Relationship between obstructive sleep apnea syndrome and thyroid diseases
Abstract
Obstructive sleep apnea syndrome (OSAS) is a widespread disorder characterized by recurrent, partial, or complete episodes of apnea due to upper airway tract obstruction during sleep. OSAS frequency is likely to increase in hypothyroidism because of obesity, macroglossia, dysfunctional upper respiratory tractus (URT) musculature, deposition of mucopolysaccharides in URT tissues, and decreased ventilatory control. This study examines the relationship between OSAS and thyroid disease in OSAS subjects. This study includes 150 polysomnographically diagnosed OSAS patients (50 mild, 50 moderate, 50 severe OSAS cases) treated at Endocrinology and Metabolism Department of Ankara Numune Training and Research Hospital between January 2010 and May 2011 and 32 non-OSAS control subjects. All patients were given serum TSH, free T3 (fT3), free T4 (fT4), anti thyroid peroxidase (Anti-TPO), and anti-thyroglobulin (anti-TG) tests, as well as thyroid ultrasounds. We did not find any difference in prevalence of hypothyroidism, numbers of nodules and parenchyma heterogenicity determined by ultrasound, between OSAS subgroups and controls (p > 0,05). In this study, functional and ultrasonographic examination of the thyroid gland did not reveal any relationship between OSAS and thyroid disease. We believe hence that long-term follow-up studies can establish the possible significance of routine evaluation of OSAS patients for thyroid disease.
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Mete et al. did not find any difference in numbers of nodules between OSAS subgroups and controls.
“The authors did not find any difference in prevalence of hypothyroidism, numbers of nodules, and parenchyma heterogenecity determined by ultrasound, between OSAS subgroups and controls.”
From Sleep apnea syndrome and hypothyroidism (2013) · cites this paper as [9]
Mete et al. did not find any difference in prevalence of hypothyroidism (including subclinical and overt) between OSAS patients and controls.
“The authors did not find any difference in prevalence of hypothyroidism, numbers of nodules, and parenchyma heterogenecity determined by ultrasound, between OSAS subgroups and controls.”
From Sleep apnea syndrome and hypothyroidism (2013) · cites this paper as [9]
Mete et al. did not find any difference in parenchyma heterogeneity between OSAS subgroups and controls.
“The authors did not find any difference in prevalence of hypothyroidism, numbers of nodules, and parenchyma heterogenecity determined by ultrasound, between OSAS subgroups and controls.”
From Sleep apnea syndrome and hypothyroidism (2013) · cites this paper as [9]
Mete et al. assessed 150 patients with polysomnographically diagnosed OSA and showed no significant association between OSA severity and thyroid hormone levels.
“Similarly, Mete et al. (14) assessed 150 patients with polysomnographically diagnosed OSA (50 mild, 50 moderate, and 50 severe OSA cases) and showed no significant association between OSA severity and thyroid hormone levels.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [14]
Mete et al. described that hypothyroidism could alter ventilatory drive and respiratory muscle function.
“Hypothyroidism also could alter ventilatory drive and respiratory muscle function.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [14]
Mete et al. described that some patients with hypothyroidism may have increased thyroid size that causes or worsens upper airway obstruction.
“For example, some patients with hypothyroidism may have increased thyroid size that causes or worsens upper airway obstruction.”
From Thyroid Dysfunction and Sleep Disorders (2021) · cites this paper as [14]
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References 19 · Cited by 46
- Authors
- Mete, T., Yalcin, Y., Berker, D., Ciftci, B., Guven Firat, S., Topaloglu, O., Cinar Yavuz, H., & Guler, S.
- Affiliations
- Ministry of Health (TR)
- ORCID
- Berker, Dilek
- Venue
- Endocrine
- Published
- 2013-04-06
- Volume
- 44
- Issue
- 3
- Pages
- 723-728
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2404565756
- Cited by
- 46
- References
- 19
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 10 · 2015: 1 · 2014: 2 · 2013: 4
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- obstructive sleep apnea, thyroid dysfunction, hypothyroidism, thyroid nodules, thyroid ultrasound, thyroid function tests, thyroid peroxidase antibodies, thyroglobulin antibodies, upper airway obstruction
- MeSH terms
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Thyroid Diseases, Thyroid Function Tests, Polysomnography, Sleep Apnea, Obstructive
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