Picalm rs3851179 variant confers susceptibility to alzheimer’s disease in chinese population
Abstract
The association between PICALM rs3851179 variant and Alzheimer's disease (AD) has been well established by previous genome-wide association studies (GWAS) and candidate gene studies in European population. Recent studies investigated the association between PICALM rs3851179 and AD susceptibility in Chinese population. However, these studies reported consistent and inconsistent results. Here, we selected 9435 samples including 3704 AD cases and 5731 controls from previous studies and evaluated this association using a meta-analysis method for additive model. We did not observe significant genetic heterogeneity in Chinese population. Our results indicate significant association between PICALM rs3851179 and AD in Chinese population. The sensitivity analysis indicates that the association between rs3851179 and AD did not vary substantially. The regression analysis suggests no significant publication bias. In summary, this updated meta-analysis highlights the involvement of PICALM rs3851179 variant in Alzheimer's disease susceptibility in Chinese population.
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Gene coding is related to Alzheimer's disease.
“The gene coding is related to Alzheimer’s disease [37,38,39].”
From An Efficient Classifier for Alzheimer’s Disease Genes Identification (2018) · cites this paper as [39]
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- Authors
- Liu, G., Xu, Y., Jiang, Y., Zhang, L., Feng, R., & Jiang, Q.
- Affiliations
- Harbin Institute of Technology (CN)
- Harbin Medical University (CN)
- Rice University (US)
- Corresponding author
- Jiang, Qinghua
- Venue
- Molecular Neurobiology
- Published
- 2016-04-05
- Volume
- 54
- Issue
- 5
- Pages
- 3131-3136
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2334629405
- Cited by
- 57
- References
- 27
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 16 · 2017: 7 · 2016: 4
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Nature Science Foundation of China (81300945, 61571152)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- Alzheimer's disease, PICALM, genetic susceptibility, Chinese population, genetic association, genetic heterogeneity, publication bias
- MeSH terms
- Alzheimer Disease, Humans, Publication Bias, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Monomeric Clathrin Assembly Proteins, Asian People
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