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Role of membrane potential in the regulation of cell proliferation and differentiation

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Sundelacruz, Sarah, Levin, Michael, Kaplan, David L.·2009·Stem Cell Reviews and Reports
DOI 10.1007/s12015-009-9080-2PMC PMC10467564
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Abstract

Biophysical signaling, an integral regulator of long-term cell behavior in both excitable and non-excitable cell types, offers enormous potential for modulation of important cell functions. Of particular interest to current regenerative medicine efforts, we review several examples that support the functional role of transmembrane potential (V(mem)) in the regulation of proliferation and differentiation. Interestingly, distinct V(mem) controls are found in many cancer cell and precursor cell systems, which are known for their proliferative and differentiation capacities, respectively. Collectively, the data demonstrate that bioelectric properties can serve as markers for cell characterization and can control cell mitotic activity, cell cycle progression, and differentiation. The ability to control cell functions by modulating bioelectric properties such as V(mem) would be an invaluable tool for directing stem cell behavior toward therapeutic goals. Biophysical properties of stem cells have only recently begun to be studied and are thus in need of further characterization. Understanding the molecular and mechanistic basis of biophysical regulation will point the way toward novel ways to rationally direct cell functions, allowing us to capitalize upon the potential of biophysical signaling for regenerative medicine and tissue engineering.

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  • A hyperpolarized Vm is required during stem cell maturation.

    “In particular, a hyperpolarized Vm is required during stem cell maturation (Sundelacruz et al., 2009).”

    From Membrane potential and cancer progression (2013) · cites this paper as Sundelacruz et al., 2009

    The section ‘Functional Role of Vmem Signaling During Differentiation’ (page not provided) says hyperpolarization was necessary for osteogenic and adipogenic differentiation of human mesenchymal stem cells. The claim extends that finding to stem cell maturation generally, which the passage does not establish. (LLM, conf=0.84)

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Authors
Sundelacruz, S., Levin, M., & Kaplan, D. L.
Affiliations
Tufts University (US)
Corresponding author
Kaplan, David L.
ORCID
Venue
Stem Cell Reviews and Reports
Publisher
Springer Science and Business Media LLC
Published
2009-06-27
Volume
5
Issue
3
Pages
231-246
ISSN
  • 1550-8943 (ISSN-L)
  • 1558-6804
DOI
10.1007/s12015-009-9080-2
PMC
PMC10467564
OpenAlex
W2170070762
Cited by
489
References
1
Citations by year
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FWCI
5.78
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Stem Cell Reviews and Reports (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (00001, HD055850, EB002520)
  • National Highway Traffic Safety Administration (DTNH22-06-G-00001)
  • National Institute of General Medical Sciences (R01GM078484, GM078484)
  • National Institute of Biomedical Imaging and Bioengineering (P41EB002520)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD055850, HD055850-01)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
membrane potential, bioelectric signaling, cell proliferation, cell differentiation, stem cells, cell cycle progression, cancer cells, precursor cells, regenerative medicine, tissue engineering
MeSH terms
Animals, Biophysics, Cell Cycle, Cell Differentiation, Electrophysiology, Gene Expression Regulation, Humans, Membrane Potentials, Models, Biological, Regeneration, Stem Cells, Signal Transduction, Tissue Engineering, Cell Proliferation

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