CoChat
Sign Up
Cited by 15Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchElectrolyte and hormonal disorders

Incidence and Effect of Diabetes Insipidus in the Acute Care of Patients with Severe Traumatic Brain Injury

Gempeler, Andrés, Orrego-González, Eduardo, Hernandez-Casanas, Andrés, Castro, Andrés M., Aristizabal-Mayor, Juan D., Mejia-Mantilla, Jorge H.·2020·Neurocritical Care
DOI 10.1007/s12028-020-00955-x
Open this paper in CoChat — free account

Abstract

Background Literature on diabetes insipidus (DI) after severe traumatic brain injury (TBI) is scarce. Some studies have reported varying frequencies of DI and have showed its association with increased mortality, suggesting it as a marker of poor outcome. This knowledge gap in the acute care consequences of DI in severe TBI patients led us to conceive this study, aimed at identifying risk factors and quantifying the effect of DI on short-term functional outcomes and mortality.Methods We assembled a historic cohort of adult patients with severe TBI (Glasgow Coma Scale ≤ 8) admitted to the intensive care unit (ICU) of a tertiary-care university hospital over a 6-year period. Basic demographic characteristics, clinical information, imaging findings, and laboratory results were collected. We used logistic regression models to assess potential risk factors for the development of DI, and the association of this condition with death and unfavorable functional outcomes [modified Rankin scale (mRS)] at hospital discharge.Results A total of 317 patients were included in the study. The frequency of DI was 14.82%, and it presented at a median of 2 days (IQR 1-3) after ICU admission. Severity according to the Abbreviated Injury Scale (AIS) score of the head, intracerebral hemorrhage, subdural hematoma, and skull base fracture was suggested as risk factors for DI. Diagnosis of DI was independently associated death (OR 4.34, CI 95% 1.92-10.11, p = 0.0005) and unfavorable outcome (modified Rankin Scale = 4-6) at discharge (OR 7.38; CI 95% 2.15-37.21, p = 0.0047).Conclusions Diabetes insipidus is a frequent and early complication in patients with severe TBI in the ICU and is strongly associated with increased mortality and poor short-term outcomes. We provide clinically useful risk factors that will help detect DI early to improve prognosis and therapy of patients with severe TBI.

Integrity signals

Registry

Crossref · 10.1007/s12028-020-00955-x

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Central DI/AVP-D has been described in 14-26% of patients in the acute period after TBI.

    “Central DI, or arginine vasopressin deficiency (AVP-D), has been described in 14-26% of patients in the acute period after TBI [12-14].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [13]

  • SIADH has been reported in 2.5-14% of post-TBI patients in the acute period.

    “SIADH has been reported in recent decades to appear in 2.5-14% of post-TBI patients in the acute period [1, 13, 14]”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [13]

  • Central DI/AVP-D is associated with mortality after TBI.

    “a number of studies have reported that central DI/AVP-D is associated with mortality [3, 9, 12, 13].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [13]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Gempeler, A., Orrego-González, E., Hernandez-Casanas, A., Castro, A. M., Aristizabal-Mayor, J. D., & Mejia-Mantilla, J. H.
Affiliations
  • Fundación Valle del Lili (CO)
  • Universidad Icesi (CO)
ORCID
Venue
Neurocritical Care
Publisher
Springer Science and Business Media LLC
Published
2020-03-23
Volume
33
Issue
3
Pages
718-724
ISSN
  • 1541-6933 (ISSN-L)
  • 1556-0961
DOI
10.1007/s12028-020-00955-x
OpenAlex
W3012898375
Cited by
15
References
29
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurocritical Care (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fundación Valle del Lili
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
Keywords
diabetes insipidus, severe traumatic brain injury, risk factors, mortality, functional outcome, modified Rankin Scale, intracerebral hemorrhage, subdural hematoma, skull base fracture, intensive care unit, post-traumatic complications
MeSH terms
Brain Injuries, Traumatic, Adult, Diabetes Insipidus, Diabetes Mellitus, Humans, Retrospective Studies, Glasgow Coma Scale, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review