The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Postmortem toxicology
Abstract
Results from toxicological analyses in death investigations are used to determine whether foreign substances were a cause of death, whether they contributed to death, or whether they caused impairment. Drug concentrations are likely to change during pre-terminal stages due to altered pharmacokinetics, to treatment during resuscitation or in the intensive care unit, to concomitant illness or to the presence of drug tolerance. The potential for postmortem changes must be considered in all but a few drugs. Formation of new entities as well as degradation of drugs may occur, especially in putrefied corpses; in addition, body fluids and tissues may be severely affected by autolysis and putrefaction. Specimens should be selected based on individual case history and on their availability. Analytical procedures should be performed in accordance with a proper quality assurance program for toxicological investigations. Problems are most likely to occur during the isolation and identification of a drug. Interpretation of analytical results is often limited by the inadequate information provided in a particular case.
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Metadata
- Authors
- Skopp, G.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Skopp, Gisela
- ORCID
- Skopp, Gisela
- Venue
- Forensic Science, Medicine, and Pathology
- Published
- 2010-03-04
- Volume
- 6
- Issue
- 4
- Pages
- 314-325
- ISSN
- 1547-769X (ISSN-L)
- 1556-2891
- OpenAlex
- W4240389001
- Semantic Scholar
- b995434b824e829ec5fc3e4adb7e2415f36efd0f
- Cited by
- 176
- References
- 16
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 13 · 2020: 14 · 2019: 6 · 2018: 12 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 7 · 2013: 15 · 2012: 7
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Forensic Science Medicine and Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Autopsy Techniques and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Historical and Scientific Studies
- Keywords
- postmortem toxicology, postmortem changes, drug degradation, putrefaction, autolysis, pharmacokinetics, drug tolerance, specimen selection, death investigation, drug identification
- MeSH terms
- Autopsy, Body Fluids, Cause of Death, Drug Therapy, Humans, Pharmacokinetics, Poisoning, Postmortem Changes, Specimen Handling, Reproducibility of Results, Substance Abuse Detection, Artifacts, Substance-Related Disorders, Forensic Toxicology
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