The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice
Open accessAbstract
Rationale Spatial and novel object recognition learning is different from learning that uses aversive or appetitive stimuli to shape acquisition because no overt contingencies are needed. While this type of learning occurs on a daily basis, little is known about how nicotine administration affects it.Objectives To determine the effects of acute, chronic, and withdrawal from chronic nicotine on two related but distinct incidental learning tasks, novel and spatial object recognition.Methods In C57BL/6J mice, the effects of acute (0.045-0.18 mg/kg), chronic (6.3 mg/kg/day), and withdrawal from chronic nicotine on novel and spatial object recognition were examined.Results With a 48-h delay between training and testing, acute nicotine enhanced spatial (difference score, saline = 3.34 s, nicotine = 7.71 s, p = 0.029) but resulted in a deficit in novel object recognition (difference score, saline = 8.76 s, nicotine = 4.48 s, p = 0.033). Chronic nicotine resulted in a strong trend towards a deficit in spatial object recognition (difference score, saline = 4.01 s, nicotine = 1.81 s, p = 0.059) but had no effect on novel object recognition, and withdrawal from chronic nicotine disrupted spatial object recognition (difference score, saline = 3.00 s, nicotine = 0.17 s, p = 0.004) but had no effect on novel object recognition.Conclusions The effects of nicotine on spatial object recognition shift from enhancement to deficit as administration changes from acute to chronic and withdrawal. These effects were specific for spatial object recognition, which may be due to differing underlying neural substrates involved in these tasks. Understanding how nicotine alters learning has implications for understanding diseases associated with altered cholinergic function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There was no effect on novel object recognition during nicotine withdrawal.
“there was no effect on novel object recognition (Kenney et al, 2011)”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Kenney et al, 2011
There is a selective deficit in spatial object recognition during nicotine withdrawal.
“there is a selective deficit in spatial object recognition during nicotine withdrawal”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Kenney et al, 2011
Withdrawal from chronic nicotine disrupts contextual learning in mice.
“Withdrawal from chronic nicotine disrupts contextual learning in mice and this deficit is mediated by direct effects of nicotine in the hippocampus.”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Kenney et al., 2011
Withdrawal-related learning deficits are specific to the hippocampus, as demonstrated for trace conditioning and spatial object recognition.
“This hippocampal specificity for learning-related withdrawal deficits has been shown for other learning tasks such as trace conditioning and spatial object recognition (Kenney et al., 2011; Raybuck and Gould, 2009)”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Kenney et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704 · see citing works
Eichenbaum (2004) · doi:10.1016/j.neuron.2004.08.028 · Cited by 1,464 · see citing works
Bevins, R. A., & Besheer, J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.205 · Cited by 1,278 · see citing works
Levin, E. D., McClernon, F. J., & Rezvani, A. H. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0164-7 · Cited by 820 · see citing works
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676 · see citing works
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.005 · Cited by 669 · see citing works
Meta-analysis of the acute effects of nicotine and smoking on human performance
Heishman, S. J., Kleykamp, B. A., & Singleton, E. G. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1848-1 · Cited by 651 · see citing works
Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 568 · see citing works
Hippocampal-Neocortical Interactions in Memory Formation, Consolidation, and Reconsolidation
Wang, S., & Morris, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100523 · Cited by 536 · see citing works
An Opponent-Process Theory of Motivation
Solomon, R. L., & Corbit, J. D. (2008) · Cited by 461 · see citing works
A selective mnemonic role for the hippocampus in monkeys: memory for the location of objects
Parkinson, J., Murray, E. A., & Mishkin, M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04159.1988 · Cited by 442 · see citing works
Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers.
Jacobsen, L. K., Krystal, J. H., Mencl, W. E., Westerveld, M., Frost, S. J., & Pugh, K. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.022 · Cited by 393 · cited 2× · see citing works
“In both animals and humans, withdrawal from chronic nicotine is known to result in learning and memory deficits (Domier et al. 2007; Jacobsen et al. 2005; Kenney and Gould 2008a; Mendrek et al. 2006) and in the present study, withdrawal from chronic nicotine administration resulted in a deficit in…”
Hippocampal place cells, context, and episodic memory
Smith, D. M., & Mizumori, S. J. Y. (2006) · Hippocampus · doi:10.1002/hipo.20208 · Cited by 302 · see citing works
An opponent-process theory of motivation. II. Cigarette addiction
Solomon, R. L., & Corbit, J. D. (1973) · Journal of Abnormal Psychology · doi:10.1037/h0034534 · Cited by 290 · see citing works
Modulation of Hippocampus-Dependent Learning and Synaptic Plasticity by Nicotine
Kenney, J. W., & Gould, T. J. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8037-9 · Cited by 242 · see citing works
Self-citationCholinergic Neurotransmission Is Essential for Perirhinal Cortical Plasticity and Recognition Memory
Warburton, E. C., Koder, T., Cho, K., Massey, P. V., Duguid, G., Barker, G. R. I., Aggleton, J. P., Bashir, Z. I., & Brown, M. W. (2003) · Neuron · doi:10.1016/s0896-6273(03)00358-1 · Cited by 226 · see citing works
Characterization of spontaneous and precipitated nicotine withdrawal in the mouse
Damaj, M. I., Kao, W., & Martin, B. R. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054908 · Cited by 222 · see citing works
Picciotto, M. R. (2007) · Frontiers in bioscience · doi:10.2741/2695 · Cited by 212 · see citing works
Acute and chronic nicotine exposure differentially facilitate the induction of LTP
Fujii, S., Ji, Z., Morita, N., & Sumikawa, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01982-4 · Cited by 200 · see citing works
Sex Differences in the Behavioral Response to Spatial and Object Novelty in Adult C57BL/6 Mice.
Frick, K. M., & Gresack, J. E. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1283 · Cited by 190 · see citing works
How the brain remembers and forgets where things are: The neurocognition of object–location memory
Postma, A., Kessels, R. P. C., & van Asselen, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.001 · Cited by 178 · see citing works
Warburton, E. C., & Brown, M. W. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.022 · Cited by 166 · see citing works
Working memory in cigarette smokers: Comparison to non-smokers and effects of abstinence
Mendrek, A., Monterosso, J. R., Simon, S. L., Jarvik, M. E., Brody, A. L., Olmstead, R. E., Domier, C. P., Cohen, M. S., Monique Ernst, D., & London, E. D. (2005) · Addictive Behaviors · doi:10.1016/j.addbeh.2005.06.009 · Cited by 161 · see citing works
Nicotine enhancement of contextual fear conditioning
Gould, T. J., & Wehner, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00157-0 · Cited by 151 · see citing works
Self-citationBachevalier, J., & Nemanic, S. (2007) · Hippocampus · doi:10.1002/hipo.20369 · Cited by 147 · see citing works
Withdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice
Davis, J. A., James, J. R., Siegel, S. J., & Gould, T. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2853-05.2005 · Cited by 146 · see citing works
Self-citationWinters, B. D., & Bussey, T. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04055.x · Cited by 141 · see citing works
Smoking and cognitive decline among middle-aged men and women: the Doetinchem Cohort Study.
Nooyens, A. C. J., van Gelder, B. V., & Verschuren, W. M. M. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.130294 · Cited by 135 · see citing works
Chronic nicotine and withdrawal effects on radial-arm maze performance in rats
Levin, E. D., Lee, C. K., Rose, J. E., Reyes, A., Ellison, G. D., Jarvik, M. E., & Gritz, E. R. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90509-5 · Cited by 130 · see citing works
Smoking History and Cognitive Function in Middle Age From the Whitehall II Study
Sabia, S. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.11.1165 · Cited by 128 · see citing works
Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training
Gould, T. J., & Stephen Higgins, J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00057-1 · Cited by 123 · see citing works
Self-citationLevin, E. D., Christopher, N. C., Briggs, S. J., & Rose, J. E. (1993) · Cognitive Brain Research · doi:10.1016/0926-6410(93)90021-v · Cited by 111 · see citing works
Long-term effects of chronic nicotine exposure on brain nicotinic receptors
Besson, M., Granon, S., Mameli-Engvall, M., Cloëz-Tayarani, I., Maubourguet, N., Cormier, A., Cazala, P., David, V., Changeux, J., & Fauré, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702698104 · Cited by 109 · see citing works
Nicotine improves memory in an object recognition task in rats
Puma, C., Deschaux, O., Molimard, R., & Bizot, J. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00002-4 · Cited by 107 · see citing works
Davis, J. A., Kenney, J. W., & Gould, T. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3242-07.2007 · Cited by 107 · see citing works
Self-citationde Bruin, N. M. W. J., & POUZET, B. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.08.007 · Cited by 98 · see citing works
Nicotine abstinence in the mouse
Isola, R., Vogelsberg, V., Wemlinger, T. A., Neff, N. H., & Hadjiconstantinou, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02131-9 · Cited by 96 · see citing works
Historical context of state dependent learning and discriminative drug effects
Overton, D. A. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199109000-00002 · Cited by 88 · see citing works
Deficits in a sustained attention task following nicotine withdrawal in rats
Shoaib, M., & Bizarro, L. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2004-6 · Cited by 87 · see citing works
Abdulla, F. A., Gray, J. A., Sinden, J. D., Bradbury, E. J., Calaminici, M., Lippiello, P. M., & Wonnacott, S. (1996) · Psychopharmacology · doi:10.1007/bf02247437 · Cited by 85 · see citing works
Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
Gould, T. J., Feiro, O., & Moore, D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.009 · Cited by 78 · see citing works
Self-citationPortugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66 · see citing works
Self-citationScerri, C., Stewart, C. A., Breen, K. C., & Balfour, D. J. K. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0086-4 · Cited by 61 · see citing works
Neuronal Nicotinic Acetylcholine Receptors: Involvement in Alzheimer’s Disease and Schizophrenia
Woodruff‐Pak, D. S., & Gould, T. J. (2002) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582302001001002 · Cited by 60 · see citing works
Self-citationHippocampal nAChRs mediate nicotine withdrawal-related learning deficits
Davis, J. A., & Gould, T. J. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.02.003 · Cited by 60 · see citing works
Self-citationCholinergic drugs affect novel object recognition in rats: Relation with hippocampal EEG?
Sambeth, A., Riedel, W. J., Smits, L. T., & Blokland, A. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.018 · Cited by 58 · see citing works
Raybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53 · see citing works
Self-citationSharifzadeh, M. S., Tavasoli, M., Naghdi, N., Ghanbari, A., Amini, M., & Roghani, A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03454.x · Cited by 51 · see citing works
Effects of cigarette smoking and abstinence on stroop task performance
Domier, C. P., Monterosso, J. R., Brody, A. L., Simon, S. L., Mendrek, A., Olmstead, R. E., Jarvik, M. E., Cohen, M. S., & London, E. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0869-x · Cited by 47 · see citing works
Nicotine enhances context learning but not context-shock associative learning.
Kenney, J. W., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012807 · Cited by 45 · see citing works
Self-citationOkada, K., & Okaichi, H. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.007 · Cited by 37 · see citing works
Gaskin, S., Gamliel, A., Tardif, M., Cole, E., & Mumby, D. G. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.016 · Cited by 37 · see citing works
Effects of nicotine on spatial learning in C57BL mice
Bernal, M. C., Vicens, P., Carrasco, M. C., & Redolat, R. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199905000-00010 · Cited by 34 · see citing works
Impact of nicotine withdrawal on novelty reward and related behaviors.
Besheer, J., & Bevins, R. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.327 · Cited by 33 · see citing works
Yamazaki, Y., Fujii, S., Jia, Y., & Sumikawa, K. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05160.x · Cited by 29 · see citing works
Bevins, R. A., Penrod, R. D., & Reichel, C. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.026 · Cited by 21 · see citing works
Bura, S. A., Castañé, A., Ledent, C. A., Valverde, O., & Maldonado, R. J. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707152 · Cited by 21 · see citing works
White, N. M., Holahan, M. R., & Goffaux, P. (2003) · Hippocampus · doi:10.1002/hipo.10080 · Cited by 18 · see citing works
Horne, M. R., Iordanova, M. D., Albasser, M. M., Aggleton, J. P., Honey, R. C., & Pearce, J. M. (2010) · Behavioral Neuroscience · doi:10.1037/a0019287 · Cited by 18 · see citing works
Environmental Familiarization in Rats: Differential Effects of Acute and Chronic Nicotine
Bevins, R. A., Koznarova, J., & Armiger, T. J. (2001) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3955 · Cited by 15 · see citing works
Chronic nicotine exposure affects the normal operation of hippocampal circuits
Nakauchi, S., Yamazaki, Y., & Sumikawa, K. (2007) · Neuroreport · doi:10.1097/wnr.0b013e328011b883 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kutlu, M. G., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042192.116 · Cited by 324 · see citing works
Self-citationCognitive function during nicotine withdrawal: Implications for nicotine dependence treatment
Ashare, R. L., Falcone, M., & Lerman, C. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.034 · Cited by 170 · see citing works
Nicotine Gateway Effects on Adolescent Substance Use
Ren, M., & Lotfipour, S. (2019) · Western Journal of Emergency Medicine · doi:10.5811/westjem.2019.7.41661 · Cited by 166 · see citing works
Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
Vicidomini, C., Ponzoni, L., Lim, D., Schmeißer, M. J., Reim, D., Morello, N., Orellana, D. I., Tozzi, A., Durante, V., Scalmani, P., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.30 · Cited by 141 · see citing works
Cholinergic modulation of spatial learning, memory and navigation
Solari, N., & Hangya, B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14089 · Cited by 139 · see citing works
Different physiological and behavioural effects of e-cigarette vapour and cigarette smoke in mice
Ponzoni, L., Moretti, M., Sala, M., Fasoli, F., Mucchietto, V, Lucini, V, Cannazza, G., Gallesi, G., Castellana, C., Clementi, F., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.010 · Cited by 91 · see citing works
Myosin IXa Binds AMPAR and Regulates Synaptic Structure, LTP, and Cognitive Function
Folci, A., Murru, L., Vezzoli, E., Ponzoni, L., Gerosa, L., Moretto, E., Longo, F., Zapata, J., Braida, D., Pistillo, F., et al. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00001 · Cited by 82 · see citing works
Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
Portugal, G. S., Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.003 · Cited by 79 · see citing works
Self-citationCellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 68 · see citing works
Self-citationNicotine’s effect on cognition, a friend or foe?
Wang, Q., Du, W., Wang, H., Geng, P., Sun, Y., Zhang, J., Wang, W., & Jin, X. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110723 · Cited by 66 · see citing works
Kenney, J. W., Raybuck, J. D., & Gould, T. J. (2012) · Hippocampus · doi:10.1002/hipo.22003 · Cited by 65 · see citing works
Self-citationMesa‐Gresa, P., Pérez‐Martinez, A., & Redolat, R. (2013) · Aggressive Behavior · doi:10.1002/ab.21481 · Cited by 66 · see citing works
Rodent models for nicotine withdrawal
Chellian, R., Behnood‐Rod, A., Bruijnzeel, D. M., Wilson, R., Pandy, V., & Bruijnzeel, A. W. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211005629 · Cited by 68 · see citing works
Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory
Kutlu, M. G., & Gould, T. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.12.008 · Cited by 62 · see citing works
Self-citationBudzyńska, B., Boguszewska‐Czubara, A., Kruk-Słomka, M., Skalicka‐Woźniak, K., Michalak, A., Musik, I., Biała, G., & Głowniak, K. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.019 · Cited by 64 · see citing works
Gould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56 · see citing works
“…of nicotine that produces plasma nicotine levels in the range seen in smokers showed deficits specifically in hippocampus-dependent learning such as contextual fear conditioning, trace conditioning, and spatial object recognition (Davis et al., 2005; Kenney et al., 2011; Raybuck and Gould, 2009).”
InfluentialSelf-citationNicotinic receptor activation in perirhinal cortex and hippocampus enhances object memory in rats
Melichercik, A. M., Elliott, K. S., Bianchi, C., Ernst, S. M., & Winters, B. D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.008 · Cited by 54 · see citing works
Terry, A. V., & Callahan, P. M. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty166 · Cited by 47 · see citing works
Nicotinic Receptors, Memory, and Hippocampus
Kutlu, M. G., & Gould, T. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13665-3_6 · Cited by 41 · see citing works
Self-citationH63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment
Ali-Rahmani, F. G., Grigson, P. S., Lee, S. Y., Neely, E. B., Connor, J. R., & Schengrund, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.014 · Cited by 32 · see citing works
Saravia, R., Flores, Á., Plaza‐Zabala, A., Busquets-García, A., Pastor, A., de la Torre, R., Marzo, V. D., Marsicano, G., Ozaita, A., Maldonado, R. J., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.07.007 · Cited by 31 · see citing works
Mephedrone and Nicotine: Oxidative Stress and Behavioral Interactions in Animal Models
Budzyńska, B., Boguszewska‐Czubara, A., Kruk-Słomka, M., Kurzepa, J., & Biała, G. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1566-5 · Cited by 32 · see citing works
Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal
Turner, J. R., Wilkinson, D. S., Poole, R. L., Gould, T. J., Carlson, G. C., & Blendy, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.105 · Cited by 29 · see citing works
Self-citationKenney, J. W., Poole, R. L., Adoff, M. D., Logue, S. F., & Gould, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039939 · Cited by 30 · see citing works
Self-citationSex-specific behavioral effects of acute exposure to the neonicotinoid clothianidin in mice
Kubo, S., Hirano, T., Miyata, Y., Ohno, S., Onaru, K., Ikenaka, Y., Nakayama, S. M. M., Ishizuka, M., MANTANI, Y., YOKOYAMA, T., et al. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116283 · Cited by 28 · see citing works
Braida, D., Donzelli, A., Martucci, R., Ponzoni, L., Pauletti, A., Langus, A., & Sala, M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.12.040 · Cited by 26 · see citing works
Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits
Vieira‐Brock, P. L., McFadden, L. M., Nielsen, S. M., Smith, M. D., Hanson, G. R., & Fleckenstein, A. E. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv073 · Cited by 25 · see citing works
Gould, T. J., Wilkinson, D. S., Yildirim, E., Poole, R. L., Leach, P. T., & Simmons, S. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.009 · Cited by 24 · see citing works
Self-citationLeach, P. T., Cordero, K. A., & Gould, T. J. (2013) · Behavioral Neuroscience · doi:10.1037/a0031913 · Cited by 23 · see citing works
Self-citationGalvez, B., Gross, N. B., & Sumikawa, K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.008 · Cited by 23 · see citing works
Ponzoni, L., Braida, D., Carboni, L., Moretti, M., Viani, P., Clementi, F., Zoli, M., Gotti, C., & Sala, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104941 · Cited by 22 · see citing works
The efficiency of functional brain networks does not differ between smokers and non-smokers
Breckel, T. P. K., Thiel, C. M., & Gießing, C. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.07.005 · Cited by 20 · see citing works
Beretta, S., Gritti, L., Ponzoni, L., Scalmani, P., Mantegazza, M., Sala, M., Verpelli, C., & Sala, C. (2022) · Molecular Autism · doi:10.1186/s13229-021-00484-0 · Cited by 18 · see citing works
Duque, A., Vinader‐Caerols, C., & Monleón, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173182 · Cited by 19 · see citing works
Bekci, E., Gokmen, R. C., Kanıt, L., Gözen, O., Balkan, B., Koylu, E. O., & Keser, A. (2024) · Brain Sciences · doi:10.3390/brainsci14050427 · Cited by 18 · see citing works
Nicotine enhances the reconsolidation of novel object recognition memory in rats
Tian, S., Pan, S., & You, Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.019 · Cited by 16 · see citing works
Abulseoud, O. A., Ross, T. J., Nam, H. W., Caparelli, E. C., Tennekoon, M. S., Schleyer, B., Castillo, J., Fedota, J. R., Gu, H., Yang, Y., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0741-9 · Cited by 16 · see citing works
Simmons, S. J., & Gould, T. J. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12171 · Cited by 16 · see citing works
Self-citationParikh, V., Cole, R. D., Patel, P., Poole, R. L., & Gould, T. J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.01.003 · Cited by 15 · see citing works
Self-citationLongatti, A., Ponzoni, L., Moretto, E., Giansante, G., Lattuada, N., Colombo, M. N., Francolini, M., Sala, M., Murru, L., & Passafaro, M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02502-x · Cited by 14 · see citing works
Energy sensors in drug addiction: A potential therapeutic target
López-Gambero, A. J., de Fonseca, F. R., & Suárez, J. (2020) · Addiction Biology · doi:10.1111/adb.12936 · Cited by 14 · see citing works
Yildirim, E., Connor, D. A., & Gould, T. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000111 · Cited by 13 · see citing works
Self-citationBorkar, C. D., Sagarkar, S., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2017) · Addiction Biology · doi:10.1111/adb.12579 · Cited by 13 · see citing works
Poole, R. L., Connor, D. A., & Gould, T. J. (2014) · Behavioral Neuroscience · doi:10.1037/bne0000003 · Cited by 11 · see citing works
Self-citationLeach, P. T., Holliday, E. D., Kutlu, M. G., & Gould, T. J. (2014) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntu229 · Cited by 12 · see citing works
Self-citationRehman, N. U., Esmaeilpour, K., Joushi, S., Abbas, M., al‐Rashida, M., Rauf, K., & Masoumi‐Ardakani, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110783 · Cited by 10 · see citing works
Keady, J. V., Hessing, M. C., Songrady, J. C., McLaurin, K. A., & Turner, J. R. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00656-6 · Cited by 9 · see citing works
Systems genetic analysis of nicotine withdrawal deficits in hippocampus‐dependent learning
Goldberg, L. R., Kutlu, M. G., Zeid, D., Seemiller, L. R., & Gould, T. J. (2021) · Genes Brain & Behavior · doi:10.1111/gbb.12734 · Cited by 9 · see citing works
Self-citationKim, B., & Im, H. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00227-0 · Cited by 9 · see citing works
Connor, D. A., Kutlu, M. G., & Gould, T. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117695861 · Cited by 8 · see citing works
Self-citationMolas, S., Gener, T., Güell‐Bosch, J., Martı́n, M., Ballesteros‐Yáñez, I., Sanchez-Vives, M. V., & Dierssen, M. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0147-1 · Cited by 8 · see citing works
Kutlu, M. G., Braak, D. C., Tumolo, J. M., & Gould, T. J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.023 · Cited by 7 · see citing works
Self-citationHuang, B. Y., Chen, Z., Huang, F., Gao, F., Chen, J., Liu, P., Lu, Z., Chen, W., & Wu, J. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110901 · Cited by 7 · see citing works
Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice
Jia, S., Jing, X., Wang, R., Su, M., Wang, P., Feng, Y., Ren, X., Tu, L., Wei, P., Lu, Z. Z., et al. (2025) · Advanced Science · doi:10.1002/advs.202415311 · Cited by 6 · see citing works
Chronic nicotine impairs sparse motor learning via striatal fast‐spiking parvalbumin interneurons
Kim, B. S., & Im, H. (2020) · Addiction Biology · doi:10.1111/adb.12956 · Cited by 5 · see citing works
Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory
Leach, P. T., Kenney, J. W., Connor, D. A., & Gould, T. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.026 · Cited by 6 · see citing works
Self-citationThe Effects of Nicotine on Learning and Memory
Gould, T. J. (2014) · The Receptors · doi:10.1007/978-1-4939-1167-7_11 · Cited by 5 · see citing works
Self-citationGonçalves, P. F. R., Nunes, L. E. D., Andrade, B. D. S., da Silva, M. O. L., Souza, I. N. D. O., Assunção‐Miranda, I., Castro, N. G., & Neves, G. A. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110821 · Cited by 3 · see citing works
Yadegary, A., Nazari-Serenjeh, F., & Darbandi, N. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102025 · Cited by 3 · see citing works
Kutlu, M. G., Holliday, E. L., & Gould, T. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00004-1
Self-citationde Lima Vieira Brock, P. (2019) · J. Willard Marriott Library · doi:10.26053/0j-t9x7-v964
Emergent Cognitive Impairment During Early Nicotine Withdrawal ∗
Schuster, R. M., & Evins, A. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00015-6
Rodefer, J. S., & Maitland, S. C. (2022) · Developmental Psychobiology · doi:10.1002/dev.22343
Protracted neurobehavioral and microRNA deficits by acute nicotine dependence in mice
Kim, B., & Im, H. (2024) · Communications Biology · doi:10.1038/s42003-024-07207-0
Kim, B. S., & Im, H.-I. (2024) · Figshare · doi:10.6084/m9.figshare.24995471
Hippocampal ring finger protein 10-dependent signaling supports cognitive flexibility
Romito, E., Carrano, N., Ribeiro, A., Italia, M., Gómez-Blanco, J. I., Greca, F. L., Genova, F., D’Andrea, L., Zianni, E., Ponzoni, L., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117651
Li, X., Li, Y., Li, Y., Wang, W., Ma, S., Li, J., Cheng, X., Guang, C., Hong, E., Chen, H., et al. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1947643
- Authors
- Kenney, J. W., Adoff, M. D., Wilkinson, D. S., & Gould, T. J.
- Affiliations
- University of Southampton (GB)
- Temple University (US)
- Corresponding author
- Gould, Thomas J.
- Venue
- Psychopharmacology
- Published
- 2011-04-13
- Volume
- 217
- Issue
- 3
- Pages
- 353-365
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3161157
- OpenAlex
- W1980057836
- Cited by
- 67
- References
- 61
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 9 · 2012: 5
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (DA024787, DA 07237, R01DA024787, T32DA007237)
- National Cancer Institute (CA-143187, P50CA143187)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, acute nicotine administration, chronic nicotine administration, nicotine withdrawal, novel object recognition, incidental learning, cholinergic activity, C57BL/6J mice
- MeSH terms
- Animals, Chronic Disease, Conditioning, Classical, Disease Models, Animal, Exploratory Behavior, Fear, Learning, Male, Memory, Mice, Inbred C57BL, Nicotine, Pattern Recognition, Visual, Spatial Behavior, Time Factors, Infusion Pumps, Implantable, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
