The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map
Open accessAbstract
Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map .
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Cites
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Cited by
Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review
Hassan, M., Awan, F. M., Naz, A., deAndrés-Galiana, E. J., Alvarez, O., Cernea, A., Fernández-Brillet, L., Fernández-Martínez, J. L., & Kloczkowski, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094645 · Cited by 317
“MIMs explore the information about different mechanistic pathways and regulatory modules involved in a disease such as Parkinson’s [39] or signaling in cancer [40], respectively.”
BackgroundMaking sense of big data in health research: towards an EU action plan
Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., et al. (2016) · Genome Medicine · doi:10.1186/s13073-016-0323-y · Cited by 286
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Self-citationThe endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
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Garcia, P., Jürgens‐Wemheuer, W., Uriarte Huarte, O., Michelucci, A., Masuch, A., Brioschi, S., Weihofen, A., Koncina, E., Coowar, D., Heurtaux, T., et al. (2022) · Glia · doi:10.1002/glia.24149 · Cited by 65
Self-citationPost-COVID-19 Parkinsonism and Parkinson’s Disease Pathogenesis: The Exosomal Cargo Hypothesis
Mysiris, D. S., Vavougios, G. D., Karamichali, E., Papoutsopoulou, S., Stavrou, V. T., Papayianni, E., Boutlas, S., Mavridis, T., Foka, P., Zarogiannis, S. G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179739 · Cited by 25
Geerts, H., Hofmann‐Apitius, M., Anastasio, T. J., & Initiative, B. H. M. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.08.011 · Cited by 20
Metadata
- Authors
- Fujita, K. A., Ostaszewski, M., Matsuoka, Y., Ghosh, S., Glaab, E., Trefois, C., Crespo, I., Perumal, T. M., Jurkowski, W., Antony, P. M. A., Diederich, N., Buttini, M., Kodama, A., Satagopam, V. P., Eifes, S., del Sol, A., Schneider, R., Kitano, H., & Balling, R.
- Venue
- Molecular Neurobiology
- Published
- 2013-07-07
- Volume
- 49
- Issue
- 1
- Pages
- 88-102
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2023250031
- Cited by
- 273
- References
- 44
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
