The DOI matches its Crossref record; 249 of the 249 references it cites were found in a registry or an index.
A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics
Open accessAbstract
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory response. NETs can play a role in enhancement of the inflammation seen in autoimmune diseases including psoriasis, rheumatoid arthritis, and systemic lupus erythematosis. In addition, autoinflammatory diseases such as gout have been associated with NETosis. Inhibition of NETs may decrease the severity of many diseases improving survival. Herein, we describe NETosis in different diseases focusing on the detrimental effect of NETs and outline possible therapeutics that can be used to mitigate netosis. There is a need for more studies and clinical trials on these and other compounds that could prevent or destroy NETs, thereby decreasing damage to patients.
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Cites
1 retracted
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Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
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Acute abdomen in a 54-year-old COVID-19 patient: a case report
Holleb, P., Patel, P., Saxena, P., Beniwal, J., & Zuberi, J. (2021) · Journal of Surgical Case Reports · doi:10.1093/jscr/rjab198 · Cited by 3
Metadata
- Authors
- Mutua, V., & Gershwin, L. J.
- Venue
- Clinical Reviews in Allergy & Immunology
- Published
- 2020-08-01
- Volume
- 61
- Issue
- 2
- Pages
- 194-211
- ISSN
- 1080-0549 (ISSN-L)
- 1559-0267
- OpenAlex
- W3046314728
- Cited by
- 639
- References
- 249
- FWCI
- 17.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mutua, V., & Gershwin, L. J. (2021). A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics. Clinical Reviews in Allergy & Immunology. https://doi.org/10.1007/s12016-020-08804-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
