The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Adverse Stress, Hippocampal Networks, and Alzheimer’s Disease
Open accessAbstract
Recent clinical data have implicated chronic adverse stress as a potential risk factor in the development of Alzheimer’s disease (AD) and data also suggest that normal, physiological stress responses may be impaired in AD. It is possible that pathology associated with AD causes aberrant responses to chronic stress, due to potential alterations in the hypothalamic–pituitary–adrenal (HPA) axis. Recent study in rodent models of AD suggests that chronic adverse stress exacerbates the cognitive deficits and hippocampal pathology that are present in the AD brain. This review summarizes recent findings obtained in experimental AD models regarding the influence of chronic adverse stress on the underlying cellular and molecular disease processes including the potential role of glucocorticoids. Emerging findings suggest that both AD and chronic adverse stress affect hippocampal neural networks in a similar fashion. We describe alterations in hippocampal plasticity, which occur in both chronic stress and AD including dendritic remodeling, neurogenesis, and long-term potentiation. Finally, we outline potential roles for oxidative stress and neurotrophic factor signaling as the key determinants of the impact of chronic stress on the plasticity of neural networks and AD pathogenesis.
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Cites
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Cited by
Depression and risk of developing dementia
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High Cortisol and the Risk of Dementia and Alzheimer’s Disease: A Review of the Literature
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Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
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Metadata
- Authors
- Rothman, S. M., & Mattson, M. P.
- Venue
- NeuroMolecular Medicine
- Published
- 2009-11-27
- Volume
- 12
- Issue
- 1
- Pages
- 56-70
- ISSN
- 1535-1084 (ISSN-L)
- 1559-1174
- OpenAlex
- W2089189148
- Cited by
- 198
- References
- 44
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
