CoChat
Sign Up
Cited by 91Prostate Cancer Treatment and ResearchNF-κB Signaling PathwaysSignaling Pathways in Disease

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

SHARPIN overexpression induces tumorigenesis in human prostate cancer LNCaP, DU145 and PC-3 cells via NF-κB/ERK/Akt signaling pathway

Li, Jin, Lai, Yiming, Cao, Yi, Du, Tao, Zeng, Lexiang, Wang, Ganping, Chen, Xianju, Chen, Jieqing, Yu, Yongsheng, Zhang, Simin, Zhang, Yiming, Huang, Hai, Guo, Zhenghui·2015·Medical Oncology
DOI 10.1007/s12032-014-0444-3
Open this paper in CoChat — free account

Abstract

SHARPIN emerges higher expression in prostate cancerous tissues than in benign prostate hyperplasia by means of immunohistochemistry in our previous study. In this work, we performed the gain of function assay and find that overexpression of SHARPIN in LNCaP, DU145 and PC-3 cells promoted cell proliferation, invasiveness and reduced apoptosis. Furthermore, SHARPIN overexpression displayed elevated Bcl-2 and Survivin expression and reduced levels of Bax, cleaved caspase-3. Meanwhile, entropic expression of SHARPIN increased the levels of phosphorylated p65, IkBα, ERK and Akt, were selectively increased in these cells. Collectively, our study unraveled the ability of SHARPIN overexpression to induce tumorigenesis of prostate cancer cells through the NF-kB/ERK/Akt pathway and transformation of apoptosis-associated proteins.

Overview

Integrity signals

Registry

Crossref · 10.1007/s12032-014-0444-3

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 26

  1. Siegel R, DeSantis C, Virgo K, Stein K, Mariotto A, Smith T, Cooper D, Gansler T, Lerro C, Fedewa S, Lin C, Leach C, Cannady RS, Cho H, Scoppa S, Hachey M, Kirch R, Jemal A, Ward E. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62:220–41. · DOI
  2. Sheng M, Kim E. The Shank family of scaffold proteins. J Cell Sci. 2000;113:1851–6. · DOI · Paper page
  3. Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJL, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature. 2011;471:637–41. · DOI · Paper page
  4. Tokunaga F, Iwai K. LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses. Microbes Infect. 2012;14:563–72. · DOI
  5. Jung J, Kim JM, Park B, Cheon Y, Lee B, Choo SH, Koh SS, Lee S. Newly identified tumor-associated role of human Sharpin. Mol Cell Biochem. 2010;340:161–7. · DOI · Paper page
  6. Zhang Y, Huang H, Zhou H, Du T, Zeng L, Cao Y, Chen J, Lai Y, Li J, Wang G, Guo Z. Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer. Cancer 2014;120:3208–18. · DOI
  7. Ali AS, Ali S, El-Rayes BF, Philip PA, Sarkar FH. Exploitation of protein kinase C: a useful target for cancer therapy. Cancer Treat Rev. 2009;35:1–8. · DOI
  8. DiDonato JA, Mercurio F, Karin M. NF-κB and the link between inflammation and cancer. Immunol Rev. 2012;246(1):379–400. · DOI
  9. Jin R, Yi Y, Yull FE, Blackwell TS, Clark PE, Koyama T, Smith JA, Matusik RJ. NF-κb gene signature predicts prostate cancer progression. Cancer Res. 2014;74(10):2763–72. · DOI
  10. Nguyen DP, Li J, Yadav SS, Tewari AK. Recent insights into NF-κB signalling pathways and the link between inflammation and prostate cancer. Bju Int. 2014;114(2):168–76. · DOI
  11. Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005;24(5):7455–64. · DOI
  12. He L, Ingram A, Rybak AP, Tang D. Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells. J Clin Invest. 2010;120(6):2094–108. · DOI
  13. Toulany M, Minjgee M, Saki M, Holler M, Meier F, Eicheler W, Rodemann HP. ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3 K inhibition. Cancer Biol Ther. 2014;15(3):317–28. · DOI
  14. Suire S, Hawkins P, Stephens L. Activation of Phosphoinositide 3-Kinase γ by Ras. Curr Biol. 2002;12(13):1068–75. · DOI
  15. Zimmermann S. Phosphorylation and regulation of raf by akt (Protein kinase b). Science. 1999;286(5445):1741–4. · DOI
  16. Deschenes-Simard X, Kottakis F, Meloche S, Ferbeyre G. ERKs in Cancer: friends or Foes? Cancer Res. 2014;74(2):412–9. · DOI · Paper page
  17. Pommier Y, Sordet O, Antony S, Hayward RL, Kohn KW. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene. 2004;23(16):2934–49. · DOI
  18. Strasser A, Cory S, Adams JM. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J. 2011;30(18):3667–83. · DOI
  19. Fernald K, Kurokawa M. Evading apoptosis in cancer. Trends Cell Biol. 2013;23(12):620–33. · DOI
  20. Liu C, Yang J, Fu W, Qi S, Wang C, Quan C, Yang K. Coactivation of the PI3 K/Akt and ERK signaling pathways in PCB153-induced NF-κB activation and caspase inhibition. Toxicol Appl Pharm. 2014;277(3):270–8. · DOI
  21. Liu Y, He J, Chen X, Li J, Shen M, Yu W, Yang Y, Xiao Z. The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and akt pathways. Cell Physiol Biochem. 2014;34(3):637–45. · DOI
  22. Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N. Apoptosis and molecular targeting therapy in cancer. BioMed Res Int. 2014;2014:150845.
  23. Ye Q, Cai W, Zheng Y, Evers BM, She Q. ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. Oncogene. 2013;33(14):1828–39. · DOI
  24. Tyagi N, Bhardwaj A, Singh AP, McClellan S, Carter JE, Singh S. P-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-kappaB pathway. Oncotarget. 2014;5(18):8778–89. · DOI
  25. Andersen MH, Svane IM, Becker JC, Straten PT. The universal character of the tumor-associated antigen survivin. Clin Cancer Res. 2007;13(20):5991–4. · DOI
  26. Kanwar JR, Kamalapuram SK, Kanwar RK. Survivin signaling in clinical oncology: a multifaceted dragon. Med Res Rev. 2013;33(4):765–89. · DOI

Cited by

Sorted by citations

Metadata

Authors
Li, J., Lai, Y., Cao, Y., Du, T., Zeng, L., Wang, G., Chen, X., Chen, J., Yu, Y., Zhang, S., Zhang, Y., Huang, H., & Guo, Z.
Affiliations
Sun Yat-sen University (CN)
Corresponding author
  • Huang, Hai
  • Guo, Zhenghui
ORCID
Venue
Medical Oncology
Publisher
Springer Science and Business Media LLC
Published
2015-01-01
Volume
32
Issue
2
Pages
104-104
ISSN
  • 1357-0560 (ISSN-L)
  • 1559-131X
DOI
10.1007/s12032-014-0444-3
OpenAlex
W1989317948
Cited by
91
References
2
Citations by year
2025: 10 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 13 · 2018: 6 · 2017: 17 · 2016: 12 · 2015: 7
FWCI
9.63
Type
journal article
Language
en
Update notices
correction (2021-07-31)
Open access
closed
Licence
Locations
  • Medical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
SHARPIN, prostate cancer, carcinogenesis, NF-κB signaling, ERK signaling, Akt signaling, apoptosis, cell proliferation, cell invasion, Bcl-2, survivin, Bax, caspase-3, IkBα, p65 phosphorylation, LNCaP cells, DU145 cells, PC-3 cells
MeSH terms
Cell Survival, Flow Cytometry, Humans, Male, Prostatic Neoplasms, Transfection, Ubiquitins, Blotting, Western, Signal Transduction, Up-Regulation, NF-kappa B, MAP Kinase Signaling System, Cell Line, Tumor, Cell Proliferation, Proto-Oncogene Proteins c-akt, Real-Time Polymerase Chain Reaction, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review