Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens
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Drugs of abuse regulate the transcription factor cAMP response element-binding protein (CREB) in striatal regions, including the nucleus accumbens (NAc). To explore how regulation of CREB in the NAc affects behavior, we used herpes simplex virus (HSV) vectors to elevate CREB expression in this region or to overexpress a dominant-negative mutant CREB (mCREB) that blocks CREB function. Rats treated with HSV-mCREB in place conditioning studies spent more time in environments associated with cocaine, indicating increased cocaine reward. Conversely, rats treated with HSV-CREB spent less time in cocaine-associated environments, indicating increased cocaine aversion. Studies in which drug-environment pairings were varied to coincide with either the early or late effects of cocaine suggest that CREB-associated place aversions reflect increased cocaine withdrawal. Because cocaine withdrawal can be accompanied by symptoms of depression, we examined how altered CREB function in the NAc affects behavior in the forced swim test (FST). Elevated CREB expression increased immobility in the FST, an effect that is opposite to that caused by standard antidepressants and is consistent with a link between CREB and dysphoria. Conversely, overexpression of mCREB decreased immobility, an effect similar to that caused by antidepressants. Moreover, the kappa opioid receptor antagonist nor-Binaltorphimine decreased immobility in HSV-CREB- and HSV-mCREB-treated rats, suggesting that CREB-mediated induction of dynorphin (an endogenous kappa receptor ligand) contributes to immobility behavior in the FST. Exposure to the FST itself dramatically increased CREB function in the NAc. These findings raise the possibility that CREB-mediated transcription within the NAc regulates dysphoric states.
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The NAC shell is activated during stress in rats and mice, and this activation in mice is blocked by a CRF-R1 antagonist.
“The NAC shell is activated during stress in rats and mice, and this same activation in mice is blocked by CRF-R1 antagonist (Pliakas et al 2001; Kreibich et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Pliakas et al 2001
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Cites
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464 · see citing works
CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,135 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Molecular basis of long-term plasticity underlying addiction
Nestler, E. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053570 · Cited by 1,857 · see citing works
Self-citationAn opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704 · see citing works
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works
Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor
Chavkin, C., James, I. F., & D, A. G. M. (1982) · Science · doi:10.1126/science.6120570 · Cited by 1,171 · see citing works
Psychotomimesis Mediated by κ Opiate Receptors
Pfeiffer, A., Brantl, V., Herz, A., & Emrich, H. M. (1986) · Science · doi:10.1126/science.3016896 · Cited by 857 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Self-citationDrug dependence: stress and dysregulation of brain reward pathways
Kreek, M. J., & Koob, G. F. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00064-7 · Cited by 696 · see citing works
Drug-activation of brain reward pathways
Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684 · see citing works
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz, M. B., Chen, J., Carlezon, W. A., Whisler, K., Gilden, L., Beckmann, A. M., Steffen, C., Zhang, Y.-J., Marotti, L., Self, D. W., et al. (1999) · Nature · doi:10.1038/45790 · Cited by 641 · see citing works
Self-citationSpanagel, R., Herz, A., & Shippenberg, T. S. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04963.x · Cited by 539 · see citing works
Heim, C., & Nemeroff, C. B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00224-3 · Cited by 502 · see citing works
An Opponent-Process Theory of Motivation
Solomon, R. L., & Corbit, J. D. (2008) · Cited by 461 · see citing works
Cole, R. L., Konradi, C. L., DOUGLASS, J. O., & Hyman, S. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90225-2 · Cited by 365 · see citing works
Self-citationDesipramine Facilitation of Initial Cocaine Abstinence
Gawin, F. H. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810020019004 · Cited by 361 · see citing works
Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
Carlezon, & Wise, R. A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-03112.1996 · Cited by 327 · see citing works
Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325 · see citing works
Self-citationSensitization to Morphine Induced by Viral-Mediated Gene Transfer
Carlezon, W. A., Boundy, V. A., Haile, C. N., Lane, S. B., Kalb, R. G., Neve, R. L., & Nestler, E. J. (1997) · Science · doi:10.1126/science.277.5327.812 · Cited by 279 · see citing works
Self-citationSpangler, R., Unterwald, E. M., & Kreek, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90133-a · Cited by 210 · see citing works
Cocaine self-administration differentially alters mRNA expression of striatal peptides
Hurd, Y. L., Brown, E. E., Finlay, J. M., Fibiger, H. C., & Gerfen, C. R. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90058-j · Cited by 199 · see citing works
Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediated
Bals-Kubik, R., Herz, A., & Shippenberg, T. S. (1989) · Psychopharmacology · doi:10.1007/bf00444692 · Cited by 199 · see citing works
Takahashi, M., Terwilliger, R. Z., Lane, C. L., Mézeš, P., Conti, M., & Duman, R. S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-02-00610.1999 · Cited by 177 · see citing works
Habit-forming actions of nomifensine in nucleus accumbens
Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170 · see citing works
Self-citationCocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum
Daunais, J. B., Roberts, D. C. S., & McGinty, J. F. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00020 · Cited by 170 · see citing works
Rajadhyaksha, A. M., Barczak, A. K., Macias‐Konstantopoulos, W., Leveque, J., Lewis, S. E., & Konradi, C. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-15-06348.1999 · Cited by 165 · see citing works
Self-citationTurgeon, S. M., Pollack, A. E., & Fink, J. S. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01316-9 · Cited by 129 · see citing works
Neve, R. L., Howe, J. R., Hong, S. E., & Kalb, R. G. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00645-8 · Cited by 124 · see citing works
Self-citationCarlezon, W. A., Haile, C. N., Coppersmith, R., Hayashi, Y., Malinow, R., Neve, R. L., & Nestler, E. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-05-j0002.2000 · Cited by 98 · see citing works
Self-citationDesmethylimipramine attenuates cocaine withdrawal in rats
Markou, A., Hauger, R. L., & Koob, G. F. (1992) · Psychopharmacology · doi:10.1007/bf02245878 · Cited by 94 · see citing works
Modulation of morphine-induced sensitization by endogenous κ opioid systems in the rat
Spanagel, R., & Shippenberg, T. S. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90329-j · Cited by 90 · see citing works
Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research
Carlezon, Jr., Nestler, E. J., & Neve, R. L. (2000) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v14.i1.30 · Cited by 90 · see citing works
Self-citation“The free market” and the Asian crisis
Jones, G. (2000) · Critical Review · doi:10.1080/08913810008443546 · Cited by 85 · see citing works
Long term κ-opioid receptor blockade following nor-binaltorphimine
Jones, D. N. C., & Holtzman, S. G. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90055-9 · Cited by 85 · see citing works
Schwaninger, M., Schöfl, C., Blume, R., Rössig, L., & Knepel, W. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08750-4 · Cited by 79 · see citing works
Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists
Shippenberg, T. S., Bals-Kubik, R., Huber, A., & Herz, A. (1991) · Psychopharmacology · doi:10.1007/bf02244205 · Cited by 74 · see citing works
Flagged first, then by citations
1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Carr GD, Fibiger HC, Phillips AG (1989) Conditioned place preference as a measure of drug reward. In: The neuropharmacological basis of reward (Liebman JM, Cooper SJ, eds), pp 264 -319. Oxford: Clarendon.
Cited by
Sorted by citations
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Self-citationThe mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Self-citationStress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Charney, D. S. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.195 · Cited by 1,605 · see citing works
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationTzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108 · see citing works
Self-citationMolecular mechanisms of opioid receptor-dependent signaling and behavior
Al-Hasani, R., & Bruchas, M. R. (2011) · Anesthesiology · doi:10.1097/aln.0b013e318238bba6 · Cited by 1,067 · see citing works
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808 · see citing works
Regulation of gene expression and cocaine reward by CREB and ΔFosB
McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works
Self-citationThe Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System
Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601 · see citing works
Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli
Renthal, W., Maze, I., Krishnan, V., Covington, H. E., Xiao, G., Kumar, A., Russo, S. J., Graham, A., Tsankova, N., Kippin, T. E., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.032 · Cited by 599 · see citing works
Self-citationBiological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561 · see citing works
Self-citationThe dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
Bruchas, M. R., Land, B. B., & Chavkin, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.08.062 · Cited by 544 · see citing works
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
Barrot, M., Olivier, J. D. A., Perrotti, L. I., DiLeone, R. J., Berton, O., Eisch, A. J., Impey, S., Storm, D. R., Neve, R. L., Yin, J. C., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172091899 · Cited by 508 · see citing works
Self-citationChemogenetic Tools to Interrogate Brain Functions
Sternson, S. M., & Roth, B. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014048 · Cited by 506 · see citing works
Addiction as a stress surfeit disorder
Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483 · see citing works
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Mague, S. D., Pliakas, A. M., Todtenkopf, M. S., Tomasiewicz, H. C., Zhang, Y., Stevens, W. C., Jones, R. M., Portoghese, P. S., & Carlezon, W. A. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046433 · Cited by 485 · see citing works
Self-citationThe Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Kozlowska, K., Walker, P., McLean, L., & Carrive, P. (2015) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000065 · Cited by 468 · see citing works
Dynorphin, stress, and depression
Knoll, A. T., & Carlezon, W. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.074 · Cited by 465 · see citing works
Self-citationWang, H., Xu, J., Lazarovici, P., Quirion, R., & Zheng, W. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00255 · Cited by 433 · see citing works
Historical review: molecular and cellular mechanisms of opiate and cocaine addiction
Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425 · see citing works
Self-citationMcLaughlin, J. P., Marton-Popovici, M., & Chavkin, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05674.2003 · Cited by 432 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Self-citationSharma, S., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.48 · Cited by 424 · see citing works
Neurobiology of addiction. An integrative review.
Goodman, A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 410 · see citing works
Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models
Schmidt, H. D., & Duman, R. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.114 · Cited by 403 · see citing works
The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse
Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works
Addiction is a Reward Deficit and Stress Surfeit Disorder
Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397 · see citing works
Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence
Walker, B. M., & Koob, G. F. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301438 · Cited by 392 · see citing works
Carlezon, W. A., Béguin, C., DiNieri, J. A., Baumann, M. H., Richards, M. R., Todtenkopf, M. S., Rothman, R. B., Ma, Z., Lee, D. Y.-W., & Cohen, B. M. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092304 · Cited by 390 · see citing works
Self-citationDynorphin and the pathophysiology of drug addiction
Shippenberg, T. S., Zapata, A., & Chefer, V. I. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.011 · Cited by 387 · see citing works
The Role of CREB in Depression and Antidepressant Treatment
Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works
The comorbidity of insomnia, chronic pain, and depression: Dopamine as a putative mechanism
Finan, P. H., & Smith, M. T. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.03.003 · Cited by 367 · see citing works
Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action
Lucas, G., Rymar, V. V., Du, J., Mnie‐Filali, O., Bisgaard, C. F., Manta, S., Lambás‐Señas, L., Wiborg, O., Haddjeri, N., Piñeyro, G., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.041 · Cited by 360 · see citing works
Wallace, D. L., Han, M.-H., Graham, D. L., Green, T. A., Vialou, V., Iñiguez, S. D., Cao, J.-L., Kirk, A., Chakravarty, S., Kumar, A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2257 · Cited by 342 · see citing works
Self-citationCommon Molecular and Cellular Substrates of Addiction and Memory
Nestler, E. J. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4084 · Cited by 354 · see citing works
Self-citationNeuroplasticity Mediated by Altered Gene Expression
McClung, C. A., & Nestler, E. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301544 · Cited by 347 · see citing works
Self-citationMolecular Neurobiology of Drug Addiction
Chao, J. R., & Nestler, E. J. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.103730 · Cited by 346 · see citing works
Self-citationRubino, T., Vigano', D., Realini, N., Guidali, C., Braida, D., Capurro, V., Castiglioni, C., Cherubino, F., Romualdi, P., Candeletti, S., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301664 · Cited by 345 · see citing works
The Role of BDNF in Depression on the Basis of Its Location in the Neural Circuitry
Yu, H., & Chen, Z.-Y. (2011) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.184 · Cited by 343 · see citing works
Conti, A. C., Cryan, J. F., Dalvi, A., Lucki, I., & Blendy, J. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03262.2002 · Cited by 328 · see citing works
Haglund, M., Nestadt, P. S., Cooper, N. S., Southwick, S. M., & Charney, D. S. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000430 · Cited by 315 · see citing works
Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works
Self-citationBeardsley, P. M., Howard, J. L., Shelton, K. L., & Carroll, F. I. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0167-4 · Cited by 312 · see citing works
Shirayama, Y., Ishida, H., Iwata, M., Hazama, G., Kawahara, R., & Duman, R. S. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02589.x · Cited by 305 · see citing works
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“The NACs is activated during stress in rats and mice, and this same activation in mice is blocked by CRF-R1 antagonist (Pliakas et al. 2001; Kreibich et al. 2009).”
Behavioral animal models of depression
Yan, H., Cao, X., Das, M. K., Zhu, X., & Gao, T. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0323-7 · Cited by 296 · see citing works
A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Self-citationStress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria
Bruchas, M. R., Land, B. B., Aita, M., Xu, M., Barot, S. K., Li, S., & Chavkin, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3769-07.2007 · Cited by 282 · see citing works
Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats
Todtenkopf, M. S., Marcus, J. F., Portoghese, P. S., & Carlezon, W. A. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1680-y · Cited by 273 · see citing works
Self-citationBolaños, C. A., Barrot, M., Berton, O., Wallace-Black, D., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00570-5 · Cited by 267 · see citing works
Self-citationWilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
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Andersen, S. L., Arvanitogiannis, A., Pliakas, A. M., LeBlanc, C., & Carlezon, W. A. (2002) · Nature Neuroscience · doi:10.1038/nn777 · Cited by 259 · see citing works
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Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 254 · see citing works
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McLaughlin, J. P., Li, S., Valdez, J., Chavkin, T. A., & Chavkin, C. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300872 · Cited by 253 · see citing works
Selecting an Appropriate Animal Model of Depression
Hao, Y., Ge, H., Sun, M., & Gao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194827 · Cited by 247 · see citing works
Enduring behavioral effects of early exposure to methylphenidate in rats
Carlezon, W. A., Mague, S. D., & Andersen, S. L. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.020 · Cited by 248 · see citing works
Self-citationVoorhees, J. L., Tarr, A. J., Wohleb, E. S., Godbout, J. P., Mo, X., Sheridan, J. F., Eubank, T. D., & Marsh, C. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058488 · Cited by 236 · see citing works
The antidepressant effect of running is associated with increased hippocampal cell proliferation
Bjørnebekk, A., Mathé, A. A., & Brené, S. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005122 · Cited by 231 · see citing works
Innovative approaches for the development of antidepressant drugs: Current and future strategies
Schechter, L. E., Ring, R. H., Beyer, C. E., Hughes, Z. A., Khawaja, X. Z., Malberg, J. E., & Rosenzweig-Lipson, S. J. (2005) · NeuroRx · doi:10.1602/neurorx.2.4.590 · Cited by 229 · see citing works
Knoll, A. T., Meloni, E. G., Thomas, J. B., Carroll, F. I., & Carlezon, W. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127415 · Cited by 227 · see citing works
Self-citationMcLaughlin, J. P., Land, B. B., Li, S., Pintar, J. E., & Chavkin, C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300860 · Cited by 226 · see citing works
Shirayama, Y., & Chaki, S. (2006) · Current Neuropharmacology · doi:10.2174/157015906778520773 · Cited by 225 · see citing works
Epigenetics of stress adaptations in the brain
Stankiewicz, A. M., Swiergiel, A. H., & Lisowski, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.07.003 · Cited by 220 · see citing works
kappa-Opioid receptor signaling and brain reward function
Bruijnzeel, A. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.008 · Cited by 214 · see citing works
Shaw-Lutchman, T. Z., Barrot, M., Wallace, T. L., Gilden, L., Zachariou, V., Impey, S., Duman, R. S., Storm, D. R., & Nestler, E. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03663.2002 · Cited by 205 · see citing works
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Cryan, J. F., Hoyer, D., & Markou, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01730-4 · Cited by 199 · see citing works
Bergström, A., Jayatissa, M. N., Mørk, A., & Wiborg, O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.12.025 · Cited by 196 · see citing works
Antidepressant action: to the nucleus and beyond
Malberg, J. E., & Blendy, J. A. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.005 · Cited by 193 · see citing works
Green, T. A., Alibhai, I. N., Roybal, C. N., Winstanley, C. A., Theobald, D. E. H., Birnbaum, S. G., Graham, A., Unterberg, S., Graham, D. L., Vialou, V., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.022 · Cited by 177 · see citing works
Self-citationPandey, S. C., Roy, A., & Zhang, H. (2003) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000056616.81971.49 · Cited by 168 · see citing works
Dudman, J. T., Eaton, M. E., Rajadhyaksha, A. M., Macias‐Konstantopoulos, W., Taher, M., Barczak, A. K., Kameyama, K., Huganir, R. L., & Konradi, C. L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02067.x · Cited by 170 · see citing works
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Gourley, S. L., & Taylor, J. R. (2009) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0932s49 · Cited by 168 · see citing works
Wright, J. S., & Panksepp, J. (2012) · Neuropsychoanalysis · doi:10.1080/15294145.2012.10773683 · Cited by 153 · see citing works
Bambico, F. R., Nguyen, N.-T., Katz, N., & Gobbi, G. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.020 · Cited by 161 · see citing works
Carlezon, W. A., Mague, S. D., Parow, A. M., Stoll, A. L., Cohen, B. M., & Renshaw, P. F. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.038 · Cited by 162 · see citing works
Self-citationRegulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens
Barrot, M., Wallace, D. L., Bolaños, C. A., Graham, D. L., Perrotti, L. I., Neve, R. L., Chambliss, H., Yin, J. C. P., & Nestler, E. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500587102 · Cited by 162 · see citing works
Self-citationDevelopment of κ Opioid Receptor Antagonists
Carroll, F. I., & Carlezon, W. A. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301783x · Cited by 162 · see citing works
Self-citationKappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials
Carlezon, W. A., & Krystal, A. D. (2016) · Depression and Anxiety · doi:10.1002/da.22500 · Cited by 160 · see citing works
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Tejeda, H. A., Shippenberg, T. S., & Henriksson, R. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0844-x · Cited by 155 · see citing works
Kappa-opioid ligands in the study and treatment of mood disorders
Carlezon, W. A., Béguin, C., Knoll, A. T., & Cohen, B. M. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.05.008 · Cited by 156 · see citing works
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Edwards, S., & Koob, G. F. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283644d15 · Cited by 151 · see citing works
Rorick‐Kehn, L. M., Witkin, J. M., Statnick, M. A., Eberle, E. L., McKinzie, J. H., Kahl, S. D., Forster, B. M., Wong, C. J., Li, X., Crile, R. S., et al. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.09.021 · Cited by 152 · see citing works
Morishima, Y., Miyakawa, T., Furuyashiki, T., Tanaka, Y., Mizuma, H., & Nakanishi, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500914102 · Cited by 148 · see citing works
Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice
LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.024 · Cited by 136 · see citing works
Self-citationPar-4 Links Dopamine Signaling and Depression
Park, S. K., Nguyen, M. D., Fischer, A., Luke, M. P.-S., Affar, E. B., Dieffenbach, P. B., Tseng, H.-C., Shi, Y., & Tsai, L. (2005) · Cell · doi:10.1016/j.cell.2005.05.031 · Cited by 144 · see citing works
Stress responses and the mesolimbic dopamine system: Social contexts and sex differences
Trainor, B. C. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.013 · Cited by 138 · see citing works
Use of Herpes Virus Amplicon Vectors to Study Brain Disorders
Neve, R. L., Neve, K. A., Nestler, E. J., & Carlezon, W. A. (2005) · BioTechniques · doi:10.2144/05393ps01 · Cited by 144 · see citing works
Self-citationChartoff, E. H., Sawyer, A. M., Rachlin, A. B., Potter, D., Pliakas, A. M., & Carlezon, W. A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.014 · Cited by 143 · see citing works
Self-citationGoffer, Y., Xu, D., Eberle, S. E., D’amour, J. A., Lee, M., Tukey, D. S., Froemke, R. C., Ziff, E. B., & Wang, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2454-13.2013 · Cited by 142 · see citing works
Knoll, A. T., Muschamp, J. W., Daws, S. E., Ferguson, D., Dietz, D., Meloni, E. G., Carroll, F. I., Nestler, E. J., Konradi, C. L., & Carlezon, W. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.017 · Cited by 141 · see citing works
Self-citationNair, A. R., & Vaidya, V. A. (2006) · Journal of Biosciences · doi:10.1007/bf02704114 · Cited by 139 · see citing works
Tejeda, H. A., Wu, J., Kornspun, A. R., Pignatelli, M., Kashtelyan, V., Krashes, M. J., Lowell, B. B., Carlezon, W. A., & Bonci, A. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.005 · Cited by 134 · see citing works
Self-citationZhou, J. R., Zhang, H., Cohen, R. S., & Pandey, S. C. (2005) · Neuroendocrinology · doi:10.1159/000088448 · Cited by 137 · see citing works
Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction
Chartoff, E. H., & Mavrikaki, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00466 · Cited by 134 · see citing works
cAMP Response Element-Binding Protein Is Required for Stress But Not Cocaine-Induced Reinstatement
Kreibich, A. S., & Blendy, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1706-04.2004 · Cited by 134 · see citing works
- Authors
- Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A.
- Affiliations
- Harvard University (US)
- The University of Texas Southwestern Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-09-15
- Volume
- 21
- Issue
- 18
- Pages
- 7397-7403
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4205577
- OpenAlex
- W1928329059
- Cited by
- 509
- References
- 42
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 12 · 2019: 13 · 2018: 12 · 2017: 20 · 2016: 21 · 2015: 22 · 2014: 23 · 2013: 28 · 2012: 33
- FWCI
- 7.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health
- National Institute on Drug Abuse (R01DA007134)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CREB, nucleus accumbens, cocaine reward, cocaine withdrawal, depression-like behavior, kappa opioid receptor, nor-binaltorphimine, dynorphin, dominant-negative CREB, place conditioning
- MeSH terms
- Animals, Cocaine, Conditioning, Psychological, Dynorphins, Genes, Dominant, Genetic Vectors, Male, Microinjections, Motor Activity, Narcotic Antagonists, Nucleus Accumbens, Reaction Time, Swimming, Gene Expression, Rats, Sprague-Dawley, Cyclic AMP Response Element-Binding Protein, Receptors, Opioid, kappa, Gene Transfer Techniques, Simplexvirus, Hypokinesia, Rats
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