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Cited by 29Adrenal Hormones and DisordersStress Responses and CortisolHormonal Regulation and Hypertension

Longitudinal AddiQoL scores may identify higher risk for adrenal crises in Addison’s disease

Meyer, Gesine, Koch, Maike, Herrmann, Eva, Bojunga, Jörg, Badenhoop, Klaus·2018·Endocrine
DOI 10.1007/s12020-017-1513-0
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Abstract

Purpose Several studies have shown a reduced quality of life (QoL) in patients with Addison's disease (AD), but investigations of QoL over a long-term course are lacking. Adrenal crises (AC) are life-threatening complications in AD. The purpose of this prospective study was to test whether the repeated use of QoL-questionnaires can detect prodromal periods of an AC. Methods 110 patients with AD were asked to complete the disease specific-QoL questionnaire AddiQoL and a short questionnaire about adverse events once monthly over a period of ten months. AC was defined if at least two of the following symptoms were reported: (a) hypotension, (b) nausea or vomiting, (c) severe fatigue, (d) documented hyponatremia, hyperkalemia, or hypoglycemia, and subsequent parenteral glucocorticoid administration was carried out. Results Prevalence of AC was 10.9/100 patient years. AddiQoL scores in patients with AC showed a trend (p = 0,08) to a wider fluctuation over time. Subjective precrises not meeting the criteria for AC were reported by 31 patients who had significantly lower AddiQoL scores (p = 0,018). Conclusions These are the first data showing the course of QoL during a period of ten months in patients with AD. Incidence of AC exceeds previous data. Our data show, that subjective precrises in AD associate with lower QoL. AC, as well as precrises affect intraindividual AddiQol-scores over time with a trend to a stronger fluctuation. Longitudinal AddiQol scores and self-reporting of pr…

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Crossref · 10.1007/s12020-017-1513-0

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  • The subjective pre-crisis phase, requiring an increased dose of hydrocortisone replacement, was associated with lower QoL scores.

    “The subjective pre-crises phase, requiring an increased dose of hydrocortisone replacement, was associated with a lower QoL scores.”

    From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [71]

  • In a prospective study of 110 patients with Addison's disease followed monthly for 10 months, those with adrenal crisis (prevalence 10.9/100 patient years) had a wider fluctuation in QoL over time.

    “They included 110 patients with Addison’s disease who completed the disease-specific AddiQoL and another short questionnaire about adverse events once a month over a period of 10 months. The authors found that those with adrenal crisis (prevalence 10.9/100 patient years in this study) had a wider fluctuation in QoL over time.”

    From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [71]

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Authors
Meyer, G., Koch, M., Herrmann, E., Bojunga, J., & Badenhoop, K.
Affiliations
  • University Hospital Frankfurt (DE)
  • Goethe University Frankfurt (DE)
Corresponding author
Meyer, Gesine
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2018-01-31
Volume
60
Issue
2
Pages
355-361
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
DOI
10.1007/s12020-017-1513-0
OpenAlex
W2789806465
Cited by
29
References
6
Citations by year
2026: 6 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 2
FWCI
2.50
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Funders
EUADRENAL (2008-201167)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
Addison's disease, adrenal crisis, quality of life, risk prediction, adrenal insufficiency, patient-reported outcomes, hyponatremia, hypoglycemia
MeSH terms
Symptom Flare Up, Addison Disease, Adult, Aged, Female, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Quality of Life, Young Adult, Prodromal Symptoms

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