Evaluation of blood serum iron concentration as an alternative biomarker for inflammation in dairy cows
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Abstract
This study aimed to clarify the relationship between acute phase protein (APP) concentrations and serum Fe concentrations to determine whether serum iron (Fe) can be clinically applied as a substitute for APPs in cows. One hundred five Holstein-Friesian breed lactating dairy cows were enrolled in this study. Cows with inflammatory diseases were 16 subclinical, and 15 severe mastitis cows, in addition to 15 mild and 16 severe sole ulcer cows. The plasma haptoglobin (HPT), alpha-1 acid glycoprotein (AGP), SAA, serum Fe levels, and other biochemical parameters in the cows were measured. The two-sample t-tests and multiple logistic regression analysis were used to compare the control and inflammatory disease groups. ROC analysis was used to evaluate the ability to diagnose inflammation disease. From the results, the proposed diagnostic cutoff value for plasma SAA and serum Fe concentrations to identify dairy cows with inflammatory diseases based on analyses of ROC curves were set at > 3.65 mg/l and < 120.50 µg/dl, respectively. Therefore, instead of using expensive inflammatory markers to evaluate the inflammatory state at the first treatment day for inflammatory diseases in cow, it shows the useful for screening with serum Fe concentration that can be measured easily and inexpensively as alternative inflammatory biomarkers.
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Serum iron concentration may offer a simple and cost-effective alternative to APPs for evaluating inflammatory diseases.
“Moreover, serum iron concentration may offer a simple and cost-effective alternative to APPs for evaluating inflammatory diseases [222].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [222]
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Cited by
Sorted by citations
Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview
Kamel, M. S., Davidson, J. L., & Verma, M. S. (2024) · Animals · doi:10.3390/ani14040627 · Cited by 76 · see citing works
“Moreover, serum iron concentration may offer a simple and cost-effective alternative to APPs for evaluating inflammatory diseases [222].”
Background
- Authors
- Murakami, Y., Tsukano, K., Hirata, H., & Suzuki, K.
- Affiliations
- Rakuno Gakuen University (JP)
- Corresponding author
- Suzuki, Kazuyuki
- Venue
- Biological Trace Element Research
- Published
- 2023-01-09
- Volume
- 201
- Issue
- 10
- Pages
- 4710-4717
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W4313857465
- Cited by
- 5
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Biological Trace Element Research (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Milk Quality and Mastitis in Dairy Cows
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- serum iron, inflammatory markers, dairy cattle, acute phase proteins, subclinical mastitis, sole ulcer, serum amyloid A, haptoglobin, alpha-1-acid glycoprotein, inflammatory disease diagnosis, Holstein cows
- MeSH terms
- Acute-Phase Proteins, Animals, Cattle, Cattle Diseases, Female, Inflammation, Lactation, Milk, Biomarkers, Serum
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