The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Open accessAbstract
A long-standing relationship between nicotinic acetylcholine receptors (nAChRs) and cognition exists. Drugs that act at nAChRs can have cognitive-enhancing effects and diseases that disrupt cognition such as Alzheimer's disease and schizophrenia are associated with altered nAChR function. Specifically, hippocampus-dependent learning is particularly sensitive to the effects of nicotine. However, the effects of nicotine on hippocampus-dependent learning vary not only with the doses of nicotine used and whether nicotine is administered acutely, chronically, or withdrawn after chronic nicotine treatment but also vary across different hippocampus-dependent tasks such as the Morris water maze, the radial arm maze, and contextual fear conditioning. In addition, nicotine has variable effects across different types of hippocampal long-term potentiation (LTP). Because different types of hippocampus-dependent learning and LTP involve different neural and molecular substrates, comparing the effects of nicotine across these paradigms can yield insights into the mechanisms that may underlie the effects of nicotine on learning and memory and aid in understanding the variable effects of nicotine on cognitive processes. This review compares and contrasts the effects of nicotine on hippocampus-dependent learning and LTP and briefly discusses how the effects of nicotine on learning could contribute to nicotine addiction.
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“Although craving and cognitive impairments are reliable markers of nicotine withdrawal (Kenney and Gould, 2008; Levin et al, 2006; McClernon et al, 2004; Rezvani and Levin, 2001), anxiety has been shown to impact relapse rate as well (Dani and Harris, 2005; DiMatteo et al, 2000).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Kenney and Gould, 2008
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“This hyperexcitability may underlie many of the nicotine withdrawal symptoms (Kenney et al, 2008).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Kenney et al, 2008
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“This strain was chosen because it performs well in fear conditioning (Owen et al., 1997) and is sensitive to the effects of nicotine on learning (Kenney and Gould, 2008).”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Kenney and Gould, 2008
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Items 201–228 of 228
Impaired behavioural flexibility and memory in mice lacking GDNF family receptor α2
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Self-citationThe Effects of Nicotine on Learning and Memory
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Self-citationKetanserin attenuates nicotine-induced working memory improvement in rats
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A Pharmacogenetic Inducible Approach to the Study of NMDA/αCaMKII Signaling in Synaptic Plasticity
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Alzheimer's disease amyloid β-protein and synaptic function
Ondrejcak, T., Klyubin, I., Hu, N.-W., Barry, A. E., Cullen, W. K., & Rowan, M. J. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8091-0 · Cited by 146
Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Kutlu, M. G., & Gould, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.029 · Cited by 97
Self-citationNicotinic mechanisms influencing synaptic plasticity in the hippocampus
Placzek, A. N., Zhang, T. A., & Dani, J. A. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.39 · Cited by 77
Kenney, J. W., Adoff, M. D., Wilkinson, D. S., & Gould, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2283-7 · Cited by 67
Self-citationGould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56
“the effects of nicotine on learning (Kenney and Gould, 2008).”
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Metadata
- Authors
- Kenney, J. W., & Gould, T. J.
- Affiliations
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Molecular Neurobiology
- Published
- 2008-08
- Volume
- 38
- Issue
- 1
- Pages
- 101-121
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC2683366
- OpenAlex
- W2130009335
- Cited by
- 242
- References
- 228
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 10 · 2022: 5 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 24 · 2015: 15 · 2014: 34 · 2013: 21 · 2012: 23
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA015515, R03AA015515)
- National Institute on Drug Abuse (DA017949, R01DA017949, DA 07237, T32DA007237)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- nicotine, nicotinic acetylcholine receptors, hippocampus-dependent learning, synaptic plasticity, long-term potentiation, learning and memory, nicotine withdrawal, cognitive enhancement, nicotine dependence, Alzheimer's disease, schizophrenia, contextual fear conditioning, Morris water maze, radial maze
- MeSH terms
- Animals, Hippocampus, Humans, Learning, Memory, Neuronal Plasticity, Nicotine, Receptors, Nicotinic, Long-Term Potentiation, Substance-Related Disorders
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