The TNF and TNF Receptor Superfamilies

Death Receptors: Signaling and Modulation

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An endotoxin-induced serum factor that causes necrosis of tumors

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The Fas Death Factor

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Toll-like receptors in the induction of the innate immune response

Aderem, A. A., & Ulevitch, R. J. (2000) · Nature · doi:10.1038/35021228 · Cited by 3,047 · see citing works

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

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Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

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Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

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Comparative Genomics of the Eukaryotes

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Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677 · see citing works

Cachectin and tumour necrosis factor as two sides of the same biological coin

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An Essential Role for Ectodomain Shedding in Mammalian Development

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,538 · see citing works

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

Mackay, F., Woodcock, S. A., Lawton, P., Ambrose, C. M., Baetscher, M., Schneider, P., Tschopp, J., & Browning, J. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1697 · Cited by 1,479 · see citing works

RANK is essential for osteoclast and lymph node development.

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TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409 · see citing works

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.

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T-Cell mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ.

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Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Kontoyiannis, D. L., Pasparakis, M., Pizarro, T. T., Cominelli, F., & Kollias, G. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80038-2 · Cited by 1,329 · see citing works

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.331 · Cited by 1,299 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

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Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246 · see citing works

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

Gross, J. A., Johnston, J. V., Mudri, S., Enselman, R., Dillon, S. R., Madden, K., Xu, W., Parrish-Novak, J. E., Foster, D., Lofton-Day, C., et al. (2000) · Nature · doi:10.1038/35010115 · Cited by 1,175 · see citing works

TNF? and the TNF receptor superfamily: Structure-function relationship(s)

Idriss, H. T., & Naismith, J. H. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20000801)50:3 · Cited by 1,175 · see citing works

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

Carballo, E., Lai, W. S., & Blackshear, P. J. (1998) · Science · doi:10.1126/science.281.5379.1001 · Cited by 1,162 · see citing works

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

Pasparakis, M., Alexopoulou, L., Episkopou, V., & Kollias, G. A. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.4.1397 · Cited by 1,160 · see citing works

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

Moore, P. A., Belvedere, O., ORR, A. S., Pieri, K., LaFleur, D. W., Feng, P., Soppet, D. R., Charters, M., Gentz, R., Parmelee, D. C., et al. (1999) · Science · doi:10.1126/science.285.5425.260 · Cited by 1,143 · see citing works

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis, and regulation of bone mass and calcium metabolism.

Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119 · see citing works

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

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Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070 · see citing works

Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous systemPreprint

Bibel, M., & Barde, Y. (2000) · Genes & Development · doi:10.1101/gad.841400 · Cited by 1,054 · see citing works

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

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MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

Lenardo, M. J., Chan, F. K.-M., Hornung, F., McFarland, H. F., Siegel, R. M., Wang, J., & Zheng, L. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.221 · Cited by 931 · see citing works

A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling

Chan, F. K.-M., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2351 · Cited by 856 · see citing works

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D. L., Stamatakis, K., Lin, J., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G. A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00210-5 · Cited by 801 · see citing works

A Pathogenetic Role for TNFα in the Syndrome of Cachexia, Arthritis, and Autoimmunity Resulting from Tristetraprolin (TTP) Deficiency

Taylor, G. A., Carballo, E., Lee, D. M., Lai, W. S., Thompson, M. J., Patel, D. D., Schenkman, D. I., Gilkeson, G. S., Broxmeyer, H. E., Haynes, B. F., et al. (1996) · Immunity · doi:10.1016/s1074-7613(00)80411-2 · Cited by 765 · see citing works

LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator

Mauri, D. N., Ebner, R., Montgomery, R. I., Kochel, K. D., Cheung, T. C., Yu, G.-L., Ruben, S. M., Murphy, M., Eisenberg, R. J., Cohen, G. H., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80455-0 · Cited by 757 · see citing works

The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756 · see citing works

Role of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

Papadakis, K. A., & Targan, S. R. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.289 · Cited by 714 · see citing works

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

Cenci, S., Weitzmann, M. N., Roggia, C., Namba, N., Novack, D., Woodring, J., & Pacifici, R. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11066 · Cited by 705 · see citing works

Cell suicide for beginners

RAFF, M. C. (1998) · Nature · doi:10.1038/24055 · Cited by 692 · see citing works

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

Gray, P. W., Aggarwal, B. B., Benton, C. V., Bringman, T. S., Henzel, W. J., Jarrett, J. A., Leung, D. W., Moffat, B., Ng, P., Svedersky, L. P., et al. (1984) · Nature · doi:10.1038/312721a0 · Cited by 641 · see citing works

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

Fu, Y., & Chaplin, D. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.399 · Cited by 615 · see citing works

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

Erickson, S. L., de Sauvage, F. J., Kikly, K. K., Carver-Moore, K., Pitts-Meek, S., Gillett, N. A., Sheehan, K. C. F., Schreiber, R. D., Goeddel, D. V., & Moore, M. W. (1994) · Nature · doi:10.1038/372560a0 · Cited by 587 · see citing works

The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution

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Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

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The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

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Enhanced Levels of Soluble and Membrane-Bound CD40 Ligand in Patients With Unstable Angina

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Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

Teng, Y.-T. A., Nguyen, H. P., Gao, X., Kong, Y., Gorczynski, R. M., Singh, B., Ellen, R. P., & Penninger, J. M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10763 · Cited by 494 · see citing works

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

Hughes, A. E., Ralston, S. H., Marken, J., Bell, C., Macpherson, H. K., Wallace, R. G. H., Hul, W. V., Whyte, M. P., Nakatsuka, K., Hovy, L., et al. (2000) · Nature Genetics · doi:10.1038/71667 · Cited by 481 · see citing works

BLC Expression in Pancreatic Islets Causes B Cell Recruitment and Lymphotoxin-Dependent Lymphoid Neogenesis

Luther, S. A., Lopez, T., Bai, W., Hanahan, D., & Cyster, J. G. (2000) · Immunity · doi:10.1016/s1074-7613(00)80199-5 · Cited by 468 · see citing works

Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Family: Adapter Proteins That Mediate Cytokine Signaling

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Follicular stromal cells and lymphocyte homing to follicles

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Lymphotoxin-α-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness

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Requirement for CD154 in the progression of atherosclerosis

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Triggering Cell Death

Hymowitz, S. G., Christinger, H. W., Fuh, G., Ultsch, M. H., O'Connell, M., Kelley, R. F., Ashkenazi, A., & de Vos, A. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80207-5 · Cited by 434 · see citing works

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

Kratz, A. F., Campos‐Neto, A., Hanson, M. S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1461 · Cited by 430 · see citing works

The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

Siegel, R. M., Chan, F. K.-M., Chun, H. J., & Lenardo, M. J. (2000) · Nature Immunology · doi:10.1038/82712 · Cited by 423 · see citing works

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

Monreal, A. W., Ferguson, B. M., Headon, D. J., Street, S. L., Overbeek, P. A., & Zonana, J. (1999) · Nature Genetics · doi:10.1038/11937 · Cited by 397 · see citing works

LIGHT, a TNF-Like Molecule, Costimulates T Cell Proliferation and Is Required for Dendritic Cell-Mediated Allogeneic T Cell Response

Tamada, K., Shimozaki, K., Chapoval, A. I., Zhai, Y., Su, J., Chen, S.-F., Hsieh, S.-L. E., Nagata, S., Ni, J., & Chen, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4105 · Cited by 391 · see citing works

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

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Involvement of a novel Tnf receptor homologue in hair follicle induction.

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Anti-Cytokine Therapy for Rheumatoid Arthritis

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Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

Alimzhanov, M. B., Kuprash, D. V., Kosco‐Vilbois, M. H., Luz, A., Turetskaya, R. L., Tarakhovsky, A., Rajewsky, K., Nedospasov, S. A., & Pfeffer, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9302 · Cited by 370 · see citing works

Structural basis for self-association and receptor recognition of human TRAF2

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Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

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Insights into programmed cell death through structural biology.

Fesik, S. (2000) · Cell · doi:10.1016/s0092-8674(00)00119-7 · Cited by 328 · see citing works

Caspase-independent Cell Killing by Fas-associated Protein with Death Domain

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Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

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The death domain: a module shared by proteins with diverse cellular functions

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The Taxonomy of Developmental Control in <i>Caenorhabditis elegans</i>

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Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

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NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

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Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

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The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

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Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection

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ICEBERG

Humke, E. W., Shriver, S. K., Starovasnik, M. A., Fairbrother, W. J., & Dixit, V. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00108-2 · Cited by 270 · see citing works

Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

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TNFRSF1A mutations and autoinflammatory syndromes

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Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.

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