Serum iron concentration is candidate inflammatory marker for respiratory diseases in beef cows
Open accessAbstract
We hypothesized that the serum iron (Fe) concentration in cows with respiratory diseases is a satisfactory substitute for major inflammatory markers such as haptoglobin (HPT) and serum amyloid A (SAA). Twenty Japanese Black cows aged 279.6 ± 120.0 days were enrolled, and divided into respiratory diseases and control groups based on the presence of clinical findings of respiratory diseases. As a result, area under the receiver operating characteristic curves for plasma HPT, SAA and serum Fe concentrations for respiratory disease-associated systemic inflammation were excellent, at 1.00, 0.96 and 0.97, respectively. Therefore we confirmed that the serum Fe concentration is a satisfactory substitute for HPT and SAA in beef cows with respiratory diseases.
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Serum iron concentration has emerged as a potential substitute for Hp and SAA in diagnosing respiratory diseases in cattle.
“Serum iron concentration has emerged as a potential substitute for Hp and serum amyloid A (SAA) in diagnosing respiratory diseases in cattle [212].”
From Strategies for Bovine Respiratory Disease (BRD) Diagnosis and Prognosis: A Comprehensive Overview (2024) · cites this paper as [212]
The Abstract and conclusion state that serum iron is a satisfactory substitute for haptoglobin and SAA as an inflammatory marker in beef cows with respiratory diseases. The study involved 20 Japanese Black cows and assessed inflammation associated with respiratory disease; it does not establish its use for diagnosing respiratory diseases across cattle generally. (LLM, conf=0.84)
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KOSHIISHI, T., HISAEDA, K., Nasu, M., Shibutani, S., & Iwata, H. (2025) · Institutional Repositories DataBase (IRDB)
- Authors
- TSUKANO, K., FUKUDA, T., IKEDA, K., SATO, K., & SUZUKI, K.
- Affiliations
- Minami-Hokkaido Agricultural Mutual Aid Association, 74-2 Higashimae, Hokuto, Hokkaido 041-1214, Japan
- Rakuno Gakuen University (JP)
- Corresponding author
- SUZUKI, Kazuyuki
- Venue
- Journal of Veterinary Medical Science
- Published
- 2021
- Volume
- 83
- Issue
- 5
- Pages
- 824-828
- ISSN
- 0916-7250 (ISSN-L)
- 1347-7439
- PMC
- PMC8182307
- OpenAlex
- W3137637760
- Cited by
- 8
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Veterinary Medical Science (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Milk Quality and Mastitis in Dairy Cows
- Keywords
- serum iron, beef cows, respiratory diseases, inflammatory markers, haptoglobin, serum amyloid A, systemic inflammation, Japanese Black cattle, diagnostic biomarkers
- MeSH terms
- Serum Amyloid A Protein, Animals, Cattle, Cattle Diseases, Female, Haptoglobins, Iron, Biomarkers
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