Prevalence of Vertebral Fractures in Men with Acromegaly
Abstract
Context Data on osteoporotic fractures in acromegaly are limited. An increased prevalence of radiological vertebral fractures was already observed in postmenopausal women with active acromegaly. It is unknown whether this observation may reflect a more general increased risk of fractures in acromegaly. Design This was a cross-sectional study. Setting The study was conducted at referral centers. Patients and control subjects Subjects included 40 males with acromegaly (25 patients with controlled disease and 15 patients with active disease) and 31 control males, with age and gonadal status comparable with the patients. Interventions Evaluation of vertebral fractures (quantitative morphometric analysis) and bone mineral density (BMD) at lumbar spine and total hip (dual energy X-ray absorptiometry) was done. Main outcome measure Vertebral fractures were assessed. Results Although BMD was not significantly different between acromegalic patients and control subjects, the prevalence of vertebral fractures was higher in acromegalic patients as compared with the control subjects (57.5 vs. 22.6%; chi(2): 8.7; P = 0.003). Fractured and nonfractured acromegalic patients showed no significant difference in age and BMD Z-score. However, acromegalic patients with fractures had serum IGF-I values significantly higher and duration of active disease significantly longer with respect to patients without fractures. Moreover, patients with fractures showed significantly longer untreated hypogonad…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hypogonadal patients with acromegaly are at higher risk of osteoporosis, particularly at sites composed predominantly of trabecular bone.
“Hypogonadal patients with acromegaly are at higher risk of osteoporosis, particularly at sites composed predominantly of trabecular bone, which has more intimate contact with the circulation and is influenced by sex steroids to a greater extent [34, 39, 40].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
BMD is a poor predictor of vertebral fractures in acromegaly.
“which makes BMD a poor fracture predictor [27, 30, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone.
“Patients with acromegaly have an increased risk of fractures, which might be correlated with insufficient quality of bone [26, 27, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
Vertebral fractures may be present in patients with normal or slightly decreased BMD.
“Vertebral fractures may be present in patients with normal or slightly decreased BMD, which makes BMD a poor fracture predictor [27, 30, 39, 42].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [39]
Cites
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824 · see citing works
Vestergaard, P. F. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0253-4 · Cited by 1,803 · see citing works
Systemic Complications of Acromegaly: Epidemiology, Pathogenesis, and Management
Colao, A. A. L., Ferone, D., Marzullo, P., & Lombardi, G. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0022 · Cited by 1,305 · see citing works
Giustina, A., & Veldhuis, J. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0353 · Cited by 1,253 · see citing works
Self-citationTang, B. M., Eslick, G. D., Nowson, C., Smith, C., & Bensoussan, A. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61342-7 · Cited by 1,248 · see citing works
Glucocorticoid-induced osteoporosis: pathophysiology and therapy
CANALIS, E. M., Mazziotti, G., Giustina, A., & Bilezikian, J. P. (2007) · Osteoporosis International · doi:10.1007/s00198-007-0394-0 · Cited by 1,118 · see citing works
Self-citationCriteria for Cure of Acromegaly: A Consensus Statement
Giustina, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.526 · Cited by 996 · see citing works
Self-citationGrowth Hormone, Insulin-Like Growth Factors, and the Skeleton
Giustina, A., Mazziotti, G., & CANALIS, E. M. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0036 · Cited by 910 · see citing works
Self-citationMechanisms of Anabolic Therapies for Osteoporosis
CANALIS, E. M., Giustina, A., & Bilezikian, J. P. (2007) · New England Journal of Medicine · doi:10.1056/nejmra067395 · Cited by 666 · see citing works
Self-citationGenant, H. K., Jergas, M. D., Palermo, L., Nevitt, M. C., Valentin, R. S., Black, D. M., & Cummings, S. R. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110716 · Cited by 634 · see citing works
Van Staa, T. P., Laan, R. F., Barton, I. P., Cohen, S., Reid, D. M., & Cooper, C. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11283 · Cited by 559 · see citing works
MacLean, C., Newberry, S., Maglione, M., McMahon, M., Ranganath, V., Suttorp, M., Mojica, W., Timmer, M., Alexander, A., McNamara, M., et al. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-3-200802050-00198 · Cited by 529 · see citing works
Differential effects of endocrine dysfunction on the axial and the appendicular skeleton.
Seeman, E., Wahner, H. W., Offord, K. P., Kumar, R., Johnson, W. J., & Riggs, B. L. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110570 · Cited by 460 · see citing works
Glucocorticoid-induced osteoporosis: an update
Mazziotti, G., Angeli, A., Bilezikian, J. P., Canalis, E., & Giustina, A. (2006) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2006.03.009 · Cited by 362 · see citing works
Self-citationGuidelines for Acromegaly Management
Melmed, S. K., Casanueva, F. F., Cavagnini, F., Chanson, P., Frohman, L. A., Grossman, A. B., Ho, K. K. Y., Kleinberg, D. L., Lamberts, S. W. J., Laws, E. R., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-011841 · Cited by 344 · see citing works
Self-citationAssociation Between Vertebral Fracture and Increased Mortality in Osteoporotic Patients
Jalava, T., Sarna, S. J., Pylkkänen, L. H., Mawer, B., Kanis, J. А., Selby, P. L., Davies, M., Adams, J. E., Francis, R. M., Robinson, J., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.7.1254 · Cited by 274 · see citing works
Consensus statement: medical management of acromegaly
Melmed, S. K., Casanueva, F. F., Cavagnini, F., Chanson, P., Frohman, L. A., Gaillard, R.-C., Ghigo, E., Ho, K. K. Y., Jaquet, P., Kleinberg, D. L., et al. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.02036 · Cited by 248 · see citing works
Self-citationEnhanced prediction of fracture risk combining vertebral fracture status and BMD
Siris, E. S., Genant, H. K., Laster, A. J., Chen, P., Misurski, D. A., & Krege, J. H. (2007) · Osteoporosis International · doi:10.1007/s00198-006-0306-8 · Cited by 196 · see citing works
Lunt, M., Felsenberg, D., REEVE, J., Benevolenskaya, L. I., Cannata-Andía, J. B., Dequeker, J., Dodenhof, C., Ja, F., Masaryk, P., Pols, H. A. P., et al. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.11.1883 · Cited by 194 · see citing works
Bonadonna, S., Mazziotti, G., Nuzzo, M., Bianchi, A., Fusco, A., Marinis, L. D., & Giustina, A. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050603 · Cited by 187 · see citing works
Self-citationIncidental Vertebral Fractures Discovered With Chest Radiography in the Emergency Department
Majumdar, S. R., Kim, N., Colman, I., Chahal, A. M., Raymond, G. S., Jen, H., Siminoski, K. G., Hanley, D. A., & Rowe, B. H. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.905 · Cited by 182 · see citing works
Tauchmanovà, L., Pivonello, R., Somma, C. D., Rossi, R., Martino, M. D. D., Camera, L., Klain, M., Salvatore, M., Lombardi, G., & Colao, A. (2006) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2005-0582 · Cited by 162 · see citing works
Impact of Somatostatin Analogs on the Heart in Acromegaly: A Metaanalysis
Maison, P., Tropeano, A., Macquin‐Mavier, I., Giustina, A., & Chanson, P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2547 · Cited by 154 · see citing works
Self-citationDiamond, T., Nery, L., & Posen, S. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-7-567 · Cited by 147 · see citing works
Vertebral Fracture Risk With Long-term Corticosteroid Therapy
Naganathan, V., Jones, G., Nash, P. T., Nicholson, G. C., Eisman, J. A., & Sambrook, P. N. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.19.2917 · Cited by 141 · see citing works
Mazziotti, G., Bianchi, A., Bonadonna, S., Nuzzo, M., Cimino, V., Fusco, A., De Marinis, L., & Giustina, A. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060112 · Cited by 141 · see citing works
Self-citationGennari, L., & Bilezikian, J. P. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.008 · Cited by 98 · see citing works
Lindsay, R., Pack, S. E., & Li, Z. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1691-5 · Cited by 97 · see citing works
Gonadal status is an important determinant of bone density in acromegaly
Lesse, Fraser, Farquharson, Hipkin, & Vora (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00349.x · Cited by 90 · see citing works
Diagnosis and treatment of acromegaly complications.
Jaquet, P., & Saveanu, A. (2006) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 88 · see citing works
The European prospective osteoporosis study
REEVE, J. (1996) · Osteoporosis International · doi:10.1007/bf01623758 · Cited by 85 · see citing works
Scillitani, A., Chiodini, I., Carnevale, V., Giannatempo, G. M., Frusciante, V., Villella, M., Pileri, M., Guglielmi, G., Giorgio, A. D., Modoni, S., et al. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.10.1729 · Cited by 74 · see citing works
Ueland, T., Fougner, S. L., Godang, K., Schreiner, T., & Bollerslev, J. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02285 · Cited by 69 · see citing works
Fracture risk is decreased in acromegaly?a potential beneficial effect of growth hormone
Vestergaard, P., & Mosekilde, L. (2004) · Osteoporosis International · doi:10.1007/s00198-003-1531-z · Cited by 67 · see citing works
Bone mineral density in acromegaly: the effect of gender, disease activity and gonadal status
Scillitani, A., Battista, C., Chiodini, I., Carnevale, V., Fusilli, S., Ciccarelli, E., Terzolo, M., Oppizzi, G., Arosio, M., Gasperi, M., et al. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01777.x · Cited by 63 · see citing works
Spinal volumetric trabecular bone mass in acromegalic patients: a longitudinal study
Battista, C., Chiodini, I., Muscarella, S., Guglielmi, G., Mascia, M. L., Carnevale, V., & Scillitani, A. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03322.x · Cited by 60 · see citing works
Colao, A. A. L., Pivonello, R., Scarpa, R., Vallone, G., Ruosi, C., & Lombardi, G. (2001) · CRC Press eBooks · doi:10.3109/9780203214237-191 · Cited by 49 · see citing works
Mazziotti, G., Bianchi, A., Cimino, V., Bonadonna, S., Martini, P. R., Fusco, A., Marinis, L. D., & Giustina, A. (2007) · Pituitary · doi:10.1007/s11102-007-0069-z · Cited by 48 · see citing works
Self-citationMackie, E. J., Trechsel, U., & Bruns, C. (1990) · Development · doi:10.1242/dev.110.4.1233 · Cited by 47 · see citing works
REEVE, J. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.9.1664 · Cited by 41 · see citing works
Patel, M., Arden, N., Masterson, L. M., Phillips, D. I. W., Swaminathan, R., Syddall, H. E., Byrne, C. D., Wood, P. J., Cooper, C. C., & Holt, R. I. G. (2005) · Bone · doi:10.1016/j.bone.2005.06.016 · Cited by 38 · see citing works
Zgliczyński, W., Kochman, M., Misiorowski, W., & Zdunowski, P. (2007) · PubMed · Cited by 31 · see citing works
Differential presentation of cortical and trabecular peripheral bone mineral density in acromegaly.
Jockenhövel, F., Rohrbach, S., Deggerich, S., REINWEIN, D., & Reiners, C. (1996) · PubMed · Cited by 30 · see citing works
GH deficiency in the adult and bone.
Doga, M., Bonadonna, S., Gola, M., Mazziotti, G., Nuzzo, M. D., & Giustina, A. (2005) · PubMed · Cited by 29 · see citing works
Self-citationGrowth hormone predicts bone density in elderly women
Dennison, E. M., Hindmarsh, P. C., Kellingray, S., Fall, C. H. D., & Cooper, C. C. (2003) · Bone · doi:10.1016/s8756-3282(03)00035-8 · Cited by 27 · see citing works
Factors Associated with Bone Metabolism in Acromegalic Patients: Hypogonadism and Female Gender
Tütüncü, N. B., & Erbas, T. A. (2004) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-820913 · Cited by 16 · see citing works
Hypovitaminosis D among unselected medical inpatients and outpatients in Northern Italy
CIGOLINI, M., Miconi, V., Soffiati, G., Fortunato, A., Iagulli, M. P., Lombardi, S., & Targher, G. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02470.x · Cited by 13 · see citing works
Mn, L., Galinsky, D., Fried, Castel, H., Shany, S., & Gazit, D. (1990) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)
Thakker, R. V., Newey, P. J., Walls, G. V., Bilezikian, J. P., Dralle, H., Ebeling, P. R., Melmed, S. K., Sakurai, A., Tonelli, F., & Brandi, M. L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1230 · Cited by 1,473 · see citing works
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., Dinauer, C., Hamilton, J. K., HAY, I. D., Luster, M., et al. (2015) · Thyroid · doi:10.1089/thy.2014.0460 · Cited by 1,252 · see citing works
A Consensus on Criteria for Cure of Acromegaly
Giustina, A., Chanson, P., Bronstein, M. D., Klibanski, A., Lamberts, S. W. J., Casanueva, F. F., Trainer, P. J., Ghigo, E., Ho, K. K. Y., & Melmed, S. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2670 · Cited by 787 · see citing works
Self-citationA Consensus Statement on acromegaly therapeutic outcomes
Melmed, S. K., Bronstein, M. D., Chanson, P., Klibanski, A., Casanueva, F. F., Wass, J. A. H., Strasburger, C. J., Luger, A., Clemmons, D. R., & Giustina, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0058-5 · Cited by 560 · see citing works
Self-citationExpert consensus document: A consensus on the medical treatment of acromegaly
Giustina, A., Chanson, P., Kleinberg, D. L., Bronstein, M. D., Clemmons, D. R., Klibanski, A., van der Lely, A. J., Strasburger, C. J., Lamberts, S. W. J., Ho, K. K. Y., et al. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.21 · Cited by 407 · see citing works
Self-citationColao, A., Grasso, L. F. S., Giustina, A., Melmed, S. K., Chanson, P., Pereira, A. M., & Pivonello, R. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0071-6 · Cited by 397 · see citing works
Self-citationSystemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update
Gadelha, M. R., Kasuki, L., Lim, D. S. T., & Fleseriu, M. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00115 · Cited by 368 · see citing works
A consensus on the diagnosis and treatment of acromegaly complications
Melmed, S. K., Casanueva, F. F., Klibanski, A., Bronstein, M. D., Chanson, P., Lamberts, S. W. J., Strasburger, C. J., Wass, J. A. H., & Giustina, A. (2012) · Pituitary · doi:10.1007/s11102-012-0420-x · Cited by 324 · see citing works
Self-citationEffect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Locatelli, V., & Bianchi, V. E. (2014) · International Journal of Endocrinology · doi:10.1155/2014/235060 · Cited by 318 · see citing works
Katznelson, L. J., Atkinson, J. L. D., Cook, D. M., Ezzat, S., Hamrahian, A. H., & Miller, K. K. (2011) · Endocrine Practice · doi:10.4158/ep.17.s4.1 · Cited by 260 · see citing works
40 YEARS OF IGF1: Insulin-like growth factors: actions on the skeleton
Yakar, S., Werner, H., & Rosen, C. J. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0298 · Cited by 238 · see citing works
Acromegaly incidence, prevalence, complications and long-term prognosis: a nationwide cohort study
Dal, J., Feldt‐Rasmussen, U., Andersen, M., Kristensen, L. Ø., Laurberg, P., Pedersen, L. H., Dekkers, O. M., Sørensen, H. T., & Jørgensen, J. O. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0117 · Cited by 215 · see citing works
Bone Turnover, Bone Mineral Density, and Fracture Risk in Acromegaly: A Meta-Analysis
Mazziotti, G., Biagioli, E. C., Maffezzoni, F., Spinello, M., Serra, V., Maroldi, R., Floriani, I., & Giustina, A. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2937 · Cited by 182 · see citing works
Self-citationMazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works
Self-citationVertebral Fractures in Patients With Acromegaly: A 3-Year Prospective Study
Mazziotti, G., Bianchi, A., Porcelli, T., Mormando, M., Maffezzoni, F., Cristiano, A., Giampietro, A., De Marinis, L., & Giustina, A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-1460 · Cited by 172 · see citing works
Self-citationNew understanding and treatments for osteoporosis
Mazziotti, G., Bilezikian, J. P., CANALIS, E. M., Cocchi, D., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9570-2 · Cited by 151 · see citing works
Self-citationChanson, P., Salenave, S., Kamenický, P., Cazabat, L., & Young, J. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2009.05.010 · Cited by 151 · see citing works
Wassenaar, M. J. E., Biermasz, N. R., Hamdy, N. A. T., Zillikens, M. C., van Meurs, J. B. J., Rivadeneira, F., Hofman, A., Uitterlinden, A. G., Stokkel, M. P. M., Roelfsema, F., et al. (2011) · European Journal of Endocrinology · doi:10.1530/eje-10-1005 · Cited by 144 · see citing works
Current and Emerging Aspects of Diabetes Mellitus in Acromegaly
Frara, S., Maffezzoni, F., Mazziotti, G., & Giustina, A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.04.014 · Cited by 138 · see citing works
Self-citationClinical Manifestations and Diagnosis of Acromegaly
Lugo, G., Pena, L., & Cordido, F. (2012) · International Journal of Endocrinology · doi:10.1155/2012/540398 · Cited by 129 · see citing works
Claessen, K. M. J. A., Kroon, H. M., Pereira, A. M., Appelman-Dijkstra, N. M., Verstegen, M. J., Kloppenburg, M., Hamdy, N. A. T., & Biermasz, N. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2695 · Cited by 111 · see citing works
Vertebral fractures in males with prolactinoma
Mazziotti, G., Porcelli, T., Mormando, M., De Menis, E., Bianchi, A., Mejia, C., Mancini, T., De Marinis, L., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9462-5 · Cited by 109 · see citing works
Self-citationBone and Joint Disorders in Acromegaly
Claessen, K. M. J. A., Mazziotti, G., Biermasz, N. R., & Giustina, A. (2015) · Neuroendocrinology · doi:10.1159/000375450 · Cited by 96 · see citing works
Self-citationPegvisomant in acromegaly: an update
Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A. A. L., Marinis, L. D., Menis, E. D., Uberti, E. C. D., Giorgino, F., Grottoli, S., et al. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0614-1 · Cited by 85 · see citing works
Self-citationVertebral fractures in males with type 2 diabetes treated with rosiglitazone
Mancini, T., Mazziotti, G., Doga, M., Carpinteri, R., Simetovic, N., Vescovi, P. P., & Giustina, A. (2009) · Bone · doi:10.1016/j.bone.2009.06.006 · Cited by 84 · see citing works
Self-citationInsulin Resistance in Patients With Acromegaly
Vila, G., Jørgensen, J. O. L., Luger, A., & Stalla, G. K. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00509 · Cited by 81 · see citing works
Effects of Growth Hormone on Bone
Tritos, N. A., & Klibanski, A. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.10.008 · Cited by 77 · see citing works
Maffezzoni, F., Maddalo, M., Frara, S., Mezzone, M., Zorza, I., Baruffaldi, F., Doglietto, F., Mazziotti, G., Maroldi, R., & Giustina, A. (2016) · Endocrine · doi:10.1007/s12020-016-1078-3 · Cited by 75 · see citing works
Self-citationBone histomorphometry in acromegaly patients with fragility vertebral fractures
Carbonare, L. D., Micheletti, V., Cosaro, E., Valenti, M. T., Mottes, M., Francia, G., & Davì, M. V. (2017) · Pituitary · doi:10.1007/s11102-017-0847-1 · Cited by 72 · see citing works
Influence of diabetes mellitus on vertebral fractures in men with acromegaly
Mazziotti, G., Gola, M., Bianchi, A., Porcelli, T., Giampietro, A., Cimino, V., Doga, M., Gazzaruso, C., Marinis, L. D., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9486-x · Cited by 69 · see citing works
Self-citationMazziotti, G., Porcelli, T., Bianchi, A., Cimino, V, Patelli, I., Mejia, C., Fusco, A., Giampietro, A., De Marinis, L., & Giustina, A. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0125 · Cited by 68 · see citing works
Self-citationMANAGEMENT OF ENDOCRINE DISEASE: Does gender matter in the management of acromegaly?
Lenders, N. F., McCormack, A. I., & Ho, K. K. Y. (2020) · European Journal of Endocrinology · doi:10.1530/eje-19-1023 · Cited by 65 · see citing works
Parathyroid hormone pulsatility: physiological and clinical aspects
Chiavistelli, S., Giustina, A., & Mazziotti, G. (2015) · Bone Research · doi:10.1038/boneres.2014.49 · Cited by 64 · see citing works
Self-citationChiloiro, S., Giampietro, A., Frara, S., Bima, C., Donfrancesco, F., Fleseriu, C. M., Pontecorvi, A., Giustina, A., Fleseriu, M., Marinis, L. D., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz054 · Cited by 64 · see citing works
Self-citationA Link between Bone Mineral Density and Serum Adiponectin and Visfatin Levels in Acromegaly
Sucunza, N., Barahona, M. J., Resmini, E., Fernández‐Real, J. M., Ricart, W., Farrerons, J., Rodrı́guez-Espinosa, J., Marin, A.-M., Puig, T., & Webb, S. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0474 · Cited by 62 · see citing works
The risks of overlooking the diagnosis of secreting pituitary adenomas
Brue, T. C., & Castinetti, F. (2016) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-016-0516-x · Cited by 61 · see citing works
High prevalence of radiological vertebral fractures in HIV-infected males
Torti, C., Mazziotti, G., Soldini, P., Focà, E., Maroldi, R., Gotti, D., Carosi, G., & Giustina, A. (2011) · Endocrine · doi:10.1007/s12020-011-9586-7 · Cited by 60 · see citing works
Self-citationTreatment of acromegaly increases BMD but reduces trabecular bone score: a longitudinal study
Godang, K., Olarescu, N. C., Bollerslev, J., & Heck, A. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0340 · Cited by 60 · see citing works
Malgo, F., Hamdy, N. A. T., Rabelink, T. J., Kroon, H. M. J. A., Claessen, K. M. J. A., Pereira, A. M., Biermasz, N. R., & Appelman‐Dijkstra, N. M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-0808 · Cited by 60 · see citing works
Prevalence of osteoporosis and vertebral fractures in acromegalic patients.
Padova, G., Borzì, G., Incorvaia, L., Siciliano, G., Migliorino, V., Vetri, M. G., & Tita, P. (2011) · PubMed Central · Cited by 60 · see citing works
di Filippo, L., Doga, M., Resmini, E., & Giustina, A. (2020) · Pituitary · doi:10.1007/s11102-020-01041-3 · Cited by 59 · see citing works
Self-citationMazziotti, G., Maffezzoni, F., Frara, S., & Giustina, A. (2016) · Pituitary · doi:10.1007/s11102-016-0758-6 · Cited by 54 · see citing works
Self-citationVertebral Fracture Assessment in Acromegaly
Madeira, M., Neto, L. V., Torres, C. H., de Mendonça, L. M. C., Gadelha, M. R., & Farias, M. L. F. (2012) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2012.06.002 · Cited by 53 · see citing works
Skeletal effects of growth hormone and insulin-like growth factor-I therapy
Lindsey, R. C., & Mohan, S. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.017 · Cited by 53 · see citing works
High prevalence of radiological vertebral fractures in adult patients with Ehlers–Danlos syndrome
Mazziotti, G., Dordoni, C., Doga, M., Galderisi, F., Venturini, M., Calzavara‐Pinton, P., Maroldi, R., Giustina, A., & Colombi, M. (2015) · Bone · doi:10.1016/j.bone.2015.12.007 · Cited by 50 · see citing works
Self-citationChanson, P., Salenave, S., & Kamenický, P. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00014-9 · Cited by 48 · see citing works
Bone microarchitecture and estimated bone strength in men with active acromegaly
Silva, P. P. B., Amlashi, F. G., Yu, E. W.-Y., Pulaski, K., Gerweck, A. V., Fazeli, P. K., Lawson, E. A., Nachtigall, L. B., Biller, B. M. K., Miller, K. K., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0468 · Cited by 48 · see citing works
Mazziotti, G., Chiavistelli, S., & Giustina, A. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2014.10.014 · Cited by 46 · see citing works
Self-citationChiloiro, S., Mormando, M., Bianchi, A., Giampietro, A., Milardi, D., Bima, C., Grande, G., Formenti, A. M., Mazziotti, G., Pontecorvi, A., et al. (2017) · Endocrine · doi:10.1007/s12020-017-1391-5 · Cited by 45 · see citing works
Self-citationChiloiro, S., Mazziotti, G., Giampietro, A., Bianchi, A., Frara, S., Mormando, M., Pontecorvi, A., Giustina, A., & Marinis, L. D. (2018) · Pituitary · doi:10.1007/s11102-018-0873-7 · Cited by 45 · see citing works
Self-citationFrara, S., Uygur, M. M., di Filippo, L., Doga, M., Losa, M., Santoro, S., Mortini, P., & Giustina, A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac183 · Cited by 43 · see citing works
Self-citationAcromegaly and Bone: An Update
Giustina, A. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.601 · Cited by 42 · see citing works
Self-citationMazziotti, G., Battista, C., Maffezzoni, F., Chiloiro, S., Ferrante, E., Prencipe, N., Grasso, L. F. S., Gatto, F., Olivetti, R., Arosio, M., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa363 · Cited by 41 · see citing works
Self-citationOctreotide for acromegaly treatment: a reappraisal
Giustina, A., Karamouzis, I., Patelli, I., & Mazziotti, G. (2013) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2013.847090 · Cited by 40 · see citing works
Self-citationThe Modern Criteria for Medical Management of Acromegaly
Frara, S., Maffezzoni, F., Mazziotti, G., & Giustina, A. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.10.015 · Cited by 40 · see citing works
Self-citationWassenaar, M. J. E., Biermasz, N. R., Pereira, A. M., van der Klaauw, A. A., Smit, J. W. A., Roelfsema, F., van der Straaten, T., Cazemier, M., Hommes, D. W., Kroon, H. M. J. A., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1172 · Cited by 38 · see citing works
FRAX score in acromegaly: does it tell the whole story?
Brzana, J. A., Yedinak, C. G., Hameed, N., & Fleseriu, M. (2013) · Clinical Endocrinology · doi:10.1111/cen.12262 · Cited by 35 · see citing works
Risk of vertebral fractures in hypoparathyroidism
Formenti, A. M., Tecilazich, F., Giubbini, R., & Giustina, A. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09507-x · Cited by 35 · see citing works
Self-citationGH receptor isoforms and skeletal fragility in acromegaly
Mormando, M., Nasto, L. A., Bianchi, A., Mazziotti, G., Giampietro, A., Pola, E., Pontecorvi, A., Giustina, A., & Marinis, L. D. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0205 · Cited by 34 · see citing works
Self-citationGrowth hormone deficiency in treated acromegaly
Mazziotti, G., Marzullo, P., Doga, M., Aimaretti, G., & Giustina, A. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2014.10.005 · Cited by 33 · see citing works
Self-citationAnthony, J. R., & Ioachimescu, A. G. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000109 · Cited by 33 · see citing works
Trabecular bone score and bone mineral density in patients with long‐term controlled acromegaly
Calatayud, M., Martín, L. P., Librizzi, M. S., Lora, D., Mendez, V. G., Aramendi, M., Diaz‐Guerra, G. M., & Hawkins, F. G. (2021) · Clinical Endocrinology · doi:10.1111/cen.14439 · Cited by 32 · see citing works
Cellini, M., Biamonte, E., Mazza, M., Trenti, N., Ragucci, P., Milani, D., Ferrante, E., Rossini, Z., Lavezzi, E., Sala, E., et al. (2020) · Neuroendocrinology · doi:10.1159/000511811 · Cited by 31 · see citing works
Self-citationBioletto, F., Barale, M., Prencipe, N., Berton, A. M., Parasiliti‐Caprino, M., Gasco, V., Ghigo, E., Massimo, P., & Grottoli, S. (2022) · Neuroendocrinology · doi:10.1159/000528199 · Cited by 31 · see citing works
High Prevalence of Radiological Vertebral Fractures in Patients With TSH-Secreting Pituitary Adenoma
Frara, S., Losa, M., Doga, M., Formenti, A. M., Mortini, P., Mazziotti, G., & Giustina, A. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00091 · Cited by 31 · see citing works
Self-citationVecchi, V. L., Soresi, M., Giannitrapani, L., Mazzola, G. C., Sala, S. L., Tramuto, F., Caruso, G., Colomba, C., Mansueto, P., Madonia, S., et al. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-192 · Cited by 30 · see citing works
Vena, W., Pizzocaro, A., Indirli, R., Amer, M., Maffezzoni, F., Delbarba, A., Leonardi, L., Balzarini, L., Ulivieri, F. M., Ferlin, A., et al. (2020) · Andrology · doi:10.1111/andr.12841 · Cited by 30 · see citing works
Self-citationSilva, P. P. B., Pereira, R. M. R., Takayama, L., Borba, C. G., Duarte, F. H. G., Trarbach, E. B., Martin, R. M., Bronstein, M. D., Tritos, N. A., & Jallad, R. S. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab260 · Cited by 30 · see citing works
Lim, S., Marenzana, M., Hopkinson, M., List, E. O., Kopchick, J. J., Pereira, M., Javaheri, B., Roux, J. P., Chavassieux, P., Korbonits, M., et al. (2015) · Endocrinology · doi:10.1210/en.2014-1572 · Cited by 29 · see citing works
Prevalence of vertebral fractures and serum sclerostin levels in acromegaly
Uygur, M. M., Yazıcı, D., Buğdaycı, O., & Yavuz, D. G. (2021) · Endocrine · doi:10.1007/s12020-021-02751-9 · Cited by 28 · see citing works
Pituitary Disorders and Osteoporosis
Bolanowski, M., Halupczok, J., & Jawiarczyk-Przybyłowska, A. (2015) · International Journal of Endocrinology · doi:10.1155/2015/206853 · Cited by 27 · see citing works
Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis
de Moura, C. R., Lopes, S. G. D. C., & Monteiro, A. M. (2022) · Pituitary · doi:10.1007/s11102-022-01256-6 · Cited by 25 · see citing works
Vena, W., Carrone, F., Delbarba, A., Akpojiyovbi, O., Pezzaioli, L. C., Facondo, P., Cappelli, C., Leonardi, L., Balzarini, L., Farina, D., et al. (2022) · Journal of Endocrinological Investigation · doi:10.1007/s40618-022-01901-8 · Cited by 25 · see citing works
Self-citationVitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?
Mazziotti, G., Maffezzoni, F., & Giustina, A. (2016) · Endocrine · doi:10.1007/s12020-016-0890-0 · Cited by 24 · see citing works
Self-citationGrowth hormone deficiency in treated acromegaly and active Cushing's syndrome
Formenti, A. M., Maffezzoni, F., Doga, M., Mazziotti, G., & Giustina, A. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.03.002 · Cited by 24 · see citing works
Self-citationAcromegalic arthropathy: current perspectives
Romijn, J. A. (2012) · Endocrine · doi:10.1007/s12020-012-9781-1 · Cited by 21 · see citing works
Porcelli, T., Gotti, D., Cristiano, A., Maffezzoni, F., Mazziotti, G., Focà, E., Castelli, F., Giustina, A., & Quirós-Roldán, E. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2760-z · Cited by 20 · see citing works
Self-citationThe acromegalic spine: fractures, deformities and spinopelvic balance
Oliveira, B. D. A., de Araújo, B. M. F., dos Santos, T. M., Ongaratti, B. R., Leães, C. G. S., Ferreira, N. P., Pereira‐Lima, J. F. S., & Oliveira, M. D. C. (2019) · Pituitary · doi:10.1007/s11102-019-00991-7 · Cited by 20 · see citing works
Is every joint symptom related to acromegaly?
Örük, G., Tarhan, E. F., Argın, M., & Özmen, M. (2012) · Endocrine · doi:10.1007/s12020-012-9770-4 · Cited by 20 · see citing works
Lorenzo, J. A., CANALIS, E. M., & Raisz, L. G. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00029-8 · Cited by 20 · see citing works
Growth hormone receptor isoforms and fracture risk in adult‐onset growth hormone‐deficient patients
Mormando, M., Chiloiro, S., Bianchi, A., Giampietro, A., Angelini, F., Tartaglione, L., Nasto, L. A., Milardi, D., Formenti, A. M., Giustina, A., et al. (2016) · Clinical Endocrinology · doi:10.1111/cen.13161 · Cited by 19 · see citing works
Self-citationSpinal deformity index in patients with type 2 diabetes
Somma, C. D., Rubino, M., Faggiano, A., Vuolo, L., Contaldi, P., Tafuto, N., Andretti, M., Savastano, S., & Colao, A. A. L. (2012) · Endocrine · doi:10.1007/s12020-012-9848-z · Cited by 19 · see citing works
Valassi, E., Crespo, I., Malouf, J., Llauger, J., Aulinas, A., Marín, A. M., Biagetti, B., & Webb, S. M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0931 · Cited by 19 · see citing works
Bone mineral density and vitamin D levels in erythropoietic protoporphyria
Miguel, G. A., Garrido-Astray, M. C., de Salamanca, R. E., Martínez, G., & Hawkins, F. G. (2013) · Endocrine · doi:10.1007/s12020-013-9934-x · Cited by 18 · see citing works
Dalla Grana, E., Rigo, F., Lanzafame, M., Lattuada, E., Suardi, S., Mottes, M., Valenti, M. T., & Dalle Carbonare, L. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00302 · Cited by 17 · see citing works
Stephens, K., Rubinsztain, L., Payan, J. M., Rentsch, C., Rimland, D., & Tangpricha, V. (2015) · Endocrine Practice · doi:10.4158/ep15958.or · Cited by 17 · see citing works
Craniofacial Morphology in Children with Growth Hormone Deficiency and Turner Syndrome
Wojcik, D. M., & Beń‐Skowronek, I. (2020) · Diagnostics · doi:10.3390/diagnostics10020088 · Cited by 16 · see citing works
Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study
Kwon, H., Han, K., Kim, B., Moon, S. J., Park, S. E., Rhee, E., & Lee, W. (2023) · Osteoporosis International · doi:10.1007/s00198-023-06800-z · Cited by 15 · see citing works
Understanding the effect of acromegaly on the human skeleton
Bima, C., Chiloiro, S., Mormando, M., Piacentini, S., Bracaccia, E., Giampietro, A., Tartaglione, L., Bianchi, A., & Marinis, L. D. (2016) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2016.1179108 · Cited by 15 · see citing works
Self-citationPlard, C., Hochman, C., Hadjadj, S., Goff, B. L., Maugars, Y., Cariou, B., Drui, D., & Guillot, P. (2020) · Joint Bone Spine · doi:10.1016/j.jbspin.2020.04.020 · Cited by 15 · see citing works
Kuker, A. P., Agarwal, S., Shane, E. J., Cohen, A., Nickolas, T. L., Stein, E. M., Reid, T. J., Hans, D. B., Cremers, S., Bruce, J. N., et al. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad121 · Cited by 14 · see citing works
Skeletal complications in acromegaly
Wydra, A., Stelmachowska‐Banaś, M., & Czajka-Oraniec, I. (2023) · Reumatologia/Rheumatology · doi:10.5114/reum/169918 · Cited by 12 · see citing works
Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Korea
Kim, J., Hong, N., Choi, J., Moon, J. H., Kim, E. H., Lee, E. J., Kim, S. G., & Ku, C. R. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1782 · Cited by 12 · see citing works
Reyes‐García, R., García‐Martin, A., Varsavsky, M., Rozas-Moreno, P., Berdonces, M. C., Luque-Fernández, I., Sáez, J. M. G., Vidal‐Casariego, A., Muñoz, M. R., Iglesias, S. G., et al. (2015) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2015.01.011 · Cited by 12 · see citing works
Jawiarczyk-Przybyłowska, A., Halupczok-Żyła, J., Kolačkov, K., Gojny, Ł., Zembska, A., & Bolanowski, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00643 · Cited by 12 · see citing works
Use of GLP-1 mimetic in type 2 diabetes mellitus: is it the end of fragility fractures?
Mabilleau, G. (2014) · Endocrine · doi:10.1007/s12020-014-0461-1 · Cited by 12 · see citing works
Hong, S., Han, K., & Park, C. (2025) · Endocrinology and Metabolism · doi:10.3803/enm.2024.2285 · Cited by 10 · see citing works
Update on vertebral fractures in pituitary diseases: from research to clinical practice
Carrone, F., Ariano, S. A., Piccini, S., Milani, D., Mirani, M., Balzarini, L., Lania, A. G., & Mazziotti, G. (2021) · HORMONES · doi:10.1007/s42000-021-00275-5 · Cited by 10 · see citing works
Self-citationNazzari, E., Casabella, A., Paolino, S., Campana, C., Corica, G., Nista, F., Milioto, A., Tagliafico, A. S., Albertelli, M., Boschetti, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11216374 · Cited by 10 · see citing works
Vitamin D in pituitary driven osteopathies
Chiloiro, S., Costanza, F., Riccardi, E., Giampietro, A., Marinis, L. D., Bianchi, A., Pontecorvi, A., & Giustina, A. (2024) · Pituitary · doi:10.1007/s11102-024-01439-3 · Cited by 10 · see citing works
Self-citation
- Authors
- Mazziotti, G., Bianchi, A., Bonadonna, S., Cimino, V., Patelli, I., Fusco, A., Pontecorvi, A., De Marinis, L., & Giustina, A.
- Affiliations
- University of Brescia (IT)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Giustina, Andrea
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-12
- Volume
- 93
- Issue
- 12
- Pages
- 4649-4655
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979553864
- Cited by
- 169
- References
- 48
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 12 · 2015: 12 · 2014: 13 · 2013: 6 · 2012: 8
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- acromegaly, vertebral fractures, osteoporosis, men, bone mineral density, insulin-like growth factor I, hypogonadism, disease duration, fracture risk factors
- MeSH terms
- Acromegaly, Adolescent, Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Hip, Humans, Hypogonadism, Male, Middle Aged, Osteoporosis, Pituitary Hormones, Spinal Injuries, Absorptiometry, Photon, Bone Density, Logistic Models, Odds Ratio, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
