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Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma

Wang, Huayi, Zhang, Xianhua, Huang, Liming, Li, Jia, Qu, Shuyun, Pan, Fenglian·2014·Cell Biochemistry and Biophysics
DOI 10.1007/s12013-014-9974-8
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Abstract

The objective of the study was to evaluate the expression of matrix metalloproteinase-14 (MMP-14) in cervical carcinoma and correlate its expression with clinicopathological parameters, recurrence, and survival of the patients. The expressions of MMP-14 in normal cervical mucosa and cervical carcinoma tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. The positive expression rate of MMP-14 in cervical carcinoma tissue was 81.6 %(111/136), and there was significant difference on their positive expression rates between in cervical carcinoma tissue and in normal cervical mucosa(22.4 %)(13/58)(P < 0.05);The positive expression rates of MMP-14 in patients with poor histologic differentiation, lymph node metastasis, and recurrence group were heightened. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expressions of MMP-14 revealed a highly significant difference in human cervical carcinoma tissue (P < 0.05), which suggests that overexpression of MMP-14 is associated with a worse prognosis. The MMP-14 which promotes angiogenes is associated with lymph node metastasis, vascular invasion, and poor prognosis of cervical carcinoma. The current study shows that MMP-14 may be an independent prognostic factor for cervical carcinoma patients.

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Metadata

Authors
Wang, H., Zhang, X., Huang, L., Li, J., Qu, S., & Pan, F.
Venue
Cell Biochemistry and Biophysics
Publisher
Springer Science and Business Media LLC
Published
2014-05-01
Volume
70
Issue
2
Pages
729-734
ISSN
  • 1085-9195
  • 1559-0283
DOI
10.1007/s12013-014-9974-8
Cited by
16
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma. https://app.cochat.ai/papers/10.1007/s12013-014-9974-8
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Wang, H., Zhang, X., Huang, L., Li, J., Qu, S., & Pan, F. (2014). Matrix Metalloproteinase-14 Expression and Its Prognostic Value in Cervical Carcinoma. Cell Biochemistry and Biophysics. https://doi.org/10.1007/s12013-014-9974-8