CHI3L2 Expression Levels Are Correlated with AIF1, PECAM1, and CALB1 in the Brains of Alzheimer’s Disease Patients
Abstract
Alzheimer's disease (AD) represents one of the main forms of dementia that afflicts our society. The expression of several genes has been associated with disease development. Despite this, the number of genes known to be capable of discriminating between AD patients according to sex remains deficient. In our study, we performed a transcriptomes meta-analysis on a large court of brains of healthy control subjects (n = 2139) (NDHC) and brains of AD patients (n = 1170). Our aim was to verify the brain expression levels of CHI3L2 and its correlation with genes associated with microglia-mediated neuroinflammation (IBA1), alteration of the blood-brain barrier (PECAM1), and neuronal damage (CALB1). We showed that the CHI3L2, IBA1, PECAM1, and CALB1 expression levels were modulated in the brains of patients with AD compared to NDHC subjects. Furthermore, both in NDHC and in AD patient's brains, the CHI3L2 expression levels were directly correlated with IBA1 and PECAM1 and inversely with CALB1. Additionally, the expression levels of CHI3L2, PECAM1, and CALB1 but not of IBA1 were sex-depended. By stratifying the samples according to age and sex, correlation differences emerged between the expression levels of CHI3L2, IBA1, PECAM1, and CALB1 and the age of NDHC subjects and AD patients. CHI3L2 represents a promising gene potentially involved in the key processes underlying Alzheimer's disease. Its expression in the brains of sex-conditioned AD patients opens up new possible sex therapeu…
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CHI3L2 expression notably increases in the brains of patients with AD.
“The eRNA ENSR00000011444 putatively regulates Chitinase-3-like protein 2 (CHI3L2), whose expression notably increases in the brains of patients with AD and may contribute to AD pathogenesis through neuroinflammatory processes (Fig. 3D) (50, 51).”
From Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains (2025) · cites this paper as [50]
CHI3L2 may contribute to AD pathogenesis through neuroinflammatory processes.
“The eRNA ENSR00000011444 putatively regulates Chitinase-3-like protein 2 (CHI3L2), whose expression notably increases in the brains of patients with AD and may contribute to AD pathogenesis through neuroinflammatory processes (Fig. 3D) (50, 51).”
From Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains (2025) · cites this paper as [50]
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References 85 · Cited by 26
- Authors
- Sanfilippo, C., Castrogiovanni, P., Imbesi, R., & Di Rosa, M.
- Affiliations
- Centro Neurolesi Bonino Pulejo (IT)
- University of Catania (IT)
- Venue
- Journal of Molecular Neuroscience
- Published
- 2020-07-23
- Volume
- 70
- Issue
- 10
- Pages
- 1598-1610
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W3044900045
- Cited by
- 26
- References
- 85
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 1
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, CHI3L2, CD31, calbindin-D28k, Iba1, blood-brain barrier, neuronal injury, sex differences, gene expression, brain transcriptome
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Calcium-Binding Proteins, Chitinases, Female, Humans, Male, Microfilament Proteins, Platelet Endothelial Cell Adhesion Molecule-1, Databases, Genetic, Transcriptome, Calbindin 1
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