Effect of Aluminum Exposure on Glucose Metabolism and Its Mechanism in Rats
Abstract
The effects of aluminum (Al) exposure on glucose metabolism and its mechanism were investigated. A total of 30 healthy Wistar male rats were randomly divided into two groups: control (GC) and experimental (GE). The GC group received intraperitoneal normal saline. The GE was established by intraperitoneal injected AlCl 3 solution at 10 mg/kg for 30 days. Fasting blood glucose (FBG) and serum levels of insulin (FINS) were measured. The insulin resistance index (HOMA-IR) and pancreatic β cell function index (HOMA-β) were calculated and analyzed with homeostasis model assessment (HOMA). Pancreatic tissue was taken for pathological examination. Glucose transporter 4 (GLUT4) expression in skeletal muscle was detected by quantitative PCR and Western blot. Levels of FBG and HOMA-IR in GE were higher than those in GC at day 10 and 20 (P < 0.05). FINS in GE were higher than those in GC at day 10 and 20, and lower than those in GC at day 30 (P < 0.05). HOMA-β in GE was lower than that of GC at every time point (P < 0.05). Pathology showed that pancreatic damage changed more profoundly with prolongation of time in GE. Expression levels of GLUT4 mRNA and protein in rat skeletal muscle in GE were significantly lower than those in GC (P < 0.05). The results suggested that Al exposure affected glucose metabolism through pancreatic damage and reduction of GLUT4 expression.
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Prediabetes and diabetes are due to pancreatic islet damage.
“prediabetes and diabetes due to pancreatic islet damage (Wei et al., 2018).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Wei et al., 2018
Elevated blood insulin level is associated with insulin resistance due to depletion of glucose transporter-4 protein expression in skeletal muscles during Al exposure.
“Elevated blood insulin level is associated with insulin resistance due to depletion of glucose transporter-4 protein expression in skeletal muscles during Al exposure (Wei et al., 2018).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Wei et al., 2018
Pancreatic β-cell function decreased as pancreatic damage occurred with progression of treatment.
“indicating that pancreatic β-cell function decreased as pancreatic damage occurred with progression of treatment (Wei et al., 2018).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Wei et al., 2018
Cites
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998 · see citing works
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395 · see citing works
“, 2018), inaction of membrane-bound enzymes, inhibition of calbindin protein level in enterocytic membrane (Cox and Dunn, 2001) and downregulation of GLUT4 protein expression in the membrane of skeletal muscle (Wei et al., 2018).”
BackgroundInfluential
- Authors
- Wei, X., Wei, H., Yang, D., Li, D., Yang, X., He, M., Lin, E., & Wu, B.
- Affiliations
- Youjiang Medical College for Nationalities (CN)
- Corresponding author
- Wu, Biaoliang
- Venue
- Biological Trace Element Research
- Published
- 2018-03-28
- Volume
- 186
- Issue
- 2
- Pages
- 450-456
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W2795221939
- Cited by
- 24
- References
- 1
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 1 · 2020: 1 · 2019: 4
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Guangxi Province (2014GXNS-FAA118216)
- Guangxi Provincial Research Innovation Program for College postgraduates (201601010)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- aluminum exposure, aluminum chloride, glucose metabolism, insulin resistance, HOMA-IR, beta-cell function, HOMA-β, fasting blood glucose, serum insulin, GLUT4, skeletal muscle, pancreatic injury, metal toxicity
- MeSH terms
- Aluminum, Animals, Blood Glucose, Fasting, Injections, Intraperitoneal, Insulin, Insulin Resistance, Male, Random Allocation, Gene Expression, Rats, Wistar, Muscle, Skeletal, Insulin-Secreting Cells, Glucose Transporter Type 4
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