, Lymphocyte Count, Cell Proliferation, Rats

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