The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice
Open accessPublished version of a preprint
Abstract
Abstract Although the antidepressant effect of magnolol has been revealed in previous reports, the mechanism remains unclear. In this study, the antidepressant effect of magnolol on corticosterone-induced (CORT-induced) depressed mice was investigated in vivo. After 21 days of CORT induction, the mice showed marked depressive-like behaviors, with a decrease in sucrose preference score and an increase in immobility time in tail suspension test (TST) and forced swimming test (FST). Pretreatment with either magnolol (50 mg/kg, i.p.) or the kappa opioid receptor (KOR) antagonist nor-BNI (10 mg/kg, i.p.) prevented CORT-induced depression-like behavior and reduced CORT-induced dynorphin (DYN A) elevation in the hippocampal DG. However, no depression-like behavior was observed in mice with KOR downregulation in the DG. We further found that upregulation of DYN A in the DG caused depression, which was blocked by intraperitoneal injection of nor-BNI and modulated by magnolol. The present study demonstrated that magnolol could ameliorate CORT-induced depression-like behaviors, by modulating the DYN A/KOR system in the DG of the hippocampus.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Shorey, S., Ng, E. D., & Wong, C. H. J. (2022) · British Journal of Clinical Psychology · doi:10.1111/bjc.12333 · Cited by 1,511 · see citing works
Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works
Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408 · see citing works
Zhang, K., Wang, F., Zhai, M., He, M., Hu, Y., Feng, L., Li, Y., Yang, J., & Wu, C. (2023) · Theranostics · doi:10.7150/thno.81067 · Cited by 217 · see citing works
Kong, H., Zeng, X., Fan, Y., Yuan, S., Ge, S., Xie, W., Wang, H., & Hu, G. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12222 · Cited by 72 · see citing works
Flagged first, then by citations
- Authors
- Xu, C., Ye, J., Sun, Y., Sun, X., & Liu, J.-G.
- Affiliations
- Zhejiang Chinese Medical University (CN)
- Corresponding author
- Xu, Chi
- Liu, Jing-gen
- Venue
- Journal of Molecular Neuroscience
- Published
- 2024-01-06
- Volume
- 74
- Issue
- 1
- Pages
- 3-3
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W4390636677
- Cited by
- 8
- References
- 5
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- dx.doi.org
- Licence
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Zhejiang Province (LY22H270004)
- Zhejiang Chinese Medical University (2022FSYYZZ11)
- National Natural Science Foundation of China (82030112)
- Topics
- Health Sciences › Medicine › Rehabilitation › Magnolia and Illicium research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- magnolol, antidepressant effects, depression-like behavior, corticosterone, chronic stress, kappa opioid receptor, nor-binaltorphimine, dynorphin A, ventral dentate gyrus, hippocampus, sucrose preference, immobility time, tail suspension test, forced swim test
- MeSH terms
- Animals, Antidepressive Agents, Biphenyl Compounds, Corticosterone, Depression, Lignans, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
