CoChat
Sign Up
Cited by 137Nutrition, Genetics, and DiseasePhytochemicals and Antioxidant ActivitiesNeuroprotection in Cerebral Ischemia

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Virmani, Ashraf, Pinto, Luigi, Binienda, Zbigniew, Ali, Syed·2013·Molecular Neurobiology
DOI 10.1007/s12035-013-8498-3
Open this paper in CoChat — free account

Abstract

Diet in human health is no longer simple nutrition, but in light of recent research, especially nutrigenomics, it is linked via evolution and genetics to cell health status capable of modulating apoptosis, detoxification, and appropriate gene response. Nutritional deficiency and disease especially lack of vitamins and minerals is well known, but more recently, epidemiological studies suggest a role of fruits and vegetables, as well as essential fatty acids and even red wine (French paradox), in protection against disease. In the early 1990s, various research groups started considering the use of antioxidants (e.g., melatonin, resveratrol, green tea, lipoic acid) and metabolic compounds (e.g., nicotinamide, acetyl-L-carnitine, creatine, coenzyme Q10) as possible candidates in neuroprotection. They were of course considered on par with snake oil salesman (women) at the time. The positive actions of nutritional supplements, minerals, and plant extracts in disease prevention are now mainstream and commercial health claims being made are subject to regulation in most countries. Apart from efficacy and finding, the right dosages, the safety, and especially the level of purification and lack of contamination are all issues that are important as their use becomes widespread. From the mechanistic point of view, most of the time these substances replenish the body's deficiency and restore normal function. However, they also exert actions that are not sensu stricto nutritive and could be considered pharmacological especially that, at times, higher intake than recommended (RDA) is needed to see these effects. Free radicals and neuroinflammation processes underlie many neurodegenerative conditions, even Parkinson's disease and Alzheimer's disease. Curcumin, carotenoids, acetyl-L-carnitine, coenzyme Q10, vitamin D, and polyphenols and other nutraceuticals have the potential to target multiple pathways in these conditions. In summary, augmenting neuroprotective pathways using diet and finding new natural substances that can be more efficacious, i.e., induction of health-promoting genes and reduction of the expression of disease-promoting genes, could be incorporated into neuroprotective strategies of the future.

Overview

Integrity signals

Registry

Crossref · 10.1007/s12035-013-8498-3

Cites

84 of 84 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 82 references

Cited by

Sorted by citations

Items 101–137 of 137

Related

See all

Metadata

Authors
Virmani, A., Pinto, L., Binienda, Z., & Ali, S.
Affiliations
  • Sigma Tau (Italy) (IT)
  • National Center for Toxicological Research (US)
Corresponding author
Virmani, Ashraf
ORCID
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2013-06-28
Volume
48
Issue
2
Pages
353-362
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
DOI
10.1007/s12035-013-8498-3
OpenAlex
W2024679196
Cited by
137
References
82
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 16 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 17 · 2017: 14 · 2016: 14 · 2015: 16 · 2014: 21
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords
nutrigenomics, neuroprotection, neurodegeneration, diet, antioxidants, nutraceuticals, free radicals, neuroinflammation, Parkinson's disease, Alzheimer's disease, curcumin, carotenoids, acetyl-L-carnitine, coenzyme Q10, vitamin D, polyphenols, resveratrol, melatonin, alpha-lipoic acid, essential fatty acids, French paradox, red wine, dietary supplements, gene expression regulation
MeSH terms
Aging, Animals, Food, Humans, Nerve Degeneration, Neuroprotective Agents, Systems Biology, Nutrigenomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review