Screening for associated autoimmune disorders in Polish patients with Addison’s disease
Abstract
Autoimmune Addison's disease (AAD) is the main reason of primary adrenal failure. More than a half of patients display additional autoimmune conditions, which represent a considerable clinical concern. This study aimed to investigate the prevalence of concomitant autoimmune disorders in 85 Polish AAD patients (61 females, 24 males). Mean age at AAD onset was 34.6 ± 12.6 years, significantly earlier in males (P < 0.001). Sixty-nine patients presented positive serum antibodies to 21-hydroxylase and shorter AAD duration than those with negative results (P = 0.027). Seventy-three subjects suffered from coexisting autoimmune disorders. Serum autoantibodies against thyreoperoxidase, thyroglobulin, TSH receptor, glutamic acid decarboxylase, insulin, tyrosine phosphatase-like protein IA2, parietal cell H(+)/K(+)-ATPase, intrinsic factor and tissue transglutaminase were detectable in 71.8, 41.2, 4.7, 21.0, 4.9, 2.5, 49.4, 12.0 and 3.5% of patients, respectively. Antinuclear antibodies were found in 12.5%. Thyroid autoimmunity was most common (46 subjects with lymphocytic thyroiditis, 19 with Graves' disease), followed by atrophic gastritis (29.4%), pernicious anaemia (11.8%), hypergonadotropic hypogonadism (8.2%), vitiligo (8.2%), type 1 diabetes (7.1%), celiac disease (3.5%) and alopecia (2.4%). Gender differences were observed only for thyroid autoimmunity. Current study confirms particular tendency of AAD patients to develop other autoimmune disorders. Active search for concomitant…
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Vitamin B12 deficiency due to autoimmune gastritis is common in patients with primary adrenal insufficiency.
“Vitamin B12 deficiency due to autoimmune gastritis is common (7, 156), and vitamin B12 levels can also be monitored annually.”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [156]
Type 1 diabetes is less frequent in primary adrenal insufficiency patients in populations outside Scandinavia.
“Type 1 diabetes is present in 10 -15% of patients in Scandinavia (7), but is less frequent in other populations (156 -158).”
From Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline (2016) · cites this paper as [156]
Cites
Betterle, C., Dal Pra, C., Mantero, F., & Zanchetta, R. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0466 · Cited by 758 · see citing works
Laurberg, P., Wallin, G., Tallstedt, L., Abraham-Nordling, M., Lundell, G., & Tørring, O. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0450 · Cited by 428 · see citing works
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Bornstein, S. R., Allolio, B., Arlt, W., Barthel, A., Don-Wauchope, A., Hammer, G. D., Husebye, E. S., Merke, D. P., Murad, M. H., Stratakis, C. A., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1710 · Cited by 1,769 · see citing works
“Because the prevalence of celiac disease in PAI is about 5% (156, 162, 163), screening for tissue Table 4.”
BackgroundHusebye, E. S., Allolio, B., Arlt, W., Badenhoop, K., Bensing, S., Betterle, C., Falorni, A., Gan, E. H., Hulting, A. ‐., Kasperlik‐Zaluska, A., et al. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12162 · Cited by 403 · see citing works
Addison's disease: a survey on 633 patients in Padova
Betterle, C., Scarpa, R., Garelli, S., Morlin, L., Lazzarotto, F., Presotto, F., Coco, G., Masiero, S., Parolo, A., Albergoni, M. P., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0528 · Cited by 90 · see citing works
A current clinical overview of atrophic gastritis
Annibale, B., Esposito, G., & Lahner, E. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1718491 · Cited by 84 · see citing works
- Authors
- Fichna, M., Fichna, P., Gryczyńska, M., Walkowiak, J., Żurawek, M., & Sowiński, J.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Institute of Human Genetics (PL)
- Corresponding author
- Fichna, Marta
- Venue
- Endocrine
- Published
- 2010-03-16
- Volume
- 37
- Issue
- 2
- Pages
- 349-360
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2031294079
- Cited by
- 47
- References
- 2
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 3 · 2017: 8 · 2016: 7 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Keywords
- autoimmune Addison's disease, Addison's disease, autoimmune disease comorbidity, thyroid autoimmunity, atrophic gastritis, pernicious anemia, hypergonadotropic hypogonadism, vitiligo, type 1 diabetes, celiac disease, hair loss, autoantibodies, thyroid autoantibodies, age of onset, sex differences
- MeSH terms
- Addison Disease, Adult, Aged, Aged, 80 and over, Alopecia, Anemia, Pernicious, Autoantibodies, Autoimmune Diseases, Celiac Disease, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Humans, Male, Mass Screening, Middle Aged, Poland, Vitiligo, Prevalence, Seroepidemiologic Studies, Age of Onset
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