Vertebral fractures in males with prolactinoma
Abstract
Data on osteoporotic fractures in hyperprolactinemia are limited. An increased prevalence of radiological vertebral fractures was recently observed in women with prolactin (PRL)-secreting adenoma, whereas it is unknown whether this observation may reflect a more general increased risk of fractures in this disease and whether the prevalence of fractures in males is affected by gonadal status. Thirty-two males (median age 47 years, range: 22-79) with PRL-secreting pituitary adenoma (10 with microadenoma and 22 with macroadenoma) and 64 control males, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray absorptiometry at lumbar spine. Vertebral fractures were shown in 12 patients with PRL-secreting adenoma (37.5%) and in 5 controls (7.8%, P < 0.001). Fractured patients had lower BMD T-score (P = 0.007) and longer duration of disease (P < 0.001) as compared to patients who did not fracture. Fractures occurred more frequently (P = 0.03) in patients with untreated hyperprolactinemia versus patients treated with cabergoline whose frequency of vertebral fractures was still higher than control subjects. The prevalence of vertebral fractures was not significantly different between eugonadal and hypogonadal patients (33.3% vs. 38.5%; P = 0.8). Moreover, no significant (P = 0.4) difference in serum testosterone values was found between…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hyperprolactinemia causes secondary hypogonadism and may have sex hormone-independent effects on bone metabolism.
“Hyperprolactinemia causes secondary hypogonadism and may have sex hormone-independent effects on bone metabolism [17, 18].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [18]
Fractures were more frequent in patients with untreated hyperprolactinemia in comparison with patients treated with cabergoline.
“Fractures were more frequent in patients with untreated hyperprolactinemia in comparison with patients treated with cabergoline [18, 24].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [18]
Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia.
“Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia [18, 20–23].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [18]
Higher prevalence of radiological vertebral fractures occurs in women and men with PRL-secreting adenomas compared to controls.
“Mazziotti et al. have shown that higher prevalence of radiological vertebral fractures (VFs) occurs in women and men with PRL-secreting adenomas compared to controls [18, 24].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [18]
Males with prolactinomas who suffered fractures had lower BMD T-score and longer duration of disease, independently of age, serum IGF-1 and PRL values, frequency of macroadenomas, adrenal insufficiency, hypothyroidism, diabetes insipidus, parental history of fractures, cigarette smoking, and excessive alcohol consumption.
“Males with prolactinomas who suffered fractures had lower BMD T-score and longer duration of the disease, independently of the effects of age, serum IGF-1 and PRL values, frequency of macroadenomas, adrenal insufficiency, hypothyroidism, diabetes insipidus, parental history of fractures, cigarette smoking, and excessive alcohol consumption [18].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [18]
Cites
Prevalence of Vertebral Fractures in Men with Acromegaly
Mazziotti, G., Bianchi, A., Bonadonna, S., Cimino, V., Patelli, I., Fusco, A., Pontecorvi, A., De Marinis, L., & Giustina, A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0791 · Cited by 169 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Petersenn, S., Fleseriu, M., Casanueva, F. F., Giustina, A., Biermasz, N., Biller, B. M. K., Bronstein, M., Chanson, P., Fukuoka, H., Gadelha, M., et al. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00886-5 · Cited by 411 · see citing works
Self-citationMazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works
Self-citationGolds, G., Houdek, D., & Arnason, T. (2017) · International Journal of Endocrinology · doi:10.1155/2017/4602129 · Cited by 150 · see citing works
Inancli, S. S., Usluogullari, A., Ustu, Y., Caner, S., Tam, A. A., Ersoy, R., & Cakir, B. (2013) · Endocrine · doi:10.1007/s12020-012-9857-y · Cited by 59 · see citing works
Montejo, Á. L., Arango, C., Bernardo, M., Carrasco, J. L., Crespo-Facorro, B., Cruz, J. J., del Pino, J., García Escudero, M. A., García Rizo, C., González-Pinto, A., et al. (2016) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2015.11.003 · Cited by 55 · see citing works
Ledesma-Colunga, M. G., Adán, N., Ortiz, G., Solís-Gutiérrez, M., López-Barrera, F., Martínez de la Escalera, G., & Clapp, C. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1290-4 · Cited by 40 · see citing works
The role of the prolactin/vasoinhibin axis in rheumatoid arthritis: An integrative overview
Clapp, C., Adán, N., Ledesma-Colunga, M. G., Solís-Gutiérrez, M., Triebel, J., & Martínez de la Escalera, G. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2187-0 · Cited by 38 · see citing works
Pituitary Disorders and Osteoporosis
Bolanowski, M., Halupczok, J., & Jawiarczyk-Przybyłowska, A. (2015) · International Journal of Endocrinology · doi:10.1155/2015/206853 · Cited by 27 · see citing works
- Authors
- Mazziotti, G., Porcelli, T., Mormando, M., De Menis, E., Bianchi, A., Mejia, C., Mancini, T., De Marinis, L., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Ospedale di Stato della Repubblica di San Marino (SM)
- Corresponding author
- Mazziotti, Gherardo
- Venue
- Endocrine
- Published
- 2011-04-10
- Volume
- 39
- Issue
- 3
- Pages
- 288-293
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2021682202
- Cited by
- 109
- References
- 1
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 13 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 4
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- prolactinoma, vertebral fractures, hyperprolactinemia, osteoporosis, bone mineral density, hypogonadism, testosterone, cabergoline, pituitary adenoma
- MeSH terms
- Adult, Aged, Humans, Hyperprolactinemia, Hypogonadism, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Pituitary Neoplasms, Testosterone, Prolactinoma, Absorptiometry, Photon, Bone Density, Spinal Fractures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
