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Cited by 62Peptidase Inhibition and AnalysisMedical Imaging Techniques and ApplicationsNeuroendocrine Tumor Research Advances

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Characterization of the benign lesions with increased 68Ga-FAPI-04 uptake in PET/CT

Zheng, Shan, Lin, Rong, Chen, Shaoming, Zheng, Jieling, Lin, Zefang, Zhang, Ying, Xue, Qianqian, Chen, Yun, Zhang, Jiaying, Lin, Kaixian, You, Xin, Yao, Shaobo, Miao, Weibing·2021·Annals of Nuclear Medicine
DOI 10.1007/s12149-021-01673-w
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Abstract

Objectives The objective of the study was to characterize benign lesions showing increased 68 Ga-FAPI-04 uptake on FAPI PET/CT. Methods We retrospectively reviewed 182 patients with suspected various cancers who were performed 68 Ga-FAPI-04 PET/CT imaging from August 2020 to December 2020. The diagnoses of the benign lesions were made by the CT findings (CT), other imaging information (OII) (contrast enhance CT, FDG PET, ultrasound, MRI or others), clinical information (CI) (medical history, laboratory examination, symptom, physical sign and follow-up information) or histological biopsy (HB). Results A total of 185 primary malignant tumors were detected by FAPI PET/CT with the median SUV max of 9.0 (range from 0.97 to 25.71). There were 360 benign lesions with increased FAPI uptake were detected in 146 (146/182, 80.2%) patients with the median SUV max of 3.64 (range from 1.39 to 21.56), including inflammatory processes (n = 231, 64.2%), exostosis (n = 54, 15%), hemorrhoid (n = 47, 13.1%), fracture (n = 17, 4.7%), hepatic fibrosis (n = 4, 1.1%), and others (n = 7, 1.9%). Conclusion Benign lesions with increased 68 Ga-FAPI-04 uptake are common. The overall SUV max of benign lesions is lower than that of malignant tumors, however there is a large overlap of SUV max range. Similar to FDG PET, some benign lesions can be easily diagnosed by combining CT findings, special location and clinical data, but there are still some lesions that may be confused with malignant lesions, which…

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Crossref · 10.1007/s12149-021-01673-w

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  • Sources of false positive or negative findings still remain with higher-specificity tracers and must be considered during image interpretation.

    “However, sources of false positive or negative findings still remain with these tracers [131,132,133,134] and must be considered during image interpretation.”

    From Influences on PET Quantification and Interpretation (2022) · cites this paper as [134]

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Metadata

Authors
Zheng, S., Lin, R., Chen, S., Zheng, J., Lin, Z., Zhang, Y., Xue, Q., Chen, Y., Zhang, J., Lin, K., You, X., Yao, S., & Miao, W.
Affiliations
  • First Affiliated Hospital of Fujian Medical University (CN)
  • Fujian Medical University (CN)
Corresponding author
  • Yao, Shaobo
  • Miao, Weibing
ORCID
Venue
Annals of Nuclear Medicine
Publisher
Springer Science and Business Media LLC
Published
2021-08-23
Volume
35
Issue
12
Pages
1312-1320
ISSN
  • 0914-7187 (ISSN-L)
  • 1864-6433
DOI
10.1007/s12149-021-01673-w
OpenAlex
W3195971584
Cited by
62
References
39
Citations by year
2026: 8 · 2025: 13 · 2024: 12 · 2023: 15 · 2022: 13 · 2021: 1
FWCI
3.73
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Annals of Nuclear Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • national natural science foundation of china (81971651)
  • Natural Science Foundation of Fujian Province (2019J01454, 2020J05249)
  • Fujian Provincial Health Commission Science and Technology and Programme (2020GGA045)
  • Fujian Provincial Health and Family Planning Youth Scientific Research Project (2018-2-21)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Peptidase Inhibition and Analysis
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
  • Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
Keywords
68Ga-FAPI-04, FAPI PET/CT, benign lesions, false-positive uptake, inflammatory lesions, exostosis, hemorrhoids, fracture, liver fibrosis, SUVmax, differential diagnosis, FAPI-04
MeSH terms
Positron Emission Tomography Computed Tomography, Adult, Aged, Aged, 80 and over, Biological Transport, Female, Humans, Male, Middle Aged, Neoplasms, Quinolines, Retrospective Studies, Young Adult

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